Published: Jan. 1, 2023
The research aimed to create a groundbreaking neuromodulation method improve consciousness. Firstly, an innovative rhythmic sound and electric stimulation technique was introduced modulate consciousness in healthy individuals. Subsequently, this tested on patients with disorders. study concluded by examining the impact of brain connectivity, shedding light fundamental mechanism technique.
Language: Английский
مجلة الدراسات النفسیة المعاصرة جامعة بنى سویف, Journal Year: 2024, Volume and Issue: 6(1), P. 38 - 84
Published: March 1, 2024
ملخص البحث:سعي البحث الراهن إلى التعرف علي مدي قدرة المرونة الوظيفية بشقيها المعرفي والنفسي التنبؤ ببعض اضطرابات ما بعد السكتات الدماغية؛ ومنها اضطراب النوم واضطراب الوعي وكذلك الاكتئاب لدي بعض الناجين من الدماغية، اعتبار أن تلك الاضطرابات أحد موضوعات علم النفس العصبي الإكلينيكي، بالإضافة إلي الفروق في متغيرات ضوء كل متغير النوع ومتغير التجنيب الشقي للاحتشاء. تكونت عينة عدد (50) مشاركًا المرضي الدماغية. تراوحت أعمارهم بين (19.25: 56)( 43.14 8.92) سنة. كما وُزعت العينة وفقا لمتغير للاحتشاء، خلال فحص الرنين المغناطيسي، احتشاء شقي أيمن (32%) وأيسر(36%) وثنائي بكلا الشقين(32%)، شكل الذكور(68%) الكلية. أدوات البحث؛ مقياس النفسية، واختبار الويسكونسن لتصنيف البطاقات، ومؤشر جودة لبيتسبرج، واستبيان صحة المريض، وفحص الحالة العقلية العامة المُصغر.وخًلُص نتائج مفادها؛ تنبأت النفسي والمعرفي باضطراب النوم، النفسية أيضًا، حيث ارتبطت سلبيا باضطرابي والنوم معاً، حين المعرفية الوعي، ارتباطها السلبي معًا. وفيما يخص العلاقات السكتة فنجد قد ارتبط إيجابيًا وسلبيًا وارتبط الأخير سلبيًا النوم. لم تكن هناك فروق دالة إحصائيًا وكانت اتجاه مجموعة الناجيات الإناث.
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Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: July 2, 2024
Background Disorders of consciousness (DoC) represent a spectrum neurological conditions that pose significant treatment challenges. Percutaneous short-term spinal cord stimulation (SCS) has emerged as promising experimental diagnostic to assess and potentially improve levels. However, the effectiveness this intervention is frequently compromised by shift electrodes, particularly in cervical region, which can negatively affect therapeutic outcomes. Methods This retrospective study aimed if electrodes percutaneous SCS patients with DoC would outcome. We analyzed relationship between electrode length patient outcome, well correlation various anatomical parameters, including actual spine, linear length, canal transverse diameter, C2 cone height, cohort undergoing procedure. Results Our findings revealed better there are less ( p = 0.019). Further, was found patients’ outcome (Rho 0.583, 0.002), longer lengths associated poorer Contrary our expectations, no association measured parameters extent shift. trend spine 0.098). Notably, shorter diameter be significantly receiving 0.033). Conclusion These results highlight clinical importance stability region during for DoC. Ensuring secure placement may play crucial role enhancing minimize postoperative complications. Given lack expected future research should investigate other factors could impact optimize intervention.
Language: Английский
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medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 18, 2024
ABSTRACT Disorders of consciousness (DoC) are states impaired arousal or awareness. Deep brain stimulation (DBS) is a potential treatment, but outcomes vary, possibly due to differences in patient characteristics, electrode placement, specific networks. We studied 40 patients with DoC who underwent DBS targeting the thalamic centromedian-parafascicular complex. Better-preserved gray matter, especially striatum, correlated improvement. Stimulation was most effective when electric fields extended into parafascicular and subparafascicular nuclei—ventral centromedian nucleus, near midbrain— it engaged projection pathways ascending network, including hypothalamus, brainstem, frontal lobe. Moreover, sites were connected networks similar those underlying generalized absence seizures acquired lesions. These findings support therapeutic for DoC, emphasizing importance precise revealing broader link between treatment mechanisms other conscciousness-impairing conditions.
Language: Английский
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bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 8, 2024
Abstract Disorders of consciousness (DoC) encompass a range states characterized by prolonged altered awareness due to heterogeneous brain damage and are associated with highly diverse prognoses. However, the neural mechanisms underlying such recoveries in DoC remain unclear. To address this issue, we analysed neuronal spiking activities recorded from central thalamus (CT), key hub arousal regulation, cohort 23 patients receiving deep stimulation treatment. Using machine learning techniques, identified core set electrophysiological features CT, particularly theta rhythm, that could account for individual recovery outcomes across varied etiologies (trauma, brainstem hemorrhage, anoxia), clinical baselines patient ages. These also correctly one subgroup who exhibited poor initial manifestations but recovered unexpectedly. Simulating conductance-based model further revealed neurodynamics rhythm CT during different stages recovery. Taken together, these findings uncover previously unknown, unified mechanism governs DoC.
Language: Английский
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Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: Dec. 18, 2024
Abstract Among the existing research on treatment of disorders consciousness (DOC), deep brain stimulation (DBS) offers a highly promising therapeutic approach. This comprehensive review documents historical development DBS and its role in DOC, tracing progression from an experimental therapy to detailed modulation approach based mesocircuit model hypothesis. The hypothesis suggests that DOC arises disruptions critical network regions, providing framework for refining targets. We also discuss multimodal approaches assessing patients with encompassing clinical behavioral scales, electrophysiological assessment, neuroimaging techniques methods. During evolution therapy, segmentation central nuclei, recording single-neurons, analysis local field potentials have emerged as favorable technical factors enhance efficacy treatment. Advances computational models facilitated deeper exploration neural dynamics associated linking neuron-level macroscopic changes. Despite showing outcomes, challenges remain patient selection, precise target localization, determination optimal parameters. Future should focus conducting large-scale controlled studies delve into pathophysiological mechanisms DOC. It is imperative further elucidate modulatory effects thalamo-cortical cortico-cortical functional connectivity networks. Ultimately, by optimizing neuromodulation strategies, we aim substantially outcomes greatly expedite process recovery patients.
Language: Английский
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Neuromodulation Technology at the Neural Interface, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
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MedComm, Journal Year: 2024, Volume and Issue: 5(12)
Published: Dec. 1, 2024
Abstract Cerebral vascular malformations (CVMs), particularly cerebral cavernous and arteriovenous malformations, pose significant neurological challenges due to their complex etiologies clinical implications. Traditionally viewed as congenital conditions with structural abnormalities, CVMs have been treated primarily through resection, embolization, stereotactic radiosurgery. While these approaches offer some efficacy, they often risks integrity invasive nature. Advances in next‐generation sequencing, high‐depth whole‐exome sequencing bioinformatics, facilitated the identification of gene variants from neurosurgically resected samples. These advancements deepened our understanding CVM pathogenesis. Somatic mutations key mechanistic pathways identified causative factors, leading a paradigm shift treatment. Additionally, recent progress noninvasive minimally techniques, including imaging genomics, liquid biopsy, or endovascular biopsies (endovascular sampling blood vessel lumens), has enabled associated CVMs. methods, conjunction data, potential for early detection, dynamic monitoring, targeted therapies that could be used monotherapy adjuncts surgery. This review highlights pathogenesis precision therapies, outlining future medicine management.
Language: Английский
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Published: Jan. 1, 2023
The research aimed to create a groundbreaking neuromodulation method improve consciousness. Firstly, an innovative rhythmic sound and electric stimulation technique was introduced modulate consciousness in healthy individuals. Subsequently, this tested on patients with disorders. study concluded by examining the impact of brain connectivity, shedding light fundamental mechanism technique.
Language: Английский
Citations
0