Nicotine Dosimetry in Evaluating Electronic Cigarettes Compared to Cigarette Smoking: Implications for Tobacco Regulatory Science DOI Creative Commons

N L Benowitz,

Hongbo Yang, Peyton Jacob

et al.

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

The delivery and systemic absorption of nicotine are important for assessing the potential safety efficacy novel inhaled devices. We describe an experimental approach examining intake, looking at individual variability, comparing JUUL electronic cigarettes cigarette smoking, standardized puffing ad libitum use. Fourteen smokers who were infrequent e-cigarette users vaped or smoked cigarettes, both in a session (ten 3.5 s puffs over 5 min) 4 h use session. Plasma concentrations measured, using sex body weight-based population clearance predictions, dose was estimated each pharmacokinetically (PK)-estimated averaged 0.55 mg (range 0.16–0.82) 1.15 0.35–4.56) smoking. PK-estimated with 4.1 0.4–9.5) 5.0 1.5–15) smoking (average 3.4 cigarettes). Within correlations, vs weak (r = 0.45, NS) but much stronger 0.82, p < 0.001). Data from predicted that consumption liquid contained pod would correspond to 15 which is similar observed real world studies. conclude vaping sessions do not predict usual self-administration behavior With use, intake more provides better predictor product world. This recommended screening devices aid FDA regulatory decision making.

Language: Английский

Nicotine Dosimetry in Evaluating Electronic Cigarettes Compared to Cigarette Smoking: Implications for Tobacco Regulatory Science DOI Creative Commons

N L Benowitz,

Hongbo Yang, Peyton Jacob

et al.

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

The delivery and systemic absorption of nicotine are important for assessing the potential safety efficacy novel inhaled devices. We describe an experimental approach examining intake, looking at individual variability, comparing JUUL electronic cigarettes cigarette smoking, standardized puffing ad libitum use. Fourteen smokers who were infrequent e-cigarette users vaped or smoked cigarettes, both in a session (ten 3.5 s puffs over 5 min) 4 h use session. Plasma concentrations measured, using sex body weight-based population clearance predictions, dose was estimated each pharmacokinetically (PK)-estimated averaged 0.55 mg (range 0.16–0.82) 1.15 0.35–4.56) smoking. PK-estimated with 4.1 0.4–9.5) 5.0 1.5–15) smoking (average 3.4 cigarettes). Within correlations, vs weak (r = 0.45, NS) but much stronger 0.82, p < 0.001). Data from predicted that consumption liquid contained pod would correspond to 15 which is similar observed real world studies. conclude vaping sessions do not predict usual self-administration behavior With use, intake more provides better predictor product world. This recommended screening devices aid FDA regulatory decision making.

Language: Английский

Citations

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