Traditional Chinese Medicine-based Treatment in Cardiovascular Disease: Potential Mechanisms of Action

Current Pharmaceutical Biotechnology, Journal Year: 2024, Volume and Issue: 25(17), P. 2186 - 2199

Published: Feb. 13, 2024

Cardiovascular Disease (CVD) is the leading cause of morbidity and death worldwide has become a global public health problem. Traditional Chinese medicine (TCM) been used in China to treat CVD achieved promising results. Therefore, TCM aroused significant interest among pharmacologists medical practitioners. Previous research showed that can regulate occurrence development atherosclerosis (AS), ischemic heart disease, failure, myocardial injury, fibrosis by inhibiting vascular endothelial inflammation, oxidant stress, ischemia-reperfusion remodeling. It well-known characteristics multi-component, multi-pathway, multitarget. Here, we systematically review bioactive components, pharmacological effects, clinical application preventing treating CVD.

Language: Английский

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Norisoboldine Alleviates Isoproterenol‐Induced Myocardial Ischemic Injury via the TLR4–MyD88‐Dependent NF‐κB Activation Pathway and Modulation of L‐Type Calcium Channels

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2025, Volume and Issue: 52(4)

Published: Feb. 26, 2025

Norisoboldine (NIB) displays beneficial effects on cardiovascular diseases, although its protective role and underlying mechanisms in myocardial ischemia (MI) injury remain elusive. The aim of this study is to explore the potential cardioprotective mechanism NIB MI caused by isoproterenol (ISO). We administered SD rats at 20 40 mg/kg daily for 7 days study; was followed an ISO injection induce injury. Parameters such as electrocardiogram readings, heart rate, serum concentrations creatine kinase (CK) kinase-MB (CK-MB), levels inflammatory markers, some histopathological assessments oxidative stress markers were evaluated. conducted Western blot analyses evaluate protein expression related apoptosis TLR4-MyD88-mediated NF-κB activation pathway. L-type Ca2+ current (ICa-L) contraction isolated ventricular cells from identified using patch-clamp methods IonOptix detection system. treatment with resulted improvements rate ST-segment changes, a reduction CK CK-MB levels, restoration superoxide dismutase, catalase glutathione decrease malondialdehyde accumulation. Furthermore, reduced lowered reactive oxygen species production improved tissue morphology. It also countered ISO-induced alterations TLR4-MyD88-dependent Additionally, considerably attenuated ICa-L contractile function cardiomyocytes. These results suggest that effectively mitigates through anti-inflammatory, antioxidative, anti-apoptotic mechanisms, potentially involving pathway calcium balance.

Language: Английский

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Electroacupuncture Preconditioning Attenuates Myocardial Ischemia-Reperfusion Injury in Rats Partially Through Nrf2-Mediated Reduction of Oxidative Stress and Pyroptosis

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 20, 2025

Oxidative stress and pyroptosis have been established as key contributors to myocardial ischemia-reperfusion injury (MIRI). While previous studies reported that electroacupuncture (EA) preconditioning exerted cardioprotective effects, the underlying mechanisms remain elusive. Thus, this study aimed investigate effects of EA on oxidative in MIRI rats, explore role nuclear factor E2-associated 2 (Nrf2) throughout process. A model was constructed by ligating left anterior descending coronary artery for 30 min, followed 4 h reperfusion rats. Prior modeling, rats were subjected at Neiguan Point three days. Furthermore, ML385, a Nrf2 inhibitor, administered order examine regulating following preconditioning. The results revealed improved ventricular function after reduced both infarction area cTnT levels. Meanwhile, alleviated MIRI-induced pyroptosis, evidenced downregulation ROS, MDA, NF-[Formula: see text]B p65, caspase-1, IL-1[Formula: text], GSDMD-N, upregulation SOD HO-1. Mechanistically, up-regulated enhanced expression Nrf2. However, its ability attenuate suppressed inhibition Taken together, our indicated attenuated mitigating with playing vital protective mechanism.

Language: Английский

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Crosstalk among Reactive Oxygen Species, Autophagy and Metabolism in Myocardial Ischemia and Reperfusion Stages

Aging and Disease, Journal Year: 2023, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2023

Myocardial ischemia is the most common cardiovascular disease. Reperfusion, an important myocardial tool, causes unexpected and irreversible damage to cardiomyocytes, resulting in ischemia/reperfusion (MI/R) injury. Upon stress, especially oxidative stress induced by reactive oxygen species (ROS), autophagy, which degrades intracellular energy storage produce metabolites that are recycled into metabolic pathways buffer initiated during MI/R Excellent cardioprotective effects of autophagy regulators against MI have been reported. Reversing disordered cardiac metabolism ROS also exhibits action patients with ischemia. Herein, we review current knowledge on crosstalk between ROS, MI/R. Finally, discuss possible can be exploited harness therapeutic potential diagnosis treatment

Language: Английский

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Potential Targets of Natural Products for Improving Cardiac Ischemic Injury: The Role of Nrf2 Signaling Transduction

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2005 - 2005

Published: April 26, 2024

Myocardial ischemia is the leading cause of health loss from cardiovascular disease worldwide. and hypoxia during exercise trigger risk sudden death which, in severe cases, will further lead to myocardial infarction. The Nrf2 transcription factor an important antioxidant regulator that extensively engaged biological processes such as oxidative stress, inflammatory response, apoptosis, mitochondrial malfunction. It has a significant role prevention treatment several illnesses, since it can control not only expression genes, but also target genes associated pathological processes. Therefore, targeting have great potential ischemic injury. Natural products are widely used treat diseases because their few side effects. A large number studies shown be way for natural alleviate ischemia. However, specific related mechanism mediating still unclear. this review combs key possible injury, emphatically summarizes treating symptoms, thus providing broad foundation clinical transformation.

Language: Английский

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Low-intensity pulsed ultrasound of different intensities differently affects myocardial ischemia/reperfusion injury by modulating cardiac oxidative stress and inflammatory reaction

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 7, 2023

Introduction The prevalence of ischemic heart disease has reached pandemic levels worldwide. Early revascularization is currently the most effective therapy for diseases but paradoxically induces myocardial ischemia/reperfusion (MI/R) injury. Cardiac inflammatory reaction and oxidative stress are primarily involved in pathology MI/R Low-intensity pulsed ultrasound (LIPUS) been demonstrated to reduce cell injury by protecting against many diseases, including cardiovascular rarely on Methods This study was designed clarify whether LIPUS alleviates alleviating stress. Simultaneously, we have also tried confirm which intensity might be more suitable ameliorate injury, as well signaling mechanisms. simulated (SI/R) were respectively induced Sprague Dawley rats human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs). treatment, biochemical measurements, death assay, estimation cardiac reaction, protein detections western blotting performed according protocol. Results In our study, both vivo vitro, 0.1 W/cm 2 (LIPUS ) 0.5 make no significant difference under normoxic condition. Under hypoxic condition, partially ameliorated significantly aggravated 2.5 vitro. activation apoptosis signal-regulating kinase 1 (ASK1)/c-Jun N-terminal (JNK) pathway with partly rectified Conclusion Our firstly that different intensities differently affects regulating Modulations ASK1/JNK mechanism exerts cardioprotective effects. promising clinical translation will great welfare patients suffering from

Language: Английский

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The Impact of Acute Low-Dose Gamma Irradiation on Biomass Accumulation and Secondary Metabolites Production in Cotinus coggygria Scop. and Fragaria × ananassa Duch. Red Callus Cultures

Metabolites, Journal Year: 2023, Volume and Issue: 13(8), P. 894 - 894

Published: July 28, 2023

Cotinus coggygria Scop. (smoketree) and Fragaria × ananassa Duch. (strawberry) are two industrially important species due to their composition in bioactive compounds. In this study, we investigated the effects of acute low-dose gamma irradiation (15, 20, 25, 30, 35 40 Gy) on red callus cultures established smoketree strawberry. The biomass production, dry weight, content phenols, flavonoids, monomeric anthocyanins’, index anthocyanins polymerization antioxidant activity were evaluated. For callus, a negative correlation between doses accumulation was observed. strawberry did not significantly affect biomass. An increased weight observed irradiated while for treated decrease recorded. Irradiation with 30 Gy stimulative polyphenols’ both cultures; however, increase significant only callus. flavonoids variants, it decreased Gy. except 25 variant (1.65 ± 0.4 mg C-3-GE/g DW), all treatments caused an anthocyanins’ accumulation. smoketree, 15 (2.14 0.66 determined synthesis, highest value being seen 20 (2.8 0.94 DW). According UPLC-HRMS investigations, unidentified compound by 99% at dose maslinic acid 51% after results study showed, first time, differential response performant irradiation, biotechnological method that can be used stimulate synthesis triterpenes.

Language: Английский

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Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 18, 2024

Prostate cancer has the second highest incidence among male malignancies. Only a few studies exist on inhibitory effects of maslinic acid (MA) prostate cancer. Herein we found that MA inhibits cell proliferation by decreasing CDK2, CDK4, and CDK6 expression concurrently increasing p27, Rb, p-Rb expression. Further, was observed to induce autophagy p53, p-p53, ULK1, Beclin1, Atg7, Atg5 ratio LC3-II/I ERK1/2 mTOR. In addition, induced RM-1 ferroptosis regulating glutathione, glutamate, oxidized glutathione concentrations, inhibiting SLC7A11 activity, downregulating GPX4 Integrated metabolome transcriptome analysis led identification key pathways (e.g., in metabolism). Real-time quantitative PCR confirmed regulates ABCA1 , JUN NFKBIA . vivo demonstrated 50 mg/kg significantly inhibited growth tumors established using cells. To summarize, report both vitro inducing via transcriptomic metabolomic reprogramming.

Language: Английский

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