Nonlinear mechanisms for enhanced and synchronized post-inhibitory rebound spiking associated with seizures in an inhibitory–excitatory neuronal network DOI
Yanbing Jia, Huaguang Gu, Xianjun Wang

et al.

Chaos An Interdisciplinary Journal of Nonlinear Science, Journal Year: 2025, Volume and Issue: 35(3)

Published: March 1, 2025

Recent experimental observations on seizures showed that the optogenetic activation of inhibitory interneurons cannot suppress but enhance frequency and synchronization spiking excitatory pyramidal neurons, i.e., synchronized post-inhibitory rebound (PIR) spiking. This complex phenomenon presents paradoxical functions novel etiologies seizures. In present study, nonlinear mechanisms conditions PIR are obtained in a network model neurons. Pyramidal neurons with low near bifurcation, characterized by small conductances (gh) hyperpolarization-activated cation (Ih) current applied current, easy to generate Strong stimulation activating high synapses large contribute Moreover, after stimulation, synaptic from can induce reduce Reducing membrane potential range for The be interpreted interactions between hyperpolarization Ih modulated gh stimulation. Furthermore, higher degrees appear lower frequency. During become silence difference potential, which remains within long intervals spikes results strong helpful recognizing modulating

Language: Английский

Nonlinear mechanisms for enhanced and synchronized post-inhibitory rebound spiking associated with seizures in an inhibitory–excitatory neuronal network DOI
Yanbing Jia, Huaguang Gu, Xianjun Wang

et al.

Chaos An Interdisciplinary Journal of Nonlinear Science, Journal Year: 2025, Volume and Issue: 35(3)

Published: March 1, 2025

Recent experimental observations on seizures showed that the optogenetic activation of inhibitory interneurons cannot suppress but enhance frequency and synchronization spiking excitatory pyramidal neurons, i.e., synchronized post-inhibitory rebound (PIR) spiking. This complex phenomenon presents paradoxical functions novel etiologies seizures. In present study, nonlinear mechanisms conditions PIR are obtained in a network model neurons. Pyramidal neurons with low near bifurcation, characterized by small conductances (gh) hyperpolarization-activated cation (Ih) current applied current, easy to generate Strong stimulation activating high synapses large contribute Moreover, after stimulation, synaptic from can induce reduce Reducing membrane potential range for The be interpreted interactions between hyperpolarization Ih modulated gh stimulation. Furthermore, higher degrees appear lower frequency. During become silence difference potential, which remains within long intervals spikes results strong helpful recognizing modulating

Language: Английский

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