Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 68 - 68

Published: Jan. 6, 2025

Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to simple methods, high efficiency, suitability large-scale industrial production. This innovative approach presents new opportunities enhance both safety therapeutic efficacy cancer treatments. review comprehensively explores recent progress in application PDANSs therapy. It begins detailing self-assembly mechanisms fundamental principles underlying PDANS formation. The discussion then advances strategies assembling single nanoparticles, well co-assembly multiple drugs. Subsequently, addresses combination treatment modalities, encompassing diagnostic applications. These include combinations chemotherapeutic agents, phototherapeutic approaches, integration chemotherapy with phototherapy, synergistic use immunotherapy other methods. Finally, highlights advancing tumor therapy prospects application, providing key insights future aimed at optimizing technology broadening its utility treatment.

Language: Английский

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Recent Advances in Photodynamic Therapy: Metal-Based Nanoparticles as Tools to Improve Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 932 - 932

Published: July 12, 2024

Cancer remains a significant global health challenge, with traditional therapies like surgery, chemotherapy, and radiation often accompanied by systemic toxicity damage to healthy tissues. Despite progress in treatment, these approaches have limitations such as non-specific targeting, toxicity, resistance development cancer cells. In recent years, nanotechnology has emerged revolutionary frontier therapy, offering potential solutions challenges. Nanoparticles, due their unique physical chemical properties, can carry therapeutic payloads, navigate biological barriers, selectively target Metal-based nanoparticles, particular, offer properties suitable for various applications. Recent advancements focused on the integration of metal-based nanoparticles enhance efficacy precision photodynamic therapy. Integrating into therapy represents paradigm shift, enabling strategies enhanced specificity reduced off-target effects. This review aims provide comprehensive understanding pivotal role We explore mechanisms, biocompatibility, applications highlighting challenges use, well combining nanoparticles/photodynamic other synergistic approach treatment.

Language: Английский

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Dual-modal imaging-guided agent based on NIR-II aggregation-induced emission luminogens with balanced phototheranostic performance

Chemical Science, Journal Year: 2024, Volume and Issue: 15(28), P. 10969 - 10979

Published: Jan. 1, 2024

We have developed a series of novel single AIE fluorophores based on the N , -diaryl dihydrophenazine moiety, which possess anti-quenching properties and can be utilized for efficient in vivo bioimaging cancer phototherapy.

Language: Английский

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Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: Dec. 8, 2023

Abstract The dysfunction of microglia in the development diabetes is associated with various diabetic complications, while traditional insulin therapy insufficient to rapidly restore function microglia. Therefore, search for new alternative methods treating diabetes-related urgently needed. Here, we evaluate effects transcranial photobiomodulation (tPBM) on microglial mice and investigate its mechanism. We find tPBM treatment effectively improves morphology reactivity. also show that stimulates brain drainage system through activation meningeal lymphatics, which contributes removal inflammatory factor, increase purinergic receptor P2RY12. Besides, energy expenditure locomotor activity are improved by tPBM. Our results demonstrate can be an efficient, non-invasive method caused diabetes, has potential prevent physiological disorders.

Language: Английский

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Immunological features of various molecular subtypes of cervical cancer and their prognostic implications in the context of disulfidptosis

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 14, 2025

Objective Cervical cancer ranks among the most prevalent malignancies impacting women globally. Disulfidptosis represents a recently identified pathway of cellular demise, although its role in context cervical is not well elucidated. This research investigates significance Disulfidptosis-Related Genes (DRGs) within cancer. Furthermore, it aims to analyze differences prognosis and immune infiltration different molecular subtypes. Methods We compiled genes associated with disulfidptosis from variety databases perform differential expression analysis. Subsequently, samples are grouped through consensus clustering. To evaluate cell infiltration, we employed CIBERSORT. Additionally, checkpoint (ICGs) were gathered existing literature databases, enabling statistical analyses two subtype (CESC). Following our using GO, KEGG, GSEA compare between Lastly, prognostic risk model was constructed LASSO regression validated ROC. Results study seven key genes: PCBP3, ARNT, ANP32E, DSTN, CD2AP, EPAS1 , ACTN1 .The clustering analysis showed DFS(disease-free survival) various clusters. The gene CXCL1 displayed highly significant A (Cluster 1) B 2) (CESC) samples. set enrichment negative regulation peptidase activity IL-17 signaling pathway, which link subtype-specific differentially expressed (DEGs). Conclusion Statistical subtypes CESC highlighted importance therapeutic targets. seeks enhance accuracy predictions, thereby establishing foundation for formulation personalized treatment approaches.

Language: Английский

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Single-cell transcriptomics reveals that tumor-infiltrating natural killer cells are activated by localized ablative immunotherapy and share anti-tumor signatures induced by immune checkpoint inhibitors

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 3, 2023

Abstract Rationale Natural killer (NK) cells provide protective anti-cancer immunity. However, the cancer therapy induced activation gene signatures and pathways in NK remain unclear. Methods We applied a novel localized ablative immunotherapy (LAIT) by synergizing photothermal (PTT) with intra-tumor delivering of immunostimulant N-dihydrogalactochitosan (GC), to treat breast using mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) mouse model. performed single-cell RNA sequencing (scRNAseq) analysis unveil cellular heterogeneity compare transcriptional alterations PTT, GC, LAIT within microenvironment (TME). Results ScRNAseq showed that subtypes, including cycling, activated, interferon-stimulated, cytotoxic cells. Trajectory revealed route toward cytotoxicity following pseudotime progression. Both GC elevated expression associated cell activation, cytolytic effectors, activating receptors, IFN pathway components, cytokines/chemokines subtypes. Single-cell transcriptomics immune checkpoint inhibitor (ICI)-treated animal human samples ICI-induced across several types. Furthermore, were also treatment. discovered types patients had significantly longer overall survival when they higher genes specifically upregulated LAIT. Conclusion Our findings show for first time activates positively correlate beneficial clinical outcomes patients. More importantly, our results further establish correlation between effects ICI on cells, hence expanding understanding mechanism remodeling TME shedding light potentials anti-tumor functions applications.

Language: Английский

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Wearable photobiomodulation halts thyroid cancer growth by leveraging thyroid photosensitivity

Bioengineering & Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

With papillary thyroid carcinoma (PTC) rates rising significantly, concerns about conventional treatments like thyroidectomy and radiotherapy highlight the need for non-invasive options. Our study explores photobiomodulation therapy (PBMT), which uses specific light wavelengths to evoke cellular responses in PTC treatment. research utilized a custom-designed optical system investigate PBMT, finding that blue at wavelength of 465 nm can safely effectively inhibit proliferation TPC-1 cell line by inducing cycle arrest. Additionally, we developed wirelessly powered wearable PBMT device, is equipped with an advanced delivery ensures precise consistent dosage. This device designed optimal patient comfort, suppressed tumor growth mouse models without adverse effects. indicates tissue's responsiveness as non-visual organ. study's innovative approach integrates disciplines oncology, biophysics, medical technology, thereby advancing treatment paradigms PTC. interdisciplinary bridge not only highlights our groundbreaking findings but also paves way future cancer photomedicine.

Language: Английский

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