Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 9, 2025
Pulmonary
hypertension
(PH)
is
still
an
aggressive
and
progressive
illness
with
vascular
remodeling
right
heart
failure
despite
the
therapeutic
advances
made
in
recent
past.
Biomaterials
offer
attractive
route
to
break
current
paradigms
by
inducing
repair,
facilitating
drug
targeting,
allowing
dynamic
regeneration
of
tissue.
This
review
taking
integrated
approach
investigates
revolutionary
role
played
novel
biomaterials
bio–nano
interfaces
PH
treatment.
We
classify
evaluate
several
classes
biomaterial
platforms
including
natural
polymers,
scaffolds
based
on
synthetic
extracellular
vesicles
(EVs),
stimulus-responsive
systems
emphasis
both
underlying
mechanisms
clinical
relevance.
further
address
progress
artificial
intelligence
(AI)-based
integrating
multi-omics
tools
provide
patient-tailored
therapy.
finally
touch
ongoing
limitations
enumerate
future
directions
required
take
forward
biomaterial-based
therapies
towards
reality.
Human Genomics,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Jan. 31, 2025
Non-communicable
diseases
(NCDs)
such
as
cardiovascular
diseases,
chronic
respiratory
cancers,
diabetes,
and
mental
health
disorders
pose
a
significant
global
challenge,
accounting
for
the
majority
of
fatalities
disability-adjusted
life
years
worldwide.
These
arise
from
complex
interactions
between
genetic,
behavioral,
environmental
factors,
necessitating
thorough
understanding
these
dynamics
to
identify
effective
diagnostic
strategies
interventions.
Although
recent
advances
in
multi-omics
technologies
have
greatly
enhanced
our
ability
explore
interactions,
several
challenges
remain.
include
inherent
complexity
heterogeneity
multi-omic
datasets,
limitations
analytical
approaches,
severe
underrepresentation
non-European
genetic
ancestries
most
omics
which
restricts
generalizability
findings
exacerbates
disparities.
This
scoping
review
evaluates
landscape
data
related
NCDs
2000
2024,
focusing
on
advancements
integration,
translational
applications,
equity
considerations.
We
highlight
need
standardized
protocols,
harmonized
data-sharing
policies,
advanced
approaches
artificial
intelligence/machine
learning
integrate
study
gene-environment
interactions.
also
opportunities
translating
insights
(GxE)
research
into
precision
medicine
strategies.
underscore
potential
advancing
enhancing
patient
outcomes
across
diverse
underserved
populations,
emphasizing
fairness-centered
strategic
investments
build
local
capacities
underrepresented
populations
regions.
npj Vaccines,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 30, 2024
The
absence
of
validated
correlates
protection
(CoPs)
hampers
the
rational
design
and
clinical
development
new
tuberculosis
vaccines.
In
this
review,
we
provide
an
overview
potential
CoPs
in
vaccine
research.
Major
hindrances
opportunities
are
then
discussed.
Based
on
recent
progress,
it
is
reasonable
to
anticipate
that
success
ongoing
efforts
identify
would
be
a
game-changer
development.
Journal of Chemical Information and Modeling,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Rare
diseases
(RDs),
affecting
300
million
people
globally,
present
a
daunting
public
health
challenge
characterized
by
complexity,
limited
treatment
options,
and
diagnostic
hurdles.
Despite
legislative
efforts,
such
as
the
1983
US
Orphan
Drug
Act,
more
than
90%
of
RDs
lack
effective
therapies.
Traditional
drug
discovery
models,
marked
lengthy
development
cycles
high
failure
rates,
struggle
to
meet
unique
demands
RDs,
often
yielding
poor
returns
on
investment.
However,
advent
artificial
intelligence
(AI),
encompassing
machine
learning
(ML)
deep
(DL),
offers
groundbreaking
solutions.
This
review
explores
AI's
potential
revolutionize
for
overcoming
these
challenges.
It
discusses
AI-driven
advancements,
repurposing,
biomarker
discovery,
personalized
medicine,
genetics,
clinical
trial
optimization,
corporate
innovations,
novel
target
identification.
By
synthesizing
current
knowledge
recent
breakthroughs,
this
provides
crucial
insights
into
how
AI
can
accelerate
therapeutic
ultimately
improving
patient
outcomes.
comprehensive
analysis
fills
critical
gap
in
literature,
enhancing
understanding
pivotal
role
transforming
RD
research
guiding
future
efforts
vital
area
medicine.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 7, 2025
Cancer's
epigenetic
landscape,
a
labyrinthine
tapestry
of
molecular
modifications,
has
long
captivated
researchers
with
its
profound
influence
on
gene
expression
and
cellular
fate.
This
review
discusses
the
intricate
mechanisms
underlying
cancer
epigenetics,
unraveling
complex
interplay
between
DNA
methylation,
histone
chromatin
remodeling,
non-coding
RNAs.
We
navigate
through
tumultuous
seas
dysregulation,
exploring
how
these
processes
conspire
to
silence
tumor
suppressors
unleash
oncogenic
potential.
The
narrative
pivots
cutting-edge
technologies,
revolutionizing
our
ability
decode
epigenome.
From
granular
insights
single-cell
epigenomics
holistic
view
offered
by
multi-omics
approaches,
we
examine
tools
are
reshaping
understanding
heterogeneity
evolution.
also
highlights
emerging
techniques,
such
as
spatial
long-read
sequencing,
which
promise
unveil
hidden
dimensions
regulation.
Finally,
probed
transformative
potential
CRISPR-based
epigenome
editing
computational
analysis
transmute
raw
data
into
biological
insights.
study
seeks
synthesize
comprehensive
yet
nuanced
contemporary
landscape
future
directions
research.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: April 8, 2025
Modern
healthcare
depends
fundamentally
on
clinical
biochemistry
for
disease
diagnosis
and
therapeutic
guidance.
The
discipline
encounters
operational
constraints,
including
sampling
inefficiencies,
precision
limitations,
expansion
difficulties.
Recent
advancements
in
established
technologies,
such
as
mass
spectrometry
the
development
of
high-throughput
screening
point-of-care
are
revolutionizing
industry.
biosensor
technology
wearable
monitors
facilitate
continuous
health
tracking,
Artificial
Intelligence
(AI)/machine
learning
(ML)
applications
enhance
analytical
capabilities,
generating
predictive
insights
individualized
treatment
protocols.
However,
concerns
regarding
algorithmic
bias,
data
privacy,
lack
transparency
decision-making
("black
box"
models),
over-reliance
automated
systems
pose
significant
challenges
that
must
be
addressed
responsible
AI
integration.
limitations
remain-substantial
implementation
expenses,
system
incompatibility
issues,
information
security
vulnerabilities
intersect
with
ethical
considerations
fairness
protected
information.
Addressing
these
demands
coordinated
efforts
between
clinicians,
scientists,
technical
specialists.
This
review
discusses
current
biochemistry,
explicitly
addressing
reference
intervals
barriers
to
implementing
innovative
biomarkers
medical
settings.
discussion
evaluates
how
advanced
technologies
multidisciplinary
collaboration
can
overcome
constraints
while
identifying
research
priorities
diagnostic
accessibility
better
delivery.
Clinical Microbiology Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
SUMMARY
Recent
advances
in
therapeutic
probiotics
have
shown
promising
results
across
various
health
conditions,
reflecting
a
growing
understanding
of
the
human
microbiome’s
role
and
disease.
However,
comprehensive
reviews
integrating
diverse
effects
subjects
been
limited.
By
analyzing
randomized
controlled
trials
(RCTs)
meta-analyses,
this
review
provides
overview
key
developments
probiotic
interventions
targeting
gut,
liver,
skin,
vaginal,
mental,
oral
health.
Emerging
evidence
supports
efficacy
specific
strains
combinations
treating
wide
range
disorders,
from
gastrointestinal
(GI)
liver
diseases
to
dermatological
bacterial
vaginosis,
mental
diseases.
We
discuss
expanding
microbiome-organ
connections
underlying
mechanisms
action.
While
many
clinical
demonstrate
significant
benefits,
we
acknowledge
areas
requiring
further
large-scale
studies
establish
definitive
optimal
treatment
protocols.
The
addresses
challenges
standardizing
research
methodologies
emphasizes
importance
considering
individual
variations
microbiome
composition
host
genetics.
Additionally,
explore
emerging
concepts
such
as
oral-gut-brain
axis
future
directions,
including
high-resolution
profiling,
host-microbe
interaction
studies,
organoid
models,
artificial
intelligence
applications
research.
Overall,
offers
update
on
current
state
multiple
domains
health,
providing
insights
into
directions
potential
for
revolutionize
preventive
medicine.
