Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Creative Commons
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life. Short Summary Fusions between mismatch evolved multiple times Eukaryotes show evidence providing insight into forces shaping

Language: Английский

Characterizing the Rates and Patterns of De Novo Germline Mutations in the Aye-Aye (Daubentonia madagascariensis) DOI Creative Commons
Cyril J. Versoza, Erin E. Ehmke, Jeffrey D. Jensen

et al.

Molecular Biology and Evolution, Journal Year: 2025, Volume and Issue: 42(3)

Published: March 1, 2025

Given the many levels of biological variation in mutation rates observed to date primates-spanning from species individuals genomic regions-future steps our understanding rate evolution will not only be aided by a greater breadth coverage across primate clade but also depth as afforded an evaluation multiple trios within individual species. In order help bridge these gaps, we here present analysis representing one most basal splits on tree (aye-ayes), combining whole-genome sequencing seven parent-offspring three-generation pedigree with novel computational pipeline that takes advantage recently developed pan-genome graphs, thereby circumventing application (highly subjective) quality metrics has previously been shown result notable differences detection de novo mutations and ultimately estimates rates. This deep sampling enabled both detailed picture parental age effects sex dependency rates, which compare studied primates, provided unique insights into nature genetic endangered primates planet.

Language: Английский

Citations

1
Characterizing the rates and patterns ofde novogermline mutations in the aye-aye (Daubentonia madagascariensis) DOI Creative Commons
Cyril J. Versoza, Erin E. Ehmke, Jeffrey D. Jensen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Given the many levels of biological variation in mutation rates observed to date primates - spanning from species individuals genomic regions future steps our understanding rate evolution will be aided by both a greater breadth coverage across primate clade, but also depth as afforded an evaluation multiple trios within individual species. In order help bridge these gaps, we here present analysis representing one most basal splits on tree (aye-ayes), combining whole-genome sequencing seven parent-offspring three-generation pedigree with novel computational pipeline that takes advantage recently developed pan-genome graphs, thereby circumventing application (highly subjective) quality metrics has previously been shown result notable differences detection

Language: Английский

Citations

7
Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Open Access
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

Published: April 17, 2025

Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life.

Language: Английский

Citations

0
Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Open Access
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

Published: April 17, 2025

Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life.

Language: Английский

Citations

0
Convergent evolution of epigenome recruited DNA repair across the Tree of Life DOI Creative Commons
J. Grey Monroe, Chaehee Lee, Daniela Quiroz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, mechanistic diversity, and of epigenome-targeted systems across tree life remain unresolved. Here, we investigated histone reader domains fused to protein MSH6 (MutS Homolog 6) over 4,000 eukaryotes. We uncovered a paradigmatic example convergent evolution: has independently acquired distinct domains; PWWP (metazoa) Tudor (plants), previously shown target modifications in active genes humans (H3K36me3) Arabidopsis (H3K4me1). Conservation shows signatures natural selection, particularly for amino acids that bind specific modifications. Species have gained or retained readers tend larger genome sizes, especially marked by significantly more introns genic regions. These patterns support previous theoretical predictions about co-evolution architectures mutation rate heterogeneity. The implications evolution, health, mutational origins genetic diversity life. Short Summary Fusions between mismatch evolved multiple times Eukaryotes show evidence providing insight into forces shaping

Language: Английский

Citations

0