Neurotherapeutics, Journal Year: 2022, Volume and Issue: 19(3), P. 942 - 976
Published: April 1, 2022
Language: Английский
Nature Protocols, Journal Year: 2022, Volume and Issue: 17(1), P. 95 - 128
Published: Jan. 1, 2022
Language: Английский
Citations
150
Neural Plasticity, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 10
Published: Dec. 6, 2021
The blood-brain barrier (BBB) is a semipermeable and extremely selective system in the central nervous of most vertebrates, that separates blood from brain's extracellular fluid. It plays vital role regulating transport necessary materials for brain function, furthermore, protecting it foreign substances could damage it. In this review, we searched Google Scholar, Pubmed, Web Science, Saudi Digital Library various cells components support development function barrier, as well different pathways to molecules between brain. We also discussed aspects lead BBB dysfunction its neuropathological consequences, with identification some important biomarkers might be used biomarker predict disturbances. This comprehensive overview will pave way future studies focus on developing more specific targeting systems material delivery approach assists combinatorial therapy or nanotherapy destroy modify pathological conditions such tumors stem cell carcinomas.
Language: Английский
Citations
144
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114822 - 114822
Published: April 21, 2023
Central nervous system (CNS) disorders affect as many 1.5 billion people globally. The limited delivery of most imaging and therapeutic agents into the brain is a major challenge for treatment CNS disorders. With advent nanotechnologies, controlled drugs with nanoparticles holds great promise in overcoming blood-brain barrier (BBB) improving efficacy. In recent years, magnetic iron oxide (MIONPs) have stood out promising theranostic nanoplatform drug they possess unique physical properties biodegradable characteristics. this review, we summarize advances MIONP-based platforms diseases. We firstly introduce methods synthesis surface functionalization MIONPs emphasis on inclusion biocompatible polymers that allow addition tailored physicochemical properties. then discuss vivo applications using MIONPs. Finally, present perspective remaining challenges possible future directions systems.
Language: Английский
Citations
115
Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(23)
Published: June 1, 2022
The blood–brain barrier represents a significant challenge for the treatment of high-grade gliomas, and our understanding drug transport across this critical biointerface remains limited. To advance preclinical therapeutic development there is an urgent need predictive in vitro models with realistic blood–brain-barrier vasculature. Here, we report vascularized human glioblastoma multiforme (GBM) model microfluidic device that accurately recapitulates brain tumor vasculature self-assembled endothelial cells, astrocytes, pericytes to investigate targeted nanotherapeutics into GBM cells. Using modular layer-by-layer assembly, functionalized surface nanoparticles GBM-targeting motifs improve trafficking tumors. We directly compared nanoparticle platform mouse capillaries using intravital imaging, validating ability vivo transport. investigated potential by encapsulating cisplatin showed improved efficacy these GBM-targeted both orthotopic xenograft model. Our biomaterials advance, enabling in-depth investigation accelerating nanotherapeutics.
Language: Английский
Citations
86
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115115 - 115115
Published: Oct. 14, 2023
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They been used many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer, anti-microbial theranostic applications are especially prominent due to their exceptional performance deliver small molecules recently biologics (mRNA, siRNA, antigens, antibodies, proteins, peptides) at targeted sites. The physical chemical properties such as large specific surface area, tuneable particle size porosity, excellent biodegradability biocompatibility make them an ideal delivery diagnostic platform. Based on available data pre-clinical SNP, interest has driven these innovative materials towards clinical application with formulations already Phase I II trials. Herein, progress field is reviewed, safety aspects analysed. Importantly, we critically evaluate key structural characteristics overcome biological barriers blood-brain barrier (BBB), skin, tumour mucosal barrier. Future directions, potential pathways, target areas rapid translation also recommended.
Language: Английский
Citations
86
Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 475 - 496
Published: Sept. 9, 2023
In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various functions. This comprehensive review delves into examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical biochemical properties ECMs. We discuss potential integration these ECM-mimics range physiological pathological vitro models, enhancing our understanding behavior organization. Lastly, we propose future research directions for context engineering organ-on-a-chip applications, offering advancements therapeutic approaches improved patient outcomes.
Language: Английский
Citations
59
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2599 - 2599
Published: Nov. 7, 2023
Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is tightly packed layer of endothelial cells that shields brain from harmful substances blood, allowing necessary nutrients to pass through. It highly selective barrier, which poses challenge delivering therapeutic agents into brain. Several non-invasive procedures and devices have been developed or are currently being investigated enhance BBB. This paper presents review prospective analysis art science address pharmacology, technology, systems, regulatory approval, ethical concerns, future possibilities.
Language: Английский
Citations
44
Cell stem cell, Journal Year: 2024, Volume and Issue: 31(6), P. 818 - 833.e11
Published: May 15, 2024
Language: Английский
Citations
40
Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 31, 2024
Abstract Owing to unique facets, such as large surface area, tunable synthesis parameters, and ease of functionalization, mesoporous silica nanoparticles (MSNs) have transpired a worthwhile platform for cancer theranostics over the last decade. The full potential MSNs in theranostics, however, is yet be realized. While can employed targeted drug delivery imaging, their effectiveness frequently hindered by factors, biological barriers, complex tumor microenvironment, target non-specificity ineffectiveness individual functionalized moieties. primary purpose this review highlight technological advances tumor-specific, stimuli-responsive “smart” multimodal MSN-based hybrid nanoplatforms that overcome these limitations improve MSN theranostics. This article offers an extensive overview technology outlining key directions future research well challenges are involved aspect. We aim underline vitality relevance current advancements field potentially enhance clinical outcomes through provision more precise focused theranostic approaches.
Language: Английский
Citations
23
Journal of Chemical Information and Modeling, Journal Year: 2024, Volume and Issue: 64(10), P. 4298 - 4309
Published: May 3, 2024
The intricate nature of the blood–brain barrier (BBB) poses a significant challenge in predicting drug permeability, which is crucial for assessing central nervous system (CNS) efficacy and safety. This research utilizes an innovative approach, classification read-across structure–activity relationship (c-RASAR) framework, that leverages machine learning (ML) to enhance accuracy BBB permeability predictions. c-RASAR framework seamlessly integrates principles from both QSAR methodologies, underscoring need consider similarity-related aspects during development model. It note primary goal this not introduce yet another model but rather showcase refinement organic compounds through introduction approach. groundbreaking methodology aims elevate neuropharmacological implications streamline process development. In study, ML-based linear discriminant analysis (LDA) was developed using dataset 7807 compounds, encompassing BBB-permeable -nonpermeable substances sourced B3DB database (freely accessible https://github.com/theochem/B3DB), lead discovery CNS drugs. model's predictive capability then validated three external sets: one containing 276,518 natural products (NPs) LOTUS (accessible https://lotus.naturalproducts.net/download) data gap filling, comprising 13,002 drug-like/drug DrugBank (available https://go.drugbank.com/), third set 56 FDA-approved drugs assess reliability. Further diversifying arsenal, various other models were also comparison purposes. proposed emerged as powerful tool permeability. only advances understanding molecular determinants influencing provides versatile computational platform rapid assessment diverse facilitating informed decision-making design.
Language: Английский
Citations
18