Cryptochrome 1 mediates light-dependent inclination magnetosensing in monarch butterflies DOI Creative Commons
Guijun Wan, Ashley Hayden,

Samantha E. Iiams

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Feb. 3, 2021

Abstract Many animals use the Earth’s geomagnetic field for orientation and navigation. Yet, molecular cellular underpinnings of magnetic sense remain largely unknown. A biophysical model proposed that magnetoreception can be achieved through quantum effects magnetically-sensitive radical pairs formed by photoexcitation cryptochrome (CRY) proteins. Studies in Drosophila are only ones to date have provided compelling evidence ultraviolet (UV)-A/blue light-sensitive type 1 CRY (CRY1) involvement animal magnetoreception, surprisingly extended this discovery light-insensitive mammalian-like 2 CRYs (CRY2s) both monarchs humans. Here, we show respond a reversal inclination an UV-A/blue light CRY1, but not CRY2, dependent manner. We further demonstrate antennae eyes, which express magnetosensory organs. Our work argues function light-dependent inclination-based sensing.

Language: Английский

Long-distance navigation and magnetoreception in migratory animals DOI
Henrik Mouritsen

Nature, Journal Year: 2018, Volume and Issue: 558(7708), P. 50 - 59

Published: May 25, 2018

Language: Английский

Citations

444
Magnetic sensitivity of cryptochrome 4 from a migratory songbird DOI
Jingjing Xu, Lauren E. Jarocha,

Tilo Zollitsch

et al.

Nature, Journal Year: 2021, Volume and Issue: 594(7864), P. 535 - 540

Published: June 23, 2021

Language: Английский

Citations

290
Double-Cone Localization and Seasonal Expression Pattern Suggest a Role in Magnetoreception for European Robin Cryptochrome 4 DOI Creative Commons
Anja Günther, Angelika Einwich, Emil Sjulstok

et al.

Current Biology, Journal Year: 2018, Volume and Issue: 28(2), P. 211 - 223.e4

Published: Jan. 1, 2018

Language: Английский

Citations

178
Recent Advances in Magnetic Field-Enhanced Electrocatalysis DOI
Yuanyuan Zhang, Ce Liang, Jie Wu

et al.

ACS Applied Energy Materials, Journal Year: 2020, Volume and Issue: 3(11), P. 10303 - 10316

Published: Nov. 3, 2020

Magnetic field-enhanced electrocatalysis has recently emerged as an advanced strategy with great application prospects for highly efficient energy conversion and storage. Directly or indirectly, the magnetic effect been proved positive in various electrochemical reactions. This review starts from a brief introduction analysis to possible mechanisms (magnetothermal effect, magnetohydrodynamic Maxwell stress Kelvin force spin selectivity effect) of electrocatalysis. The recent advances reactions, including hydrogen evolution reaction, oxygen reduction CO2 are comprehensively summarized. ends up perspectives on future research taking advantage enhanced

Language: Английский

Citations

177
Electrochemistry in Magnetic Fields DOI
Songzhu Luo, Kamal Elouarzaki, Zhichuan J. Xu

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: April 25, 2022

Developing new strategies to advance the fundamental understanding of electrochemistry is crucial mitigating multiple contemporary technological challenges. In this regard, magnetoelectrochemistry offers many strategic advantages in controlling and electrochemical reactions that might be tricky regulate conventional fields. However, topic highly interdisciplinary, combining concepts from electrochemistry, hydrodynamics, magnetism with experimental outcomes are sometimes unexpected. Review, we survey recent advances using a magnetic field different applications organized by effect generated forces on principles focus how leads observed results. Finally, discuss challenges remain addressed establish robust capable meeting present needs.

Language: Английский

Citations

147
Quantum Biology: An Update and Perspective DOI Creative Commons
Youngchan Kim,

Federico Bertagna,

Edeline M. D’Souza

et al.

Quantum Reports, Journal Year: 2021, Volume and Issue: 3(1), P. 80 - 126

Published: Jan. 26, 2021

Understanding the rules of life is one most important scientific endeavours and has revolutionised both biology biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range complex dynamic biological processes which living systems could exploit quantum behaviour enhance regulate functions. Recent evidence suggests that these non-trivial mechanical effects may play crucial role maintaining non-equilibrium state biomolecular systems. Quantum study such aspects In this review, we summarise latest progress biology, including areas enzyme-catalysed reactions, photosynthesis, spin-dependent DNA, fluorescent proteins, ion channels. Many results are expected be fundamental building blocks towards understanding life.

Language: Английский

Citations

137
Magnetic field effects in biology from the perspective of the radical pair mechanism DOI Creative Commons
Hadi Zadeh‐Haghighi, Christoph Simon

Journal of The Royal Society Interface, Journal Year: 2022, Volume and Issue: 19(193)

Published: Aug. 1, 2022

Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, energies implicated in effects are much smaller than thermal energies. Here, we review observations, and suggest an explanation based on radical pair mechanism, which involves quantum dynamics electron nuclear spins transient molecules. While mechanism has been studied detail context avian magnetoreception, reviewed here show magnetosensitivity is widespread throughout biology. We field physiological functions, discussing static, hypomagnetic oscillating fields, as well isotope effects. then a potential unifying model for described effects, discuss plausible candidate molecules pairs. recent proposing provides explanations xenon anaesthesia lithium treatment hyperactivity, circadian clock, neurogenesis microtubule assembly. conclude by future lines investigation this exciting new area

Language: Английский

Citations

126
A Review of the Current State of Magnetic Force Microscopy to Unravel the Magnetic Properties of Nanomaterials Applied in Biological Systems and Future Directions for Quantum Technologies DOI Creative Commons
Robert Winkler,

M. Ciria,

Margaret Ahmad

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(18), P. 2585 - 2585

Published: Sept. 18, 2023

Magnetism plays a pivotal role in many biological systems. However, the intensity of magnetic forces exerted between bodies is usually low, which demands development ultra-sensitivity tools for proper sensing. In this framework, force microscopy (MFM) offers excellent lateral resolution and possibility conducting single-molecule studies like other single-probe (SPM) techniques. This comprehensive review attempts to describe paramount importance applications by highlighting MFM's main advantages but also intrinsic limitations. While working principles are described depth, article focuses on novel micro- nanofabrication procedures MFM tips, enhance response signal tested biomaterials compared commercial nanoprobes. work depicts some relevant examples where can quantitatively assess performance nanomaterials involved systems, including magnetotactic bacteria, cryptochrome flavoproteins, nanoparticles that interact with animal tissues. Additionally, most promising perspectives field highlighted make reader aware upcoming challenges when aiming toward quantum technologies.

Language: Английский

Citations

57
Essential elements of radical pair magnetosensitivity in Drosophila DOI Creative Commons
Adam A. Bradlaugh, Giorgio Fedele,

Anna L. Munro

et al.

Nature, Journal Year: 2023, Volume and Issue: 615(7950), P. 111 - 116

Published: Feb. 22, 2023

Abstract Many animals use Earth’s magnetic field (also known as the geomagnetic field) for navigation 1 . The favoured mechanism magnetosensitivity involves a blue-light-activated electron-transfer reaction between flavin adenine dinucleotide (FAD) and chain of tryptophan residues within photoreceptor protein CRYPTOCHROME (CRY). spin-state resultant radical pair, therefore concentration CRY in its active state, is influenced by 2 However, canonical CRY-centric radical-pair does not explain many physiological behavioural observations 2–8 Here, using electrophysiology analyses, we assay magnetic-field responses at single-neuron organismal levels. We show that 52 C-terminal amino acid Drosophila melanogaster CRY, lacking FAD-binding domain chain, are sufficient to facilitate magnetoreception. also increasing intracellular FAD potentiates both blue-light-induced magnetic-field-dependent effects on activity mediated C terminus. High levels alone cause blue-light neuronal sensitivity and, notably, potentiation this response co-presence field. These results reveal essential components primary magnetoreceptor flies, providing strong evidence non-canonical (that is, non-CRY-dependent) pairs can elicit cells.

Language: Английский

Citations

47
Molecular Ratchets and Kinetic Asymmetry: Giving Chemistry Direction DOI Creative Commons
Stefan Borsley, David A. Leigh, Benjamin M. W. Roberts

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(23)

Published: April 3, 2024

Abstract Over the last two decades ratchet mechanisms have transformed understanding and design of stochastic molecular systems—biological, chemical physical—in a move away from mechanical macroscopic analogies that dominated thinking regarding dynamics in 1990s early 2000s (e.g. pistons, springs, etc), to more scale‐relevant concepts underpin out‐of‐equilibrium research sciences today. Ratcheting has established nanotechnology as frontier for energy transduction metabolism, enabled reverse engineering biomolecular machinery, delivering insights into how molecules ‘walk’ track‐based synthesisers operate, acceleration reactions enables be transduced by catalysts (both motor proteins synthetic catalysts), dynamic systems can driven equilibrium through catalysis. The recognition biology, their invention systems, is proving significant areas diverse supramolecular chemistry, covalent DNA nanotechnology, polymer materials science, heterogeneous catalysis, endergonic synthesis, origin life, many other branches science. Put simply, give chemistry direction. Kinetic asymmetry, key feature ratcheting, counterpart structural asymmetry (i.e. chirality). Given ubiquity processes significance behaviour function it surely just fundamentally important. This Review charts recognition, development ratchets, focussing particularly on role which they were originally envisaged elements machinery. Different kinetically asymmetric are compared, consequences discussed. These archetypal examples demonstrate inexorably equilibrium, rather than relax towards it.

Language: Английский

Citations

35