Breaking Left–Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia DOI Creative Commons

De‐Li Shi

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2116 - 2116

Published: Dec. 20, 2024

The formation of the embryonic left–right axis is a fundamental process in animals, which subsequently conditions both shape and correct positioning internal organs. During vertebrate early development, transient structure, known as organizer, breaks bilateral symmetry manner that critically dependent on activity motile immotile cilia or asymmetric cell migration. Extensive studies have partially elucidated molecular pathways initiate patterning morphogenesis. Wnt/planar polarity signaling plays an important role biased orientation rotational motion cilia. leftward fluid flow generated cavity organizer sensed by through complex mechanisms to trigger left-sided calcium lateralized gene expression pattern. Disrupted impaired structure function leads randomized determination, closely linked laterality defects, particularly congenital heart disease. Despite formidable progress made deciphering critical contribution establishing asymmetry, strong challenge remains understand how generate sense differentially activate across axis. This review analyzes underlying morphogenesis formation. It also aims identify questions are open for future investigations.

Language: Английский

Comparative transcriptomic analysis of left-right sensory differences in Haliotis discus hannai DOI
Haifeng Huang,

Lintao Tan,

Lei Wei

et al.

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: 54, P. 101417 - 101417

Published: Jan. 11, 2025

Language: Английский

Citations

0
Identification of novel biallelic mutations in CFAP53 associated with fetal situs inversus totalis and literature review DOI
Zhenglong Guo,

Mengyao Tan,

Hongjie Zhu

et al.

Journal of Applied Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Breaking Left–Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia DOI Creative Commons

De‐Li Shi

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2116 - 2116

Published: Dec. 20, 2024

The formation of the embryonic left–right axis is a fundamental process in animals, which subsequently conditions both shape and correct positioning internal organs. During vertebrate early development, transient structure, known as organizer, breaks bilateral symmetry manner that critically dependent on activity motile immotile cilia or asymmetric cell migration. Extensive studies have partially elucidated molecular pathways initiate patterning morphogenesis. Wnt/planar polarity signaling plays an important role biased orientation rotational motion cilia. leftward fluid flow generated cavity organizer sensed by through complex mechanisms to trigger left-sided calcium lateralized gene expression pattern. Disrupted impaired structure function leads randomized determination, closely linked laterality defects, particularly congenital heart disease. Despite formidable progress made deciphering critical contribution establishing asymmetry, strong challenge remains understand how generate sense differentially activate across axis. This review analyzes underlying morphogenesis formation. It also aims identify questions are open for future investigations.

Language: Английский

Citations

0