Biophysical determinants of nuclear shape and mechanics and their implications for genome integrity

Current Opinion in Biomedical Engineering, Journal Year: 2024, Volume and Issue: 30, P. 100521 - 100521

Published: Jan. 26, 2024

Language: Английский

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Collective effects of cell cleavage dynamics

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 15, 2024

A conserved process of early embryonic development in metazoans is the reductive cell divisions following oocyte fertilization, termed cleavages. Cell cleavage cycles usually start synchronously, lengthen differentially between cells becoming asynchronous, and cease before major morphogenetic events, such as germ layer formation gastrulation. Despite exhibiting species-specific characteristics, regulation dynamics comes down to common controllers acting mostly at single cell/nucleus level, nucleus-to-cytoplasmic ratio zygotic genome activation. Remarkably, recent work has linked emergence collective behavior during embryogenesis, including pattern changes embryo-scale mechanics, raising question how single-cell coordinate processes. In this review, we summarize studies across species where an association cleavages was made, discuss underlying mechanisms, propose that cell-to-cell variability can serve a mechanism long-range coordination developing embryos.

Language: Английский

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Comparative study on the blood physiological, biochemical indexes and liver histology of Schizothorax wangchiachii (♀), Percocypris pingi (♂) and their hybrids

Frontiers in Marine Science, Journal Year: 2024, Volume and Issue: 11

Published: June 27, 2024

Distant hybridization is a well-established technique in genetic breeding for cultivation of superior traits. Previous studies have shown that, hybrids derived from the cross between Schizothorax wangchiachii (♀) and Percocypris pingi (♂) are significantly different their parents terms growth performance, feeding behavior disease resistance. Both cellular plasma components blood integral to immune system, erythrocytes serve as sole cells transporting oxygen which makes energy available growth, development, responses all other physiological activities. In order understand ecological adaptive strategies also underlying biochemical mechanisms fish with characteristics, present study used offsprings produced by artificial reproduction same batch domesticated S. , P. broodstock experimental fish, analyses indexes, differential leucocytes counts histological examination liver sections were performed. Results showed that proportions lymphocytes thrombocytes higher than those (P<0.05), while granulocytes monocytes (P<0.05). contrast, cell values fell its parent species, exception percentage thrombocytes, was highest three. The erythrocyte area, perimeter short diameter hybrid (P<0.0001), exhibited smallest values. Hepatocyte had hepatocyte perimeter, long diameter. However, size hepatic nucleus smallest. number Kupffer per unit area greater markers, C-reactive protein level nearly undetectable but it could reach 10 mg/L both hybrids. Besides, total bile acids (P<0.01), intermediate level. These results suggest there may be differences functions among hybrids, well metabolism synthesis capabilities. findings here might provide some crucial clues understanding biodiversity adaptation, further promote development wild cultivation.

Language: Английский

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Lineage-based scaling of germline intercellular bridges during oogenesis

Development, Journal Year: 2024, Volume and Issue: 151(16)

Published: Aug. 15, 2024

ABSTRACT The size of subcellular structures must be tightly controlled to maintain normal cell function. Despite its importance, few studies have determined how the organelles or other is maintained during development, when cells are growing, dividing and rearranging. developing Drosophila egg chamber a powerful model in which study relative growth rates structures. contains cluster 16 germline cells, connected through intercellular bridges called ring canals. As grows, canals that connect them increase size. Here, we demonstrate canal scaling related lineage; largest, ‘first-born’ at relatively slower rate than derived from subsequent mitotic divisions. This lineage-based relationship even if directed transport reduced, altered, chambers with twice as many cells. Analysis lines produce larger smaller mature eggs reveals different strategies could used alter final

Language: Английский

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The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus

Nature Reviews Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

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