Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity DOI
Susan N. Christo, Maximilien Evrard, Simone L. Park

et al.

Nature Immunology, Journal Year: 2021, Volume and Issue: 22(9), P. 1140 - 1151

Published: Aug. 23, 2021

Language: Английский

Regulation of immune responses by the airway epithelial cell landscape DOI Open Access
Richard Hewitt, Clare M. Lloyd

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(6), P. 347 - 362

Published: Jan. 13, 2021

Language: Английский

Citations

370
Tissue Determinants of Human NK Cell Development, Function, and Residence DOI Creative Commons
Pranay Dogra, Chiara Rancan, Wenji Ma

et al.

Cell, Journal Year: 2020, Volume and Issue: 180(4), P. 749 - 763.e13

Published: Feb. 1, 2020

Language: Английский

Citations

330
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19 DOI Creative Commons
Alba Grifoni, John Sidney, Randi Vita

et al.

Cell Host & Microbe, Journal Year: 2021, Volume and Issue: 29(7), P. 1076 - 1092

Published: May 21, 2021

Language: Английский

Citations

299
Cross-reactive memory T cells and herd immunity to SARS-CoV-2 DOI Creative Commons
Marc Lipsitch, Yonatan H. Grad, Alessandro Sette

et al.

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 20(11), P. 709 - 713

Published: Oct. 6, 2020

Language: Английский

Citations

264
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease DOI
David Goldblatt, Galit Alter, Shane Crotty

et al.

Immunological Reviews, Journal Year: 2022, Volume and Issue: 310(1), P. 6 - 26

Published: June 5, 2022

Antibodies against epitopes in S1 give the most accurate CoP infection by SARS-CoV-2 coronavirus. Measurement of those antibodies neutralization or binding assays both have predictive value, with antibody titers giving highest statistical correlation. However, protective functions are multiple. multiple other than influence efficacy. The role cellular responses can be discerned respect to CD4

Language: Английский

Citations

244
Tissue-resident memory T cells in breast cancer control and immunotherapy responses DOI
Ann Byrne, Peter Savas, Sneha Sant

et al.

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(6), P. 341 - 348

Published: Feb. 28, 2020

Language: Английский

Citations

238
Monalizumab: inhibiting the novel immune checkpoint NKG2A DOI Creative Commons
Thorbald van Hall,

Pascale André,

Amir Horowitz

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2019, Volume and Issue: 7(1)

Published: Oct. 17, 2019

The implementation of immune checkpoint inhibitors to the oncology clinic signified a new era in cancer treatment. After first indication melanoma, an increasing list additional types are now treated with system targeting antibodies PD-1, PD-L1 and CTLA-4, alleviating inhibition signals on T cells. Recently, we published proof-of-concept results novel inhibitor, NKG2A. This receptor is expressed cytotoxic lymphocytes, including NK cells subsets activated CD8+ Blocking NKG2A unleashed reactivity these effector resulting tumor control multiple mouse models early clinical trial. Monalizumab inhibiting this human beings future trials will have reveal its potency combination other treatment options.

Language: Английский

Citations

237
Developmental plasticity allows outside-in immune responses by resident memory T cells DOI
Raíssa Fonseca, Lalit K. Beura,

Clare F. Quarnstrom

et al.

Nature Immunology, Journal Year: 2020, Volume and Issue: 21(4), P. 412 - 421

Published: Feb. 17, 2020

Language: Английский

Citations

224
Understanding and treating the inflammatory adverse events of cancer immunotherapy DOI Creative Commons
Michael Dougan, Adrienne Luoma, Stephanie K. Dougan

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(6), P. 1575 - 1588

Published: March 1, 2021

Language: Английский

Citations

212
High-content CRISPR screening DOI
Christoph Bock, Paul Datlinger, Florence M. Chardon

et al.

Nature Reviews Methods Primers, Journal Year: 2022, Volume and Issue: 2(1)

Published: Feb. 10, 2022

Language: Английский

Citations

209