bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Interleukin-34
(IL34)
and
colony
stimulating
factor
1
(CSF1)
signal
through
a
shared
receptor
(CSF1R)
to
control
macrophage
survival,
differentiation
function.
Here
we
describe
the
impact
of
loss
function
mutation
in
rat
Il34
gene.
−/−
rats
showed
partial
reduction
macrophages
within
squamous
epithelia
(Langerhans-like
cells)
testis.
In
brain,
microglia
brain-associated
were
selectively
depleted
grey
matter.
A
gradient
microglial
density
cortex
suggests
that
CSF1
can
diffuse
outwards
from
corpus
callosum.
The
reduced
was
not
associated
with
detectable
neuropathology
or
behavioural
alterations.
RNA-seq
analysis
cortex,
hippocampus
thalamus
only
change
is
selective
uniform
signature.
periphery,
increased
expression
has
been
epithelial
injury.
adenine
diet
model
renal
interstitial
fibrosis
both
Csf1
induced.
absence
IL34
led
significant
recruitment
compared
controls,
but
pathology
assessed
histologically
by
detection
damage-associated
mRNA
signature
unaffected.
We
suggest
provide
redundant
signals
sustain
direct
repair
tissue
injury
periphery.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Jan. 3, 2023
Abstract
Obesity
is
one
of
the
most
serious
global
health
problems,
with
an
incidence
that
increases
yearly
and
coincides
development
cancer.
Adipose
tissue
macrophages
(ATMs)
are
particularly
important
in
this
context
contribute
to
linking
obesity-related
inflammation
tumor
progression.
However,
functions
ATMs
on
progression
obesity-associated
cancer
remain
unclear.
In
review,
we
describe
origins,
phenotypes,
ATMs.
Subsequently,
summarize
potential
mechanisms
reprogramming
microenvironment,
including
direct
exchange
dysfunctional
metabolites,
inordinate
cytokines
other
signaling
mediators,
transfer
extracellular
vesicle
cargo,
variations
gut
microbiota
its
metabolites.
A
better
understanding
properties
under
conditions
obesity
will
lead
new
therapeutic
interventions
for
Experimental Hematology and Oncology,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 16, 2024
Abstract
As
integral
components
of
the
immune
microenvironment,
tissue
resident
macrophages
(TRMs)
represent
a
self-renewing
and
long-lived
cell
population
that
plays
crucial
roles
in
maintaining
homeostasis,
promoting
remodeling
after
damage,
defending
against
inflammation
even
orchestrating
cancer
progression.
However,
exact
functions
TRMs
are
not
yet
well
understood.
exhibit
either
pro-tumorigenic
or
anti-tumorigenic
effects
by
engaging
phagocytosis
secreting
diverse
cytokines,
chemokines,
growth
factors
to
modulate
adaptive
system.
The
life-span,
turnover
kinetics
monocyte
replenishment
vary
among
different
organs,
adding
complexity
controversial
findings
studies.
Considering
associated
macrophage
origin,
targeting
strategy
each
ontogeny
should
be
carefully
evaluated.
Consequently,
acquiring
comprehensive
understanding
TRMs'
function,
characteristics,
their
for
specific
organ
holds
significant
research
value.
In
this
review,
we
aim
provide
an
outline
homeostasis
characteristics
lung,
liver,
brain,
skin
intestinal,
as
modulating
primary
metastatic
cancer,
which
may
inform
serve
future
design
targeted
therapies.
Cell Regeneration,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: June 11, 2024
Abstract
Macrophages
play
crucial
and
versatile
roles
in
regulating
tissue
repair
regeneration
upon
injury.
However,
due
to
their
complex
compositional
heterogeneity
functional
plasticity,
deciphering
the
nature
of
different
macrophage
subpopulations
unraveling
dynamics
precise
during
process
have
been
challenging.
With
its
distinct
advantages,
zebrafish
(Danio
rerio)
has
emerged
as
an
invaluable
model
for
studying
development
functions,
especially
regeneration,
providing
valuable
insights
into
our
understanding
biology
health
diseases.
In
this
review,
we
present
current
knowledge
challenges
associated
with
role
macrophages
highlighting
significant
contributions
made
by
studies.
We
discuss
unique
advantages
model,
including
genetic
tools,
imaging
techniques,
regenerative
capacities,
which
greatly
facilitated
investigation
these
processes.
Additionally,
outline
potential
research
addressing
remaining
advancing
intricate
interplay
between
regeneration.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Interleukin-34
(IL34)
and
colony
stimulating
factor
1
(CSF1)
signal
through
a
shared
receptor
(CSF1R)
to
control
macrophage
survival,
differentiation
function.
Here
we
describe
the
impact
of
loss
function
mutation
in
rat
Il34
gene.
−/−
rats
showed
partial
reduction
macrophages
within
squamous
epithelia
(Langerhans-like
cells)
testis.
In
brain,
microglia
brain-associated
were
selectively
depleted
grey
matter.
A
gradient
microglial
density
cortex
suggests
that
CSF1
can
diffuse
outwards
from
corpus
callosum.
The
reduced
was
not
associated
with
detectable
neuropathology
or
behavioural
alterations.
RNA-seq
analysis
cortex,
hippocampus
thalamus
only
change
is
selective
uniform
signature.
periphery,
increased
expression
has
been
epithelial
injury.
adenine
diet
model
renal
interstitial
fibrosis
both
Csf1
induced.
absence
IL34
led
significant
recruitment
compared
controls,
but
pathology
assessed
histologically
by
detection
damage-associated
mRNA
signature
unaffected.
We
suggest
provide
redundant
signals
sustain
direct
repair
tissue
injury
periphery.
