Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
Infected
bone
defects
are
a
common
clinical
condition,
but
conventional
treatments
often
fail
to
achieve
the
desired
outcomes,
including
addressing
antibiotic
resistance
and
preventing
nonunion
complications.
In
presented
study,
functionalized
decellularized
mushroom
stem
scaffold
is
developed
composed
of
its
naturally
aligned
channels,
Zn
2+
/curcumin
MOFs,
hydroxyapatite
minerals,
icariin.
vitro,
It
found
that
acellular
can
control
bacterial
infections
through
MOFs.
The
channels
guide
mesenchymal
cells
(BMSCs)
migration,
components
adsorbed
on
substrate
further
promote
migration
BMSCs.
Moreover,
these
functional
accelerated
polarization
M2
macrophage
osteogenic
differentiation
vivo,
cleared
infected
bacteria
within
3
days,
induced
extracellular
matrix
secretion
alignment,
promoted
new
formation
cover
8
weeks.
provides
promising
strategy
for
treating
infectious
defects.
IgMin Research,
Journal Year:
2025,
Volume and Issue:
3(1), P. 015 - 020
Published: Jan. 17, 2025
Background:
Zinc
deficiency
has
been
identified
as
a
contributing
factor
to
poor
appetite,
impaired
immune
function,
and
various
gastrointestinal
disturbances
in
young
children.
Objective:
To
assess
the
effect
of
zinc
supplementation
on
vomiting
status
anorexic
Methods:
A
randomized,
controlled,
single-blinded
clinical
trial.
Fifty
children
(3–36
months
old)
without
infection
gastro-intestinal
outlet
obstructions
were
selected
admission
nutrition
recovery
center:
25
(supplemented,
S
group)
received
10mg/child
daily
elemental
gluconate
with
iron
vitamins
supplemental
dosage,
(non-supplemented,
NS
similar
one
but
for
90
days.
All
also
observed
during
90-day
post-supplementation
period,
child
group
four
dropped
out.
On
days
7,
10,
15
was
assessed.
0
30,
levels
energy
intake
weight
gain
measured.
90,
serum
Results:
15,
healed
proportions
significantly
higher
(83.3%
vs.
0.0%;
87.5%
4.8%
95.5%
19%)
than
that
(p
<
0.001
each).
day
(108
±
20
82
16
Kcal/kg/day)
(414
120
248
102
g/child/mo)
Serum
(µg/dl)
(76.8
8.4
71.2
6.3,
p
0.05)
90.
Conclusion:
This
study
supports
role
protracted
not
due
children,
while
pointing
out
need
large
studies.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Abstract
Zinc
plays
a
central
role
in
the
hematological
development.
Therapeutic
interventions
with
zinc
are
shown
to
improve
health
status
of
patients
malignancies
by
stimulating
immune
system
and
reducing
side
effects.
Despite
abnormal
homeostasis
leukemia,
mechanisms
signaling
leukemia
development
remain
poorly
understood.
Recently,
some
important
breakthroughs
made
laboratory
clinical
studies
such
as
regulating
ferroptosis
effects
immunotherapy.
Zinc‐based
strategies
urgently
needed
refine
current
intervention
regimen
for
side‐effect
free
therapy
chemotherapy‐intolerant
patients.
This
review
provides
comprehensive
overview
focuses
on
therapeutic
potential
modulation
leukemia.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
Infected
bone
defects
are
a
common
clinical
condition,
but
conventional
treatments
often
fail
to
achieve
the
desired
outcomes,
including
addressing
antibiotic
resistance
and
preventing
nonunion
complications.
In
presented
study,
functionalized
decellularized
mushroom
stem
scaffold
is
developed
composed
of
its
naturally
aligned
channels,
Zn
2+
/curcumin
MOFs,
hydroxyapatite
minerals,
icariin.
vitro,
It
found
that
acellular
can
control
bacterial
infections
through
MOFs.
The
channels
guide
mesenchymal
cells
(BMSCs)
migration,
components
adsorbed
on
substrate
further
promote
migration
BMSCs.
Moreover,
these
functional
accelerated
polarization
M2
macrophage
osteogenic
differentiation
vivo,
cleared
infected
bacteria
within
3
days,
induced
extracellular
matrix
secretion
alignment,
promoted
new
formation
cover
8
weeks.
provides
promising
strategy
for
treating
infectious
defects.
