Macrophages as tools and targets in cancer therapy

Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(11), P. 799 - 820

Published: Aug. 16, 2022

Language: Английский

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Neutrophil diversity and plasticity in tumour progression and therapy

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(9), P. 485 - 503

Published: July 21, 2020

Language: Английский

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Clinical relevance of tumour-associated macrophages

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 19(6), P. 402 - 421

Published: March 30, 2022

Language: Английский

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Radiotherapy combined with immunotherapy: the dawn of cancer treatment

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 29, 2022

Abstract Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic effect on remote and non-irradiated tumor deposits, which called abscopal effect. The view RT as a simple treatment has dramatically changed in recent years, it now widely accepted that provoke immune response gives strong rationale the combination immunotherapy (iRT). Nevertheless, several points remain to be addressed such interaction system, identification best schedules with (IO), expansion mechanism amplify iRT. To answer these crucial questions, we roundly summarize underlying showing whole landscape clinical trials attempt identify In consideration rarity effect, propose occurrence induced by radiation promoted 100% molecular genetic level. Furthermore, “radscopal effect” refers using low-dose reprogram microenvironment may overcome resistance Taken together, could regarded trigger antitumor response, help IO used radical added into current standard regimen patients metastatic cancer.

Language: Английский

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Immunology of Aging: the Birth of Inflammaging

Clinical Reviews in Allergy & Immunology, Journal Year: 2021, Volume and Issue: 64(2), P. 109 - 122

Published: Sept. 18, 2021

Language: Английский

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Pathophysiology of Inflammatory Bowel Disease: Innate Immune System

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1526 - 1526

Published: Jan. 12, 2023

Inflammatory bowel disease (IBD), comprising Crohn’s (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause. Intestinal innate immunity enacted by neutrophils, monocytes, macrophages, dendritic cells (DCs), lymphoid NK cells, characterized their capacity to produce rapid nonspecific reaction as first-line response. Innate immune (IIC) defend against pathogens excessive entry microorganisms, while preserving tolerance resident microbiota. Changes this equilibrium are linked in the gut IBD. IICs mediate host defense responses, inflammation, tissue healing producing cytokines chemokines, activating complement cascade phagocytosis, or presenting antigens activate adaptive exert important functions that promote ameliorate cellular molecular mechanisms underlie sustain A comprehensive understanding underlying these clinical manifestations will be for developing therapies targeting system IBD patients. This review examines complex roles interactions among IICs, other non-immune homeostasis pathological conditions.

Language: Английский

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Liver macrophages in health and disease

Immunity, Journal Year: 2022, Volume and Issue: 55(9), P. 1515 - 1529

Published: Sept. 1, 2022

Language: Английский

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Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

Journal for ImmunoTherapy of Cancer, Journal Year: 2021, Volume and Issue: 9(1), P. e001341 - e001341

Published: Jan. 1, 2021

Macrophages are the most important phagocytes in vivo. However, tumor microenvironment can affect function and polarization of macrophages form tumor-associated (TAMs). Usually, abundance TAMs tumors is closely associated with poor prognosis. Preclinical studies have identified pathways regulating infiltration during progression. Furthermore, potential therapeutic strategies targeting been studied, including inhibition macrophage recruitment to tumors, functional repolarization toward an antitumor phenotype, other that elicit macrophage-mediated extracellular phagocytosis intracellular destruction cancer cells. Therefore, increasing impact immunotherapy, new target now being discussed.

Language: Английский

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Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

Bioactive Materials, Journal Year: 2021, Volume and Issue: 7, P. 47 - 72

Published: June 20, 2021

Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of infarction still high. Reperfusion injuries inevitable due the generation reactive oxygen species (ROS) apoptosis cardiac muscle cells. However, many antioxidant anti-inflammatory drugs largely limited by pharmacokinetics route administration, such as short half-life, low stability, bioavailability, side effects for treatment ischemia injury. Therefore, it is necessary develop effective technologies address this issue. Fortunately, nanotherapies have demonstrated great opportunities treating Compared with traditional drugs, nanodrugs can effectively increase therapeutic effect reduces improving pharmacokinetic pharmacodynamic properties nanodrugs' size, shape, material characteristics. In review, biology ROS molecular mechanisms injury discussed. Furthermore, we summarized applications ROS-based nanoparticles, highlighting latest achievements nanotechnology researches

Language: Английский

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Monocytes in the Tumor Microenvironment

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2021, Volume and Issue: 16(1), P. 93 - 122

Published: Jan. 24, 2021

Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature progressively shaped by systemic and local cues during tumor development. Monocytes bridge innate adaptive immune responses can affect microenvironment through various mechanisms that induce tolerance, angiogenesis, increased dissemination of cells. Yet monocytes also give rise antitumor effectors activate antigen-presenting This yin-yang activity relies on plasticity in response environmental stimuli. In this review, we summarize current knowledge ontogeny, heterogeneity, functions monocyte-derived cells cancer, pinpointing main pathways are important for modeling immunosuppressive microenvironment.

Language: Английский

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