Critical Care,
Journal Year:
2021,
Volume and Issue:
25(1)
Published: April 26, 2021
Abstract
Background
COVID-19
has
resulted
in
high
mortality
worldwide.
Information
regarding
cardiac
markers
for
precise
risk-stratification
is
limited.
We
aim
to
discover
sensitive
and
reliable
early-warning
biomarkers
optimizing
management
improving
the
prognosis
of
patients.
Methods
A
total
2954
consecutive
patients
who
were
receiving
treatment
from
Wuhan
Huoshenshan
Hospital
China
February
4
April
10
included
this
retrospective
cohort.
Serum
levels
collected
after
admission.
Coronary
artery
disease
diagnosis
survival
status
recorded.
Single-cell
RNA-sequencing
bulk
different
cohorts
non-COVID-19
performed
analyze
SARS-CoV-2
receptor
expression.
Results
Among
analysis,
median
age
was
60
years
(50–68
years),
1461
(49.5%)
female,
1515
(51.3%)
severe/critical.
Compared
mild/moderate
(1439,
48.7%)
patients,
severe/critical
showed
significantly
higher
within
first
week
In
those
with
abnormal
serum
BNP
(42
[24.6%]
vs
7
[1.1%]),
hs-TNI
(38
[48.1%]
6
[1.0%]),
α-
HBDH
(55
[10.4%]
2
[0.2%]),
CK-MB
(45
[36.3%]
12
[0.9%]),
LDH
(56
[12.5%]
1
[0.1%])
had
a
rate
compared
normal
levels.
The
same
trend
observed
ICU
admission
rate.
Severe/critical
pre-existing
coronary
(165/1,155
[10.9%])
more
cases
(52
[46.5%]
119
[16.5%]),
(24
[26.7%]
9.6
[%],
(86
[55.5%]
443
[34.4%]),
(27
[17.4%]
97
[7.5%]),
(65
[41.9%]
382
[29.7%]),
when
without
disease.
There
enhanced
expression
healthy
controls.
From
regression
five
elevated
at
risk
death
(hazards
ratio
3.4
[95%
CI
2.4–4.8]).
Conclusions
represented
percentage
markers,
accompanied
by
together
hs-TNI,
HBDH,
act
as
prognostic
biomarker
or
The Egyptian Journal of Internal Medicine,
Journal Year:
2025,
Volume and Issue:
37(1)
Published: Jan. 7, 2025
Abstract
Malaria,
though
witnessing
a
decline
in
prevalence,
remains
global
health
threat.
Despite
its
primarily
recognized
impact
on
the
hematological
system,
recent
studies
shed
light
severe
cardiac
complications,
particularly
myocarditis,
associated
with
Plasmodium
infections.
This
review
examines
literature
malaria-induced
myocarditis
to
elucidate
mechanisms,
clinical
manifestations,
regional
perspectives,
treatment
outcomes,
and
diagnostic
challenges.
A
search
spanning
PubMed,
Scopus,
Web
of
Science
identified
relevant
up
January
2024,
encompassing
case
reports,
cohort
studies,
trials,
experimental
studies.
The
relationship
between
malaria
myocardial
involvement
is
explored,
showcasing
elevated
biomarkers
indicative
damage.
Notably,
while
falciparum
traditionally
linked
instances
vivax
contributing
complications
are
documented.
Regional
perspectives
reveal
diverse
cases,
emphasizing
importance
considering
endemic
regions
beyond.
Treatment
outcomes
underscore
efficacy
timely
antimalarial
therapy,
advocating
for
integrated
approaches
patient
care.
Diagnostic
challenges,
often
complicated
by
overlapping
symptoms
other
conditions,
highlight
need
heightened
suspicion.
Addressing
therapeutic
challenges
involves
balancing
drugs,
supportive
care,
long-term
monitoring.
Future
research
directions
outlined,
necessity
understanding
host-parasite
interactions,
elucidating
molecular
developing
targeted
tools.
consolidates
current
knowledge
significance
continuous
vigilance,
research,
improved
mitigate
this
overlooked
complication.
APIK Journal of Internal Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
Abstract
The
current
research
examines
the
creation
of
biomarkers
for
measuring
cardiovascular
disease
(CVD)
risk
and
tracking
therapy
effectiveness.
While
like
cholesterol
levels
troponins
are
useful,
developing
innovating
new
gives
fresh
insights
into
CVD
etiology
drug
response.
limits
known
discussed,
leading
to
quest
signs
that
might
enhance
categorization
monitoring.
Advancements
in
multiomics
technologies,
such
as
genomics,
proteomics,
metabolomics,
transcriptomics,
have
been
utilized
uncover
possible
biomarkers,
offering
a
complete
perspective
molecular
pathways
implicated
CVD.
Artificial
intelligence
machine
learning
play
vital
role
biomarker
development
validation,
allowing
investigation
massive
omics
datasets
detecting
patterns
links
may
not
be
obvious
using
conventional
approaches.
clinical
translation
needs
comprehensive
validation
evaluation
their
efficacy
improving
patient
outcomes.
Incorporating
these
indicators
practice
boost
prediction,
modify
treatment
regimens,
improve
overall
care.
Frontiers in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 29, 2025
Objective
Clinical
practice
currently
faces
a
significant
shortfall
in
specific
biomarkers
needed
for
diagnosing
right
ventricular
(RV)
remodeling
patients
with
pulmonary
hypertension
(PH).
While
small
noncoding
microRNAs
(miRNAs)
are
crucial
regulators
of
RV
remodeling,
the
biomarker
potential
serum
miRNAs
this
process
is
little
known.
This
study
systematically
screened
and
identified
candidate
as
diagnostic
PH
patients.
Methods
Pulmonary
artery
banding
(PAB)
was
performed
Sprague-Dawley
(SD)
rats
modeling
measured
by
echocardiographic
histological
analyses
4
weeks
after
surgery.
High-throughput
miRNA
sequencing
samples
to
profile
differentially-expressed
(dif-miRNAs)
preliminarily
screen
miRNAs.
The
power
further
validated
100
[20
adaptive
pressure
overload;
20
maladaptive
left
heart
failure
(LHF);
19
hypertrophy
21
controls].
Results
PAB
exhibited
severe
hypertrophy,
fibrosis
enlargement
cardiomyocytes
compared
sham
group.
MiRNA
revealed
dif-miRNAs
(12
upregulated
7
downregulated)
between
two
groups.
Among
12
miRNAs,
miRNA-486
highest
elevation
group
supposed
be
modeling.
Serum
levels
were
lower
control
(LVH)
patients,
significantly
higher
maladapted
than
adapted
LHF
controls,
but
still
In
receiver
operating
characteristic
(ROC)
analysis,
good
predictor
maladaptation
(cut-off
value
3.441,
AUC
0.8625),
which
not
different
from
B-type
natriuretic
peptide
(BNP).
Elevated
(≥3.441)
associated
reduced
TAPSE/PASP
ratios
increased
BNP
levels.
Conclusions
has
valuable
noninvasive
PH.
Critical Care,
Journal Year:
2021,
Volume and Issue:
25(1)
Published: April 26, 2021
Abstract
Background
COVID-19
has
resulted
in
high
mortality
worldwide.
Information
regarding
cardiac
markers
for
precise
risk-stratification
is
limited.
We
aim
to
discover
sensitive
and
reliable
early-warning
biomarkers
optimizing
management
improving
the
prognosis
of
patients.
Methods
A
total
2954
consecutive
patients
who
were
receiving
treatment
from
Wuhan
Huoshenshan
Hospital
China
February
4
April
10
included
this
retrospective
cohort.
Serum
levels
collected
after
admission.
Coronary
artery
disease
diagnosis
survival
status
recorded.
Single-cell
RNA-sequencing
bulk
different
cohorts
non-COVID-19
performed
analyze
SARS-CoV-2
receptor
expression.
Results
Among
analysis,
median
age
was
60
years
(50–68
years),
1461
(49.5%)
female,
1515
(51.3%)
severe/critical.
Compared
mild/moderate
(1439,
48.7%)
patients,
severe/critical
showed
significantly
higher
within
first
week
In
those
with
abnormal
serum
BNP
(42
[24.6%]
vs
7
[1.1%]),
hs-TNI
(38
[48.1%]
6
[1.0%]),
α-
HBDH
(55
[10.4%]
2
[0.2%]),
CK-MB
(45
[36.3%]
12
[0.9%]),
LDH
(56
[12.5%]
1
[0.1%])
had
a
rate
compared
normal
levels.
The
same
trend
observed
ICU
admission
rate.
Severe/critical
pre-existing
coronary
(165/1,155
[10.9%])
more
cases
(52
[46.5%]
119
[16.5%]),
(24
[26.7%]
9.6
[%],
(86
[55.5%]
443
[34.4%]),
(27
[17.4%]
97
[7.5%]),
(65
[41.9%]
382
[29.7%]),
when
without
disease.
There
enhanced
expression
healthy
controls.
From
regression
five
elevated
at
risk
death
(hazards
ratio
3.4
[95%
CI
2.4–4.8]).
Conclusions
represented
percentage
markers,
accompanied
by
together
hs-TNI,
HBDH,
act
as
prognostic
biomarker
or
