Neutrophils versus Protozoan Parasites: Plasmodium, Trichomonas, Leishmania, Trypanosoma, and Entameoba DOI Creative Commons
Eileen Uribe‐Querol, Carlos Rosales

Microorganisms, Journal Year: 2024, Volume and Issue: 12(4), P. 827 - 827

Published: April 19, 2024

Neutrophils are the most abundant polymorphonuclear granular leukocytes in human blood and an essential part of innate immune system. efficient cells that eliminate pathogenic bacteria fungi, but their role dealing with protozoan parasitic infections remains controversial. At sites parasite infections, a large number infiltrating neutrophils is observed, suggesting important for controlling infection. Yet, cases, there also strong inflammatory response can provoke tissue damage. Diseases like malaria, trichomoniasis, leishmaniasis, Chagas disease, amoebiasis affect millions people globally. In this review, we summarize these diseases describe novel view on how involved protection from parasites. Also, present recent evidence play double participating both control pathogenesis disease.

Language: Английский

Recent advances in targeted therapy for inflammatory vascular diseases DOI
Kaiwen Zhao, Zan Zeng,

Yuzhen He

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 730 - 750

Published: July 3, 2024

Language: Английский

Citations

9
Adaptations of neutrophils in cancer DOI
Melissa Ng, Daniela Cerezo‐Wallis, Lai Guan Ng

et al.

Immunity, Journal Year: 2025, Volume and Issue: 58(1), P. 40 - 58

Published: Jan. 1, 2025

Language: Английский

Citations

1
Exploring Neutrophil Heterogeneity and Plasticity in Health and Disease DOI Creative Commons
Conny Gysemans,

Mateson Beya,

E.A. Pedace

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 597 - 597

Published: March 1, 2025

Neutrophils, the most abundant polymorphonuclear leukocytes, are critical first responders to infection, and have historically been underappreciated in terms of their functional complexity within immune response. Once viewed primarily as short-lived, innate cells with limited plasticity, recent research has illuminated considerable heterogeneity diverse roles, which extend beyond involvement steady-state immunity. This review seeks provide an updated analysis neutrophil development, maturation, heterogeneity, a focus on how these characteristics influence modulation both healthy diseased tissues. Beginning origin neutrophils, we explore maturation into effector evolving roles defense under homeostatic disease-associated conditions. We then delve discussing breakthroughs that challenge traditional view neutrophils uniform population. address significant advances made identifying distinct subsets, emerging complexities challenges remain fully understanding diversity. Finally, highlight future directions opportunities for continued exploration this rapidly advancing field, shedding light insights could open new avenues therapeutic interventions.

Language: Английский

Citations

1
Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver DOI Creative Commons
Mrigya Babuta, Prashanth Thevkar Nagesh, Aditi Ashish Datta

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 960 - 960

Published: June 1, 2024

Binge drinking in obese patients positively correlates with accelerated liver damage and liver-related death. However, the underlying mechanism effect of alcohol use on progression metabolic-dysfunction-associated steatotic disease (MASLD) remain unexplored. Here, we show that short-term feeding a steatohepatitis (MASH) diet plus daily acute binges for three days induce injury activation NLRP3 inflammasome. We identify MASH promote inflammation via increased infiltration monocyte-derived macrophages, neutrophil recruitment, NET release liver. Our results suggest both macrophages neutrophils are activated NLRP3, while administration MCC950, an inhibitor, dampens these effects.In this study, reveal important intercellular communication between hepatocytes neutrophils. discover induces IL-1β acts promotes production CXCL1 LCN2. In turn, increase recruits chemokines causes further vivo improves early phase MetALD by preventing damage, steatosis, inflammation, immune cells recruitment.

Language: Английский

Citations

7
Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities DOI Creative Commons
Junshu Li, Wencheng Zhou, Huiling Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 24, 2024

Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical

Language: Английский

Citations

6
Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer DOI Creative Commons
Carlos Silvestre-Roig, Lydia Kalafati, Triantafyllos Chavakis

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: April 2, 2024

Language: Английский

Citations

4
Lipid mediators in neutrophil biology: inflammation, resolution and beyond DOI

Anita Ghodsi,

Andrés Hidalgo, Stephania Libreros

et al.

Current Opinion in Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Purpose of review Acute inflammation is the body's first defense in response to pathogens or injury. Failure efficiently resolve inflammatory insult can severely affect tissue homeostasis, leading chronic inflammation. Neutrophils play a pivotal role eradicating infectious pathogens, orchestrating initiation and resolution acute inflammation, maintaining physiological functions. The highly orchestrated biochemical process, partially modulated by novel class endogenous lipid mediators known as specialized pro-resolving (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR). Recent findings This focuses on recent advances understanding multifaceted functions SPMs, detailing roles expediting neutrophil apoptosis, promoting clearance macrophages, regulating excessive infiltration at sites, bone marrow deployment, also enhances phagocytosis repair mechanisms under both pathological conditions. We focus functions, differentiation, highlight open questions about SPMs’ heterogeneity. Summary mitigating hyperactivity within milieus, notably conditions such sepsis, cardiovascular disease, ischemic events, cancer. significant function highlights promising therapeutic agents management disorders.

Language: Английский

Citations

4
How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia DOI
Ananda S. Mirchandani, Manuel A. Sánchez-García, Sarah R. Walmsley

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Language: Английский

Citations

4
New insights on extramedullary granulopoiesis and neutrophil heterogeneity in the spleen and its importance in disease DOI

Rongxia Guo,

Xuemei Xie, Qian Ren

et al.

Journal of Leukocyte Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Neutrophils are traditionally viewed as uncomplicated exterminators that arrive quickly at sites of infection, kill pathogens, and then expire. However, recent studies employing modern transcriptomics coupled with novel imaging modalities have discovered neutrophils exhibit significant heterogeneity within organs complex functional roles ranging from tissue homeostasis to cancer chronic pathologies. This has revised the view simplistic butchers, there been a resurgent interest in neutrophils. The spleen was described granulopoietic organ more than 4 decades ago, indicate briefly retained before returning circulation after proliferation. Transcriptomic splenic heterogeneous distinct compared those blood. suggests unique hematopoietic niche exists microenvironment, i.e., capable programming spleen. During severe systemic inflammation an increased need neutrophils, can adapt by producing through emergency granulopoiesis. In this review, we describe structure microanatomy examine how cells microenvironment help regulate A focus is placed on exploring increase granulopoiesis meet host needs during infection inflammation. Emerging technologies such single-cell RNA sequencing, which provide valuable insight into neutrophil development heterogeneity, also discussed. Finally, tumors subvert natural pathway generate granulocytic suppressor promote tumor growth.

Language: Английский

Citations

4
Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies DOI Creative Commons
Xiaobin Fang, Chunheng Mo, Ling Zheng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Transfusion‐related acute lung injury (TRALI) is a potentially lethal complication of blood transfusions, characterized by the rapid onset pulmonary edema and hypoxemia within six hours post‐transfusion. As one primary causes transfusion‐related mortality, TRALI carries significant mortality rate 6–12%. However, effective treatment strategies for are currently lacking, underscoring urgent need comprehensive in‐depth understanding its pathogenesis. This review provides an updated detailed analysis current landscape TRALI, including clinical presentation, pathogenetic hypotheses, animal models, cellular mechanisms, signaling pathways, potential therapeutic targets. By highlighting critical roles these pathways therapies, this offers valuable insights to inform development preventative guide future research efforts aimed at addressing life‐threatening condition.

Language: Английский

Citations

0