Relationship between cognitive function and weight-adjusted waist index in people ≥ 60 years old in NHANES 2011–2014

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 9, 2024

Abstract Background Widespread attention has been given to the detrimental effects of obesity on cognitive function. However, there is no evidence connection between low performance and WWI (weight-adjusted waist index). This study looked into poor in senior Americans. Methods A cross-sectional research was carried out with information from NHANES 2011–2014. With multivariate linear regression models, pertinence function persons older than 60 years examined. The nonlinear link described using threshold effect analyses fitted smoothed curves. Interaction tests subgroup analysis were also conducted. Results had 2762 individuals all, subjects higher values at greater risk for In completely adjusted model, positively connected assessed by CERAD W-L (OR = 1.22, 95% CI 1.03–1.45, p 0.0239), AFT 1.30, 1.09–1.54, 0.0029), DSST 1.59, 1.30–1.94, < 0.0001). each positive correlation not significant. as determined a (log-likelihood ratio 0.05). Conclusion Among adults United States, may be related WWI.

Language: Английский

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Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of an Integrative and Sustainable Approach

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1725 - 1725

Published: May 31, 2024

The global population is on a trajectory of continuous growth, with estimates projecting an increase from 7.7 billion in 2019 to approximately 9.7 by 2050. Longevity also expected rise rapidly, advancements healthcare contributing increased life expectancies and the maximum lifespan. aging process accompanied different changes, often leading decline daily activities susceptibility disease. Age-related changes can cause cellular damage subsequent death. Oxidative stress inflammation play significant roles this molecular mitochondrial dysfunction. Active has been associated improved quality reduced risk morbidity premature mortality. In context, Mediterranean diet emerged as promising approach promoting healthy sustainability. phytochemical compounds within have linked lower developing cardiovascular disease, type 2 diabetes, obesity, cancer neurodegenerative diseases. findings peer-reviewed articles regarding use sustainable dietary pattern written Portuguese, Spanish or English were included narrative literature review. This pattern’s emphasis consumption fresh local food aligns both health environmental sustainability goals. work provides comprehensive review benefits its components highlights importance approach.

Language: Английский

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Digital forgotten people?: decomposing digital divide in urban China

Journal of Chinese Governance, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Oct. 3, 2024

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Trends in the prevalence of social isolation among middle and older adults in China from 2011 to 2018: the China Health and Retirement Longitudinal Study

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 1, 2024

Abstract Background Epidemiological studies have shown that social isolation, which is prevalent in older adults, associated with a range of adverse health outcomes, but the prevalence and trends regard to isolation remain ambiguous China. The aim this study was elucidate regarding among middle-aged adults China from 2011 2018 further identify risk factors. Methods A repeated cross-sectional study, data were derived panel sample four waves conducted May August nationally representative Health Retirement Longitudinal Study (CHARLS) using multistage probability sampling. Social ascertained by five item Steptoe Isolation Index. potential covariates demographic characteristics, lifestyle factors, status. Linear-by-linear association used assess over time under influence covariates. an age-period-cohort analysis explore trends, two-level (time, individual) generalized estimating equation models (GEE) linked multivariate binary logistic regression performed Results high moderate upward trend 2013 observed U-shaped across China, rates 38.09% (95% CI = 36.73–39.45) 2011, 33.66% (32.32–35.00) 2013, 39.13% (37.59–40.67) 2015, 39.95% (38.59–41.31) ( p < 0.001). increased age educational attainment. Females had higher than males. found be significantly lower pensioners non-pensioners between 38.9%, 34.9%, 38.5%, 44.08% about three times those who doid not use Internet 13.44%, 11.64%, 12.93%, 16.73% 2015 respectively. participants short (0–5 h) long sleep (9 or more hours), poor self-rated others. Older age, attainment, living rural region, lack medical insurance pension, internet factors 0.05). Conclusions We revealed increasing findings highlight urgent need for interventions reduce including improving quality skills. Disadvantaged groups terms economic status, status should focus such interventions, especially era COVID-19.

Language: Английский

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Marine peptides as potential anti-aging agents: Preparation, characterization, mechanisms of action, and future perspectives

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140413 - 140413

Published: July 14, 2024

Language: Английский

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Global, regional, and national burden of low back pain for adults aged 55 and older 1990–2021: an analysis for the global burden of disease study 2021

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 23, 2025

Language: Английский

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Arsenic Exposure Induces Neural Cells Senescence and Abnormal Lipid Droplet Accumulation Leading to Social Memory Impairment in Mice

Environmental Pollution, Journal Year: 2025, Volume and Issue: 368, P. 125779 - 125779

Published: Jan. 31, 2025

Language: Английский

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Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 87, P. 101935 - 101935

Published: April 14, 2023

Language: Английский

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The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Neurodegenerative diseases, particularly Alzheimer's disease and other dementias as well Parkinson's disease, are emerging profoundly significant challenges burdens to global health, a trend highlighted by the most recent Global Burden of Disease (GBD) 2021 studies. This growing impact is closely linked demographic shift toward an aging population potential long-term repercussions COVID-19 pandemic, both which have intensified prevalence severity these conditions. In this review, we explore several critical aspects complex issue, including increasing burden neurodegenerative unmet medical social needs within current care systems, unique amplified posed strategies for enhancing healthcare policy practice. We underscore urgent need cohesive, multidisciplinary approaches across medical, research, domains effectively address thereby improving quality life patients their caregivers.

Language: Английский

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Melatonin Mitigates Atrazine-Induced Renal Tubular Epithelial Cell Senescence by Promoting Parkin-Mediated Mitophagy

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

The accumulation of senescent cells in kidneys is considered to contribute age-related diseases and organismal aging. Mitochondria are a regulator cell senescence process. Atrazine as triazine herbicide poses threat renal health by disrupting mitochondrial homeostasis. Melatonin plays critical role maintaining present study aims explore the mechanism which melatonin alleviates atrazine-induced injury whether parkin-mediated mitophagy contributes mitigating senescence. found that level parkin was decreased after atrazine exposure negatively correlated with markers. treatment increased serum levels mitigates tubular epithelial Mechanistically, maintains integrity crista structure increasing contact site cristae organizing system, transcription factor A (TFAM), adenosine triphosphatase family AAA domain-containing protein 3A (ATAD3A), sorting assembly machinery 50 (Sam50) prevent DNA release subsequent activation cyclic guanosine 5′-monophosphate–adenosine 5′-monophosphate synthase pathway. Furthermore, activates Sirtuin 3–superoxide dismutase 2 axis eliminate reactive oxygen species kidney. More importantly, antisenescence largely determined parkin-dependent mitophagy. These results offer novel insights into measures against Parkin-mediated promising drug target for alleviating

Language: Английский

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