Advances and challenges in precision imaging

The Lancet Oncology, Journal Year: 2025, Volume and Issue: 26(1), P. e34 - e45

Published: Jan. 1, 2025

Language: Английский

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Molecular Stratification of Light-Chain Cardiac Amyloidosis With 18F-Florbetapir and 68Ga-FAPI-04 for Enhanced Prognostic Precision

JACC. Cardiovascular imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Optimizing Cancer Treatment: Exploring the Role of AI in Radioimmunotherapy

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 397 - 397

Published: Feb. 6, 2025

Radioimmunotherapy (RIT) is a novel cancer treatment that combines radiotherapy and immunotherapy to precisely target tumor antigens using monoclonal antibodies conjugated with radioactive isotopes. This approach offers personalized, systemic, durable treatment, making it effective in cancers resistant conventional therapies. Advances artificial intelligence (AI) present opportunities enhance RIT by improving precision, efficiency, personalization. AI plays critical role patient selection, planning, dosimetry, response assessment, while also contributing drug design classification. review explores the integration of into RIT, emphasizing its potential optimize entire process advance personalized care.

Language: Английский

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FAPI radiopharmaceuticals in nuclear oncology and theranostics of solid tumours: are we nearer to surrounding the hallmarks of cancer?

Annals of Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract [ 18 F]FDG PET/CT is the most widely used PET radiopharmaceutical in oncology, but it not exempt of diagnostic limitations. FAPI have emerged as a great tool management several different solid tumours which able to provide enough information. The aim this work was evaluate available evidence on and therapeutic applications with radiopharmaceuticals. We underwent non-systematic review focusing utility radiopharmaceuticals diagnosis treatment malignancies. present characteristics that can potentially overcome some known limitations F]FDG. high target-to-background ratio (TBR) many such oesophageal cancer, gastric pancreatic hepatic colorectal breast ovarian, cervical head neck cancer. Available suggests TBR improves sensitivity specificity compared F]FDG, especially for detection lymphadenopathies peritoneal metastases, may improve patient radiation planning. Moreover, important underline potential theranostic application

Language: Английский

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Unlocking the crucial role of cancer-associated fibroblasts in tumor metastasis: Mechanisms and therapeutic prospects

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Tumor metastasis represents a stepwise progression and stands as principal determinant of unfavorable prognoses among cancer patients. Consequently, an in-depth exploration its mechanisms holds paramount clinical significance. Cancer-associated fibroblasts (CAFs), constituting the most abundant stromal cell population within tumor microenvironment (TME), have garnered robust evidence support for their pivotal regulatory roles in metastasis. Review This review systematically explores CAFs at eight critical stages tumorigenic dissemination: 1) extracellular matrix (ECM) remodeling, 2) epithelial-mesenchymal transition (EMT), 3) angiogenesis, 4) metabolism, 5) perivascular migration, 6) immune escape, 7) dormancy, 8) premetastatic niche (PMN) formation. Additionally, we provide compendium extant strategies aimed targeting therapy. Key Scientific Concepts delineates structured framework interplay between while furnishing insights potential therapeutic developments. It contributes to deeper understanding TME, facilitating utilization CAF-targeting therapies anti-metastatic approaches.

Language: Английский

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Fibrotic phenotype of IgG4-related disease

The Lancet Rheumatology, Journal Year: 2024, Volume and Issue: 6(7), P. e469 - e480

Published: April 1, 2024

Language: Английский

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Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis

Arthritis Research & Therapy, Journal Year: 2024, Volume and Issue: 26(1)

Published: May 23, 2024

Abstract Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component inflamed synovium of patients with rheumatoid arthritis (RA). FLSs emerging as promising new therapeutic targets RA. However, fibroblasts perform many essential functions that required for sustaining tissue homeostasis. Direct targeting general fibroblast markers on is challenging because other tissues might be altered side effects such reduced wound healing or fibrosis can occur. To date, no FLS-specific targeted therapies have been applied clinical management With help high-throughput technologies scRNA-seq recent years, several specific pathogenic FLS subsets identified. Understanding characteristics these clusters mechanisms drive their differentiation provide insights into development novel FLS-targeting strategies Here, we discuss elucidated years potential FLSs.

Language: Английский

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Radiomolecular Theranostics With Fibroblast-Activation-Protein Inhibitors and Peptides

Seminars in Nuclear Medicine, Journal Year: 2024, Volume and Issue: 54(4), P. 537 - 556

Published: July 1, 2024

Language: Английский

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The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives

Endocrine Reviews, Journal Year: 2024, Volume and Issue: 45(4), P. 521 - 552

Published: Feb. 20, 2024

Abstract Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells adrenal medullary chromaffin tissues extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal options advanced metastatic cases have been limited. Hence, understanding role of immune system in PPGL tumorigenesis can provide essential knowledge development better therapeutic tumor management strategies, especially those with PPGLs. The first part this review outlines fundamental principles microenvironment, their cancer immunoediting, particularly emphasizing We focus on how unique pathophysiology PPGLs, such as high molecular, biochemical, imaging heterogeneity production several oncometabolites, creates a tumor-specific microenvironment immunologically “cold” tumors. Thereafter, we discuss recently published studies related to reclustering based signature. second discusses future perspectives management, including immunodiagnostic promising immunotherapeutic approaches converting into active or “hot” known immunotherapy response patient outcomes. Special emphasis placed potent immune-related strategies signatures that could be used reclassification, prognostication, these improve care prognosis. Furthermore, introduce currently available immunotherapies possible combinations other therapies an emerging targets hostile environments.

Language: Английский

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Diagnostic Potential of Supplemental Static and Dynamic⁶⁸Ga-FAPI-46 PET for Primary¹⁸F-FDG–Negative Pulmonary Lesions

Journal of Nuclear Medicine, Journal Year: 2024, Volume and Issue: 65(6), P. 872 - 879

Published: April 11, 2024

PET using ⁶⁸Ga-labeled fibroblast activation protein (FAP) inhibitors (FAPIs) holds high potential for diagnostic imaging of various malignancies, including lung cancer (LC). However, ¹⁸F-FDG is still the clinical gold standard LC imaging. Several subtypes LC, especially lepidic are frequently PET–negative, which markedly hampers assessment single pulmonary lesions suggestive LC. Here, we evaluated static and dynamic ⁶⁸Ga-FAPI-46 in ¹⁸F-FDG–negative 19 patients who underwent surgery or biopsy histologic diagnosis after For target validation, FAP expression was confirmed by immunohistochemistry. Methods: Hematoxylin eosin staining immunohistochemistry 24 tissue sections from local bank were performed analyzed visually. Clinically, addition to based on individual indications. Static data both examinations determining SUV_max, SUV_mean, tumor-to-background ratio (TBR) against blood pool, as well relative parameters (⁶⁸Ga-FAPI-46 relation to¹⁸F-FDG), histologically benign lesions. Time–activity curves (time peak, slope, k₁, k₂, k₃, k₄) extracted data. The sensitivity specificity all calculating receiver-operating-characteristic curves. Results: presence strongly FAP-positive cancer-associated fibroblasts showed elevated uptake, higher TBRs, ⁶⁸Ga-FAPI-46–to–¹⁸F-FDG ratios than did Dynamic analysis revealed differential time–activity lesions: initially increasing with a decent slope typical steadily decreasing curve indicated lesions, reflected significantly increased time peak smaller absolute values Relative regarding SUV_max TBR highest discrimination Conclusion:⁶⁸Ga-FAPI-46 powerful new tool may optimize patient stratification this setting.

Language: Английский

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