Susceptibility of SARS-CoV2 infection in children DOI Creative Commons
Nicola Cotugno, Donato Amodio, Danilo Buonsenso

et al.

European Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 182(11), P. 4851 - 4857

Published: Sept. 13, 2023

Abstract Coronavirus disease 2019 in children presents with distinct phenotype comparison to adults. Overall, the pediatric infection a generally milder clinical course of acute compared adults still faces several unknown aspects. Specifically, presence wide range inflammatory manifestations, including multisystem syndrome (MIS-C), myocarditis, and long COVID period after suggests particular susceptibility some upon severe respiratory coronavirus 2 (SARS-CoV-2) infection. Albeit peculiar complications such as covid are less frequent adults, research on relationship between syndromes SARS-CoV-2 is rapidly evolving. Conclusions : new studies findings continue emerge, providing further insights into underlying mechanisms potential therapeutic strategies. In present work, we revised current knowledge main factors accounting for variability over age group. What Known: • COVID19 overall showed during phase Children be susceptible post infectious neuroinflammation, COVID. New: Mechanisms were recently shown pertain host. A specific combination HLA was associated higher MIS-C children.

Language: Английский

Long COVID: major findings, mechanisms and recommendations DOI Open Access
Hannah Davis, Lisa McCorkell, Julia Moore Vogel

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(3), P. 133 - 146

Published: Jan. 13, 2023

Language: Английский

Citations

2875
Long COVID: pathophysiological factors and abnormalities of coagulation DOI Creative Commons
Simone Turner, Asad Khan, David Putrino

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 34(6), P. 321 - 344

Published: April 19, 2023

Acute COVID-19 infection is followed by prolonged symptoms in approximately one ten cases: known as Long COVID. The disease affects ~65 million individuals worldwide. Many pathophysiological processes appear to underlie COVID, including viral factors (persistence, reactivation, and bacteriophagic action of SARS CoV-2); host (chronic inflammation, metabolic endocrine dysregulation, immune autoimmunity); downstream impacts (tissue damage from the initial infection, tissue hypoxia, dysbiosis, autonomic nervous system dysfunction). These mechanisms culminate long-term persistence disorder characterized a thrombotic endothelialitis, endothelial hyperactivated platelets, fibrinaloid microclots. abnormalities blood vessels coagulation affect every organ represent unifying pathway for various

Language: Английский

Citations

154
Prevalence and risk factor for long COVID in children and adolescents: A meta-analysis and systematic review DOI Creative Commons
Yongbo Zheng, Na Zeng, Kai Yuan

et al.

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(5), P. 660 - 672

Published: March 7, 2023

Millions of COVID-19 pediatric survivors are facing the risk long COVID after recovery from acute COVID-19. The primary objective this study was to systematically review available literature and determine pooled prevalence of, factors for among survivors.

Language: Английский

Citations

109
Thromboinflammation in long COVID—the elusive key to postinfection sequelae? DOI Creative Commons
Leo Nicolai, Rainer Kaiser, Konstantin Stark

et al.

Journal of Thrombosis and Haemostasis, Journal Year: 2023, Volume and Issue: 21(8), P. 2020 - 2031

Published: May 11, 2023

Language: Английский

Citations

52
Long COVID in pediatrics—epidemiology, diagnosis, and management DOI Creative Commons
Nicole Toepfner, Folke Brinkmann,

Silvia Augustin

et al.

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(4), P. 1543 - 1553

Published: Jan. 27, 2024

Abstract This review summarizes current knowledge on post-acute sequelae of COVID-19 (PASC) and post-COVID-19 condition (PCC) in children adolescents. A literature was performed to synthesize information from clinical studies, expert opinions, guidelines. PASC also termed Long COVID — at any age comprise a plethora unspecific symptoms present later than 4 weeks after confirmed or probable infection with severe respiratory syndrome corona virus type 2 (SARS-CoV-2), without another medical explanation. PCC adolescents defined by the WHO as occurring within 3 months acute coronavirus disease 2019 (COVID-19), lasting least months, limiting daily activities. Pediatric mostly manifest mild courses majority cases remit few months. However, can last for more 1 year may result significant disability. Frequent include fatigue, exertion intolerance, anxiety. Some patients postural tachycardia (PoTS), small number fulfill criteria myalgic encephalomyelitis/chronic fatigue (ME/CFS). To date, no diagnostic marker has been established, differential diagnostics remains challenging. Therapeutic approaches appropriate self-management well palliation non-pharmaceutical pharmaceutical strategies. Conclusion : pediatrics heterogenous severity duration. stepped, interdisciplinary, individualized approach is essential management. Current health care structures have be adapted, research extended meet psychosocial needs young people similar conditions. What Known: • Post-acute (COVID-19) lead activity limitation reduced quality life. belongs large group syndromes (PAIS). Specific biomarkers causal treatment options are not yet available. New: In February 2023, case definition post provided World Health Organization (WHO), indicating duration Interdisciplinary collaborations necessary established worldwide offer harmonized, multimodal diagnosis management PASC/PCC

Language: Английский

Citations

21
Chronic Lung Injury after COVID-19 Pneumonia: Clinical, Radiologic, and Histopathologic Perspectives DOI
Min Jae, Joshua J. Solomon, Jong Eun Lee

et al.

Radiology, Journal Year: 2024, Volume and Issue: 310(1)

Published: Jan. 1, 2024

With the COVID-19 pandemic having lasted more than 3 years, concerns are growing about prolonged symptoms and respiratory complications in survivors, collectively termed post-COVID-19 condition (PCC). Up to 50% of patients have residual physiologic impairment, particularly dyspnea reduced diffusion capacity. Studies also shown that 24%-54% hospitalized during 1st year exhibit radiologic abnormalities, such as ground-glass opacity, reticular bronchial dilatation, air trapping, when imaged 1 after infection. In with persistent but normal results at chest CT, dual-energy contrast-enhanced xenon 129 MRI, low-field-strength MRI were reported show abnormal ventilation and/or perfusion, suggesting some lung injury may not be detectable standard CT. Histologic patterns disease include fibrosis, organizing pneumonia, vascular abnormality, indicating different pathologic mechanisms contribute PCC. Therefore, a comprehensive imaging approach is necessary evaluate diagnose symptoms. This review will focus on long-term findings clinical abnormalities describe histopathologic perspectives. It addresses advanced techniques deep learning approaches can applied survivors. field remains an active area research, further follow-up studies warranted for better understanding chronic stage developing multidisciplinary patient management.

Language: Английский

Citations

19
Diagnosis and management of post-COVID (Long COVID) in children: a moving target DOI Creative Commons
Rosa Morello,

Laura Martino,

Danilo Buonsenso

et al.

Current Opinion in Pediatrics, Journal Year: 2023, Volume and Issue: 35(2), P. 184 - 192

Published: Jan. 20, 2023

Purpose of review This describes recent findings about post-COVID condition (PCC, or Long COVID) in children, including current knowledge its epidemiology, clinical presentation, pathogenesis and care. Recent There is no internationally agreed definition PCC, although now most researchers agree that it a complex symptomatology persisting for at least 3 months after COVID-19, without an alternative diagnosis. are several uncertainties paediatric PCC. So far, available literature suggest 1–3% recognized children with Severe Acute Respiratory Syndrome COronaVirus 2 (SARS-CoV-2) infection may develop Its unknown, there increasing evidence possible abnormalities the immune responses, cellular metabolism intestinal microbiota, along chronic endothelitis. Summary Management PCC require multidisciplinary approach, goal offering best care to support diagnostics, research, mental health access research projects.

Language: Английский

Citations

35
Depression and anxiety before and at the beginning of the COVID-19 pandemic and incident persistent symptoms: a prospective population-based cohort study DOI
Joane Matta, Olivier Robineau, Emmanuel Wiernik

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(10), P. 4261 - 4271

Published: July 19, 2023

Language: Английский

Citations

31
Cardiopulmonary Exercise Testing in Children With Long COVID: A Case-controlled Study DOI Creative Commons

Fabiana Baldi,

Cristina De Rose, Francesco Mariani

et al.

The Pediatric Infectious Disease Journal, Journal Year: 2024, Volume and Issue: 43(8), P. 795 - 802

Published: May 7, 2024

Background: Cardiopulmonary exercise testing (CPET) is a noninvasive and nonexpensive diagnostic tool, that provides comprehensive evaluation of the pulmonary, cardiovascular, skeletal muscle systems’ integrated reactions to exercise. CPET has been extensively used in adults with Long COVID (LC), while evidence about its role children this condition scarce. Methods: Prospective, case-controlled observational study. Children LC control group healthy underwent CPET. findings were compared within 2 groups, groups according main clusters persisting symptoms. Results: Sixty-one 29 controls included. Overall, 90.2% patients (55 61) had pathologic test vs 10.3% (3/29) control. presented statistically significant higher probability having abnormal values peak VO2 ( P = 0.001), AT% pred <0.001), VO2/HR % 0.03), work slope 0.002), VE/VCO2 0.01). The mean was 30.17 (±6.85) 34.37 (±6.55) 0.007). Conclusions: Compared controls, have objective impaired functional capacity (expressed by low peak), signs deconditioning cardiogenic inefficiency when assessed As such, should be routinely clinical practice objectify phenotype limitations LC, follow-up them.

Language: Английский

Citations

10
Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies DOI Creative Commons
Sanaz A. Behnood, Fiona Newlands, Lauren L. O’Mahoney

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(12), P. e0293600 - e0293600

Published: Dec. 28, 2023

Background Research on the long-term impact COVID-19 in children and young people (CYP) has been published at pace. We aimed to update refine an earlier systematic review meta-analysis assess current evidence for Post-COVID-19 Condition CYP. Methods Studies from previous were combined with studies a search July 2021 November 2022 (registration PROSPERO CRD42021233153). Eligible included CYP aged ≤19 years confirmed or probable SARS-CoV-2 infection symptoms persisting least 12 weeks. Findings 55 (n = 1,139,299 participants) included. Over two-hundred associated Post Condition. Gastrointestinal problems, headaches, cough fever among most prevalent rates of 50.2%, 35.6%, 34.7% 25.8% respectively. Twenty-one 11 suitable meta-analysis. There significantly higher pooled estimates proportions altered / loss smell taste, dyspnoea, fatigue, myalgia infection. Heterogeneity was high suggesting substantial variation amongst studies. Conclusions Many continue experience after Efforts aid early identification intervention those need is warranted consequences call follow-up.

Language: Английский

Citations

23