From Echoes to Disruption: US from Diagnostic Imaging to Precision Therapeutic Modality

Radiology, Journal Year: 2024, Volume and Issue: 312(3)

Published: Sept. 1, 2024

Language: Английский

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Oncologic Outcomes after Percutaneous Ablation for Colorectal Liver Metastases: An Updated Comprehensive Review

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1536 - 1536

Published: Sept. 20, 2024

Colorectal cancer is a major cause of cancer-related mortality, with liver metastases occurring in over third patients, and correlated poor prognosis. Despite surgical resection being the primary treatment option, only about 20% patients qualify for surgery. Current guidelines recommend thermal ablation either alone or combined surgery to treat limited hepatic metastases, provided that all visible disease can be effectively eradicated. Several modalities, including radiofrequency ablation, microwave cryoablation, irreversible electroporation histotripsy, are part percutaneous armamentarium. Thermal radiofrequency, offer local tumor control rates comparable selected tumors ablated margins. This review aims encapsulate current clinical evidence regarding efficacy oncologic outcomes after colorectal metastatic disease.

Language: Английский

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Abscopal Effect with Liver-Directed Therapy: A Review of the Current Literature and Future Directions

Livers, Journal Year: 2024, Volume and Issue: 4(4), P. 601 - 614

Published: Nov. 22, 2024

The liver is a common site for metastatic disease. In select patients with isolated metastases, surgical resection improves survival and may be potentially curative in favorable “tumor biology”. However, when not feasible, liver-directed therapies (LDTs) can also improve outcomes, including survival, the appropriate clinical situations. LDTs, hepatic artery infusion, radioembolization, radiation, ablation techniques, such as thermal histotripsy, offer local control potential systemic effects, abscopal effect. effect occurs nontargeted, nontreated tumors regress following localized therapy to other tumors. Preclinical studies suggest that antigen-induced upregulation of key immune regulators plays central role this process. Unfortunately, reports LDT are exceedingly rare. noninvasive, nonionizing, nonthermal technique, induce an more frequently robustly than LDTs. Histotripsy enhances tumor immunogenicity through precise acoustic cavitation better preserves tissue architecture while increasing antigen release, resulting robust response. Ongoing trials investigating these immunogenic mechanisms ability generate reliably adjuncts checkpoint inhibitors. This work has significant implications regarding management metastasis.

Language: Английский

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How could histotripsy change cancer immunotherapy?

Immunotherapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 3

Published: Dec. 18, 2024

Language: Английский

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Role of locoregional therapy including liver transplantation in liver-only metastatic colorectal cancer: a review Paper

Expert Review of Anticancer Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Dec. 24, 2024

Resection of primary tumor and liver metastases is the gold standard for colorectal cancer with liver-only (CRLM). Although treatment options have expanded to enable conversion unresectable resectable CRLM, about 40% patients will definitively disease. Major advances in surgical techniques, immunosuppressive protocols patient selection criteria transplantation resulted improved outcomes.

Language: Английский

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Advanced approaches to loco-regional and surgical management for hepatocellular carcinoma

Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 15(6), P. 2739 - 2742

Published: Dec. 1, 2024

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