Performance of Magnetic Resonance Imaging and Ultrasound for Identifying the Different Degrees of Hepatic Steatosis: A Systematic Review and Meta-analysis

Academic Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

MRI proton density fat fraction (MRI-PDFF), controlled attenuation parameters (CAP), and coefficients (AC) are capable of steatosis characterization may be useful as noninvasive alternatives for diagnosing hepatic steatosis. This meta-analysis aimed to evaluate the performance MRI-PDFF, CAP, AC in grading steatosis, using histology reference standard. We conducted a comprehensive search PubMed, Cochrane Library, Embase, Web Science databases until June 2024. The quality eligible studies was assessed. Pooled sensitivity, specificity, area under receiver operating characteristic (AUC) curves were calculated bivariate random-effects model. Meta-regression analysis, subgroup Deeks' test performed explore heterogeneity assess publication bias. included 38 with 5056 patients metabolic dysfunction-associated steatotic liver disease. AUC values ≥S1, ≥S2, ≥S3 0.99, 0.89, 0.90 0.95, 0.84, 0.77 0.97, 0.90, 0.89 AC, respectively. CAP demonstrated lower accuracy detecting grades ≥S2 compared MRI-PDFF (0.89 vs. p<0.001; 0.77, p<0.001) (0.90 p<0.001). Subgroup analyses revealed that exhibited superior diagnostic among individuals Asia, body mass index ≤30 kg/m2, age <51 years. A direct comparison showed greater moderate severe similar AC. For should incorporated into routine ultrasound screening.

Language: Английский

---

Application of additive manufacturing for the adaptive design of ultrasound phantoms

Frontiers in Physics, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Introduction The image formation process of conventional pulse-echo Ultrasound mainly uses the backscattered amplitude and assumes constant attenuation speed sound in penetrated media. Thus, many commercially available ultrasound imaging phantoms use only a limited choice materials with simple geometric shapes. Part today’s research is to gain more information on acoustic properties object imaged. These advanced reconstruction procedures require complicated phantom designs that contain different precisely designable for validation quality assurance (QA). Methods To fabricate such phantoms, we produced molds casting using additive manufacturing. Phantom used were based agar polyvinyl alcohol. adapt glycerol was added mixtures. As diffuses out material, polluting surrounding water, designed watertight sample holder. effect freeze-thaw cycles (FTCs) alcohol (PVA)-based also investigated. Speed determined both materials, Shore hardness measured PVA-based phantoms. Results PVA increased by up 79% initial value increasing number cycles, but showed saturation after 5 FTCs. However, FTCs had small attenuation, as slightly from 1,530.14 m/s 1,558.53 m/s, (1.86%) exhibited an increase 6.75%. In contrast, differences around 100 (from 1,662.27 m/s), well agar-based 1,501.74 1,609.36 m/s) could be achieved adding glycerol, making these appropriate candidates design fabrication US defined sections details attenuation. holder influence 0.63% sound. Discussion 3D printed led improved manufacturing free shape A prevent contamination water no significant

Language: Английский

---

MR and Ultrasound for Liver Fat Assessment in Children: Techniques and Supporting Evidence

Journal of Magnetic Resonance Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Hepatic steatosis is a common imaging finding that can be sign of chronic liver disease, most often associated with metabolic dysfunction-associated steatotic disease (MASLD). Imaging techniques for evaluating range from basic qualitative assessments to advanced and highly accurate quantitative metrics. Among these, MRI-based proton density fat fraction (PDFF) widely regarded as reliable precise biomarker quantifying steatosis. Additionally, multiple ultrasound platforms now offer hepatic These methods include attenuation coefficient, speed sound, backscatter, or other multiparametric approaches such ultrasound-derived (UDFF) which combines backscatter quantification. Newer upcoming acoustic structure quantification (ASQ) tissue scatter distribution (TSI). Therefore, ultrasound-based measurements could potentially serve an effective screening tool in certain clinical settings, suspected MASLD. In this review, we describe how, why, when use MRI- assessing children. We discuss practical strategies adapting optimizing these pediatric considering indications, patient preparation, equipment needs, acquisition techniques, potential pitfalls, confounding factors. guidance provided interpretation reporting, along illustrative case examples. Evidence Level: N/A Technical Efficacy: Stage 5.

Language: Английский

---

Attenuation Coefficient for Hepatic Steatosis Using a Single Ultrasound System: Associations of Measurement Parameters With Interoperator Agreement and Diagnostic Performance

American Journal of Roentgenology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Background: Clinical adoption of ultrasound attenuation coefficient (AC) measurements has been hindered by lack uniform measurement protocol and a range factors that may cause variability. Objective: To evaluate associations ROI depth, size, confidence map threshold with interobserver agreement diagnostic performance AC in detecting grading hepatic steatosis using MRI proton-density fat fraction (PDFF) as the reference standard. Methods: This prospective study enrolled adults known or at risk for from October 2023 to August 2024. One two operators obtained videos acquisitions single unit. Both independently reviewed all placed circular ROIs obtain 24 possible combinations four depths (2.0, 2.5, 3.0, 4.0 cm liver capsule outer edge), three sizes (3.0, 3.5, cm), thresholds (20% 40%). Participants underwent PDFF reference. Results: The analysis included 101 participants (mean age, 54.5±12.1 years; 62 female, 39 male). Interoperator was excellent (intraclass correlation coefficient: 0.92-0.98). showed strongest correlations (Spearman rho, 0.81 0.80 1 2, respectively) depth cm. optimal combination considering AUC across grades cm, size 40%. had grade >0, >1, >2 operator 0.93, 0.88, 0.81, respectively, 2 0.92, 0.86, respectively. However, accuracy (grade >0) highest 3.0 40% (operator 1, 90.1%; 82.2%). Conclusion: interoperator parameter combinations. Correlations were Combinations yielding identified. Impact: These results will help determine standardized measurements, facilitating clinical quantification.

Language: Английский

---

US Attenuation Coefficient for Liver Fat Quantification: A Need for Standardization

Radiology, Journal Year: 2024, Volume and Issue: 313(1)

Published: Oct. 1, 2024

Language: Английский

---