Acute Myocardial Infarction in COVID-19 Patients—A Review of Literature Data and Two-Case Report Series DOI Open Access

Luiza Nechita,

Elena Niculeț, Liliana Baroiu

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2936 - 2936

Published: May 16, 2024

Background/Objectives: The newly emergent COVID-19 pandemic involved primarily the respiratory system and had also major cardiovascular (CVS) implications, revealed by acute myocardial infarction (AMI), arrhythmias, injury, thromboembolism. CVS involvement is done through main mechanisms-direct indirect heart muscle with high mortality rates, worse short-term outcomes, severe complications. AMI echo of injury (revealed increases in CK, CK-MB, troponin serum markers-which are taken into consideration as possible risk stratification markers). When studying physicians can make use imaging studies, such cardiac MRI, transthoracic (or transesophageal) echocardiography, coronary angiography, computed tomography, nuclear (which have been used cases where angiography was not possible), or even endomyocardial biopsy always available feasible). Two-case-series presentations: We present two positive male patients who were admitted Clinical Department Cardiology "Sfântul Apostol Andrei" Emergency Hospital Galați (Romania), presented distress symptoms diagnosed ST elevation AMI. 82 57 years old, respectively, moderate forms COVID-19, anteroseptal left ventricular extensive anterior transmural (with fibrillation at presentation), respectively. first patient a non-smoker non-drinker no associated comorbidities, later discharged, while second one died due to Conclusions: From this two-case series, we extract following: old age alone significant factor for adverse outcomes COVID-19-related events, that cumulative effects several patient-associated factors (be it either and/or injury) will most probably lead poor prognosis (death). At same time, enzymes, dynamic ECG changes, along developed echocardiographic modifications indicators regardless presence right dysfunction (due pulmonary hypertension).

Language: Английский

Cardiovascular magnetic resonance imaging and clinical follow-up in patients with clinically suspected myocarditis after COVID-19 vaccination DOI Creative Commons
Norain Talib, Matteo Fronza, Constantin Marschner

et al.

Journal of Cardiovascular Magnetic Resonance, Journal Year: 2024, Volume and Issue: 26(1), P. 101036 - 101036

Published: Jan. 1, 2024

The purpose of this study was to evaluate cardiovascular magnetic resonance (CMR) findings and their relationship longer-term clinical outcomes in patients with suspected myocarditis following COVID-19 vaccination. Consecutive adult who underwent clinically indicated CMR for evaluation mRNA-based vaccination at a single center between 2021-2022 were retrospectively evaluated. Patients classified based on the revised Lake Louise criteria T1-based abnormalities (late gadolinium enhancement or high T1 values) T2-based (regional T2-hyperintensity T2 values). Eighty-nine included (64% male, mean age 34±13 years, 38% mRNA-1273 62% BNT162b2). On baseline CMR, 42 (47%) had least one abnormality; 25 (28%) met both T1- T2-criteria; 17 (19%) T1-criteria but not 47 (53%) did meet either. interval shorter those T2-criteria (28 days, IQR 8-69) compared only (110 66-255, p<0.001) either (120 80-252, p<0.001). In subset 21 follow-up myocardial edema resolved LVEF normalized all median imaging 214 days (IQR 132-304). However, minimal LGE persisted 10 (48%). At 232 156-405, n=60), there no adverse cardiac events. mild symptoms 7 (12%). cohort vaccination, 47% abnormality CMR. Detection associated timing after There 48% follow-up.

Language: Английский

Citations

6
MRI of cardiac involvement in COVID-19 DOI Creative Commons
Moezedin Javad Rafiee, Matthias G. Friedrich

British Journal of Radiology, Journal Year: 2024, Volume and Issue: 97(1160), P. 1367 - 1377

Published: April 24, 2024

Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a diverse pattern of myocardial injuries, including myocarditis, which is linked adverse outcomes in patients. Research indicates that injury associated with higher mortality hospitalized severe patients (75.8% vs 9.7%). Cardiovascular Magnetic Resonance (CMR) emerged as crucial tool diagnosing both ischaemic and non-ischaemic providing detailed insights into impact on tissue function. This review synthesizes existing studies histopathological findings CMR imaging patterns injuries revealed complex cardiac damage these patients, inflammation, oedema, fibrosis, injury, due coronary microthrombi. also highlights role LLC criteria diagnosis COVID-related myocarditis importance detecting complications specific groups, such children, manifesting multisystem inflammatory syndrome children (MIS-C) athletes, well post-COVID-19 infection or following vaccination. By summarizing highlighting ongoing research, this contributes deeper understanding impacts COVID-19. It emphasizes effectiveness assessing broad spectrum thereby enhancing management prognosis related complications.

Language: Английский

Citations

4
The Ambivalence of Post COVID-19 Vaccination Responses in Humans DOI Creative Commons
Radha Gopalaswamy, Vivekanandhan Aravindhan, Selvakumar Subbian

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1320 - 1320

Published: Oct. 17, 2024

The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has prompted a massive global vaccination campaign, leading to the rapid development and deployment of several vaccines. Various COVID-19 vaccines are under different phases clinical trials include whole virus or its parts like DNA, mRNA, protein subunits administered directly through vectors. Beginning in 2020, few mRNA (Pfizer-BioNTech BNT162b2 Moderna mRNA-1273) adenovirus-based (AstraZeneca ChAdOx1-S Janssen Ad26.COV2.S) were recommended WHO for emergency use before completion phase 3 4 trials. These mostly two three doses at defined frequency between doses. While these vaccines, mainly based on viral nucleic acids conferred protection against progression SARS-CoV-2 infection into COVID-19, prevented death due disease, their also been accompanied plethora side effects. Common effects localized reactions such as pain injection site, well systemic fever, fatigue, headache. symptoms generally mild moderate resolve within days. However, rare but more serious have reported, including allergic anaphylaxis and, some cases, myocarditis pericarditis, particularly younger males. Ongoing surveillance research efforts continue refine understanding adverse effects, providing critical insights risk-benefit profile Nonetheless, overall safety supports continued combating with regulatory agencies health organizations emphasizing importance preventing COVID-19's outcomes. In this review, we describe types summarize various autoimmune inflammatory response(s) manifesting predominantly cardiac, hematological, neurological, psychological dysfunctions. incidence, presentation, risk factors, diagnosis, management possible mechanisms contributing discussed. review highlights potential ambivalence human response post-COVID-19 necessitates need mitigate

Language: Английский

Citations

3
Acute Myocardial Infarction in COVID-19 Patients—A Review of Literature Data and Two-Case Report Series DOI Open Access

Luiza Nechita,

Elena Niculeț, Liliana Baroiu

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2936 - 2936

Published: May 16, 2024

Background/Objectives: The newly emergent COVID-19 pandemic involved primarily the respiratory system and had also major cardiovascular (CVS) implications, revealed by acute myocardial infarction (AMI), arrhythmias, injury, thromboembolism. CVS involvement is done through main mechanisms-direct indirect heart muscle with high mortality rates, worse short-term outcomes, severe complications. AMI echo of injury (revealed increases in CK, CK-MB, troponin serum markers-which are taken into consideration as possible risk stratification markers). When studying physicians can make use imaging studies, such cardiac MRI, transthoracic (or transesophageal) echocardiography, coronary angiography, computed tomography, nuclear (which have been used cases where angiography was not possible), or even endomyocardial biopsy always available feasible). Two-case-series presentations: We present two positive male patients who were admitted Clinical Department Cardiology "Sfântul Apostol Andrei" Emergency Hospital Galați (Romania), presented distress symptoms diagnosed ST elevation AMI. 82 57 years old, respectively, moderate forms COVID-19, anteroseptal left ventricular extensive anterior transmural (with fibrillation at presentation), respectively. first patient a non-smoker non-drinker no associated comorbidities, later discharged, while second one died due to Conclusions: From this two-case series, we extract following: old age alone significant factor for adverse outcomes COVID-19-related events, that cumulative effects several patient-associated factors (be it either and/or injury) will most probably lead poor prognosis (death). At same time, enzymes, dynamic ECG changes, along developed echocardiographic modifications indicators regardless presence right dysfunction (due pulmonary hypertension).

Language: Английский

Citations

2