Ultrasensitive turn-off fluorescent sensor for estimation of the new influenza antiviral prodrug baloxavir marboxil in its pharmaceutical formulation
Royal Society Open Science,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Jan. 1, 2025
Carbon
quantum
dots
(CQDs)
are
a
recently
developed
class
of
fluorescent
nanoparticles
made
from
carbon.
Co-doping
with
heteroatoms
such
as
nitrogen
and
sulfur
improved
the
properties
generated
high
yield.
In
proposed
study,
we
utilized
simple,
cost-effective,
single-stage
hydrothermal
approach
to
produce
extreme
photoluminescence
co-doped,
sulfur,
CQDs
(N,S-CODs).
Thiosemicarbazide
was
used
source,
while
citric
acid
carbon
source
probes.
The
prepared
N,S-CQDs
were
subjected
extensive
characterization.
yielded
strong
fluorescence
emission
at
λ
em
430.0
nm
after
excitation
ex
360.0
nm,
relatively
yield
41.3%
utilizing
quinine
sulfate
reference
compound.
These
applied
nanosensors
for
ultrasensitive
spectrofluorimetric
determination
baloxavir
marboxil
(BXM)
directly
without
pre-derivatization
first
time.
BXM
effectively
quenches
native
N,S-CQDs.
Considering
optimal
conditions,
intensity
reduction
exhibited
‘turn-off’
response
concentrations
10.0–100.0
ng
ml
−1
,
detection
limits
1.88
quantitation
5.69
respectively.
method
determined
successfully
in
its
tablet
dosage
form
further
expanded
confirm
content
uniformity
units
agreement
USP
guidelines.
Language: Английский
Solid contact microfabricated electrode for electrochemical determination of tolterodine tartrate based a transducer layer ZnO@α-Fe2O3 nanocomposite in spiked urine and wastewater samples
Microchemical Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113097 - 113097
Published: Feb. 1, 2025
Language: Английский