Review—Machine Learning-Driven Advances in Electrochemical Sensing: A Horizon Scan

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(9), P. 097503 - 097503

Published: Aug. 5, 2024

The burgeoning intersection of machine learning (ML) with electrochemical sensing heralds a transformative era in analytical science, pushing the boundaries what’s possible detecting and quantifying chemical substances unprecedented precision efficiency. This convergence has accelerated number discoveries, improving sensors’ sensitivity, selectivity, ability to comprehend complicated data streams real-time. Such advancements are crucial across various applications, from monitoring health biomarkers environmental pollutants ensuring industrial safety. Yet, this integration is not without its challenges; it necessitates navigating intricate ethical considerations around use, robust privacy measures, developing specialized software tools that balance accessibility security. As field progresses, addressing these challenges head-on essential for harnessing full potential ML-enhanced sensing. review briefly explores dimensions, spotlighting significant technological strides, landscape, dynamic interplay between open-source proprietary solutions while also casting forward gaze at promising future directions interdisciplinary venture.

Language: Английский

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Eco-Friendly Mycogenic Synthesis of Iron Oxide Nanoparticles Using Volvariella volvacea and Unveiling its Potential as Antibiofilm and Anticancer Agents

ECS Journal of Solid State Science and Technology, Journal Year: 2024, Volume and Issue: 13(8), P. 087003 - 087003

Published: July 22, 2024

This research explores the eco-friendly creation of functional, biocompatible nanomaterials through green chemistry, utilizing natural extracts over chemicals to produce metal and oxide nanoparticles. The study focuses on iron nanoparticles synthesized with Volvariella volvacea (GIONP) evaluates their physical, chemical, biological traits, including anticancer capabilities, against traditionally made IONPs (CIONP). GIONPs, confirmed by UV-visible spectroscopy dynamic light scattering, showed enhanced stability consistent size distribution. They also demonstrated smaller sizes via -Field Emission scanning electron microscopy analysis, X-ray diffraction Fourier transform infrared studies verified crystalline structure organic functional groups. Notably, GIONPs exhibited strong antioxidant properties, low toxicity blood cells, promising for intravenous use, greater antimicrobial antibiofilm activities various bacterial strains than CIONPs. revealed that both CIONPs exhibit a similar degree towards MDA-MB 231 cancer cells. internalization within these cells was Prussian blue assay further supported concentration-dependent increase in intracellular levels post-treatment. These findings underscore successful formulation are not only but capped bioactive compounds, highlighting applications field biomedicine.

Language: Английский

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The role of 3D printing in advancing biotechnology and bioengineering: A review

Published: April 24, 2025

Three-dimensional (3D) printing, a subset of additive manufacturing technologies, has attracted significant attention from researchers for both laboratory-based and on-site prototyping since its widespread adoption. Its adaptability versatility have made it an essential tool across various disciplines, particularly in biotechnology bioengineering. While conventional methods can offer precise material control compatibility with biological fluids, they often pose challenges, such as high costs the requirement large, complex setups. These constraints limit their accessibility experimental needs However, 3D printers, ability to process wide range materials, proven be remarkably effective resolving these challenges. Their capability create custom parts structures while maintaining biomaterials fluids opened new possibilities not only tissue engineering, drug development, biomedical device fabrication but also broader fields biotechnology, biochemistry, related sciences. When examining basic concept development timeline becomes clear that emerging trends artificial intelligence, robotics, digitalization are expected further accelerate integration into real-world applications. ongoing advancements likely benefit laboratories production centers involved by speeding up experiments, paving way rapid testing, making biofabrication processes more accessible automated, including areas like engineering personalized medicine.

Language: Английский

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To determine the role of TRIT1 in the diagnosis, prognosis and immunoinvasion of liver hepatocellular carcinoma

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 5, 2025

Background TRIT1 is identified as a potential tumor suppressor gene that may be involved in development. Existing research indicates significant the development of certain cancers. However, its specific role liver cancer remains elusive. Methods Expression profiles and clinical data hepatocellular carcinoma (LIHC) patients were retrieved from The Cancer Genome Atlas (TCGA) database. levels between LIHC tissues normal compared using Wilcoxon rank-sum test. Additionally, expression further examined via reverse transcription quantitative polymerase chain reaction (RT-qPCR). Functional enrichment analysis was performed to elucidate biological pathways associated with TRIT1. Immune cell infiltration patterns evaluated single-sample set (ssGSEA). methylation status analyzed UALCAN MethSurv databases. Cox regression Kaplan-Meier (KM) methods employed determine prognostic value To create practical tool for predicting overall survival over time, nomogram constructed. Results revealed significantly higher tissues. Furthermore, elevated found subtypes LIHC, including T3 stage III. Importantly, overexpression negative marker patients. hypermethylation poor prognosis. Moreover, this study demonstrated high correlated reduced cytotoxic immune cells microenvironment, B cells, plasmacytoid dendritic (pDCs). Conclusions This provides first evidence presence can serve reliable diagnosis prognostication carcinoma. emerges critical indicator invasion system, holding implications targeted therapies

Language: Английский

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Engineering Signal Interfaces for Enhanced Electrochemical Biosensing

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118310 - 118310

Published: May 1, 2025

Language: Английский

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3D Surface-Enhanced Raman Scattering Substrate Based on an Array of Self-Assembled Au@SiO₂ Microspheres

ECS Journal of Solid State Science and Technology, Journal Year: 2024, Volume and Issue: 13(7), P. 077013 - 077013

Published: July 1, 2024

A quasi-periodic array of 3D gold-nanoparticle-capped SiO 2 microspheres (Au@SiO ) was designed and prepared with a facile approach to enhance the Raman signal intensity adsorbed biomolecules. Through adjusting thickness annealing Au thin films initially deposited on arrays self-assembled microspheres, we were able control diameter nanoparticles their interparticle spacing produce two types plasmonic near-field hot spots, locating at gaps such densely arranged individual in gap regions neighboring respectively. Such double enhancement mechanism leads surface-enhanced scattering (SERS) factor up 3 × 10 6 for Rhodamine 6G molecules. The SERS highly uniform relative standard deviation 4.5%. This substrate has significant potential various applications field detection analytes wearable biosensing.

Language: Английский

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Review—Advances on Covalent Organic-Frameworks as Innovative Materials for Designing Electrochemical Sensors

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(7), P. 077521 - 077521

Published: July 1, 2024

Covalent organic frameworks (COFs) have emerged as a ground-breaking class of porous crystalline materials, offering unparalleled potential in the realm electrochemistry. Their exceptional properties, including high surface area, tunable porosity, chemical stability, and redox properties make COFs uniquely suited for advanced electrochemical sensors. This review delves into main aspects COFs, exploring their synthesis methods, intrinsic pivotal role enhancing sensor performance. Moreover, latest advancements COF-based sensors will be discussed, highlighting versatile applications detecting wide array analytes such biomolecules, metal ions, pollutants. By summarizing significant challenges promising opportunities this field, we underscore transformative electroanalytical chemistry seamless integration next-generation electronic devices.

Language: Английский

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RGO-g-C₃N₄-Co₃O₄ Composite Modified Platinum Electrode for Electrochemical Detection of Dopamine

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(11), P. 117507 - 117507

Published: Oct. 30, 2024

A novel RGO-g-C 3 N 4 -Co O composite modified platinum electrode with significant sensing performance for dopamine was fabricated. Herein, hybrid nanostructure could boost the electrocatalytic of nanoparticles by avoiding clustering nanoparticles. These spinel-based composites are stable and affordable materials. Electrochemical impedance spectroscopy revealed enhanced electron transfer at electrode, as evidenced lowest charge resistance (Rct) RGO-g-C₃N₄-Co₃O₄/Pt electrode. An increased electroactive surface area compared to bare other Pt electrodes obtained. Several experimental parameters were optimized maximize sensitivity, including choice supporting electrolyte pH. Cyclic voltammetry conducted varying scan rates confirmed that oxidation followed a diffusion-controlled process. The exhibits outstanding activity, detection limit low 8.10 × 10 −7 M, demonstrating wide linear range between 2.00 −6 M −4 M. Selectivity tests indicated sensor reliably detect in presence common interfering substances such NaCl, KCl, glucose urea, ascorbic acid, uric acid L-dopa. This sensitivity selectivity validated both synthetic blood urine samples, providing electrode’s potential real-world applications diagnosis neurodegenerative diseases.

Language: Английский

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Review—Trends on the Development of Non-Enzymatic Electrochemical Sensors Modified with Molecularly Imprinted Polymers for the Quantification of Glucose

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(7), P. 077506 - 077506

Published: June 28, 2024

Glucose is the principal source of energy for humans and its quantification in physiological samples can diagnose or prevent diseases. Commonly, glucose determination based on spectrophotometric-enzymatic techniques, but since at least a decade ago, electroanalytical strategies have emerged as promising alternatives providing accuracy precision biomolecules. This review focuses development non-enzymatic methodologies modified electrochemical sensors with molecularly imprinted polymers (MIPs) detection (blood, saliva, urine). The trends construction base MIP combine materials such carbonaceous materials, metal nanoparticles, improving their electrocatalytic properties analytical parameters electro-analytical developed. Glassy carbon electrodes, paste screen-printed electrodes are main transductors oxidation glucose, maximum anodic peak current taken to signal. In all reported sensors, presence improved compared bare working electrode. results demonstrated that this approach represents viable alternative fast confident analysis molecule overcoming drawbacks presented by enzymatic sensors.

Language: Английский

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Synthesis, Studies of Inorganic Class of Mohrite (MOH) Crystals for Electrical, Electronic, Photonic, Phase Matching and Sensor Utilities by Theory and Practice

ECS Journal of Solid State Science and Technology, Journal Year: 2024, Volume and Issue: 13(7), P. 077009 - 077009

Published: July 1, 2024

The high-quality single crystals of Mohrite (MOH) with dimensions 7 × 6 3 mm were productively grown-up by the customary solution growth methodology. fully grown focused to appropriate structural, optical and electrical investigations. MOH is monoclinic nature specimen P2 1 /c as space group lattice parameters are a 6.2385 Å, b 12.6076 c 9.2655 Å beta 106.526°. crystalline structural authentication crystal XRD analysis compared same software based associated results. FITR spectra reveal vibrational modes crystals. Optical absorption spectral data divulges that as-grown sample has higher transparent in visible-NIR region. Photoluminescence intensity remarkably enriched, shows high crystallinity MOH. results UV, PL, photo conductivity, SEM, theoretical studies suggest photonic utility device appliances especially UV filters electronic filters, room temperature sensor study for enabled reported red LED work.

Language: Английский

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