Syndecan-1 in the Serum of Deceased Kidney Donors as a Potential Biomarker of Kidney Function

Transplantation Proceedings, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Global impact of proteoglycan science on human diseases

iScience, Journal Year: 2023, Volume and Issue: 26(11), P. 108095 - 108095

Published: Oct. 4, 2023

Language: Английский

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Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 leads to durable glioblastoma remission and immune memory in female mice

EBioMedicine, Journal Year: 2024, Volume and Issue: 105, P. 105202 - 105202

Published: June 20, 2024

Glioblastoma (GB), the most aggressive brain cancer, remains a critical clinical challenge due to its resistance conventional treatments. Here, we introduce locoregional targeted-α-therapy (TAT) with rat monoclonal antibody 9E7.4 targeting murine syndecan-1 (SDC1) coupled α-emitter radionuclide astatine-211 (

Language: Английский

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The Landscape of Small Leucine-Rich Proteoglycan Impact on Cancer Pathogenesis with a Focus on Biglycan and Lumican

Cancers, Journal Year: 2023, Volume and Issue: 15(14), P. 3549 - 3549

Published: July 9, 2023

Cancer development is a multifactorial procedure that involves changes in the cell microenvironment and specific modulations functions. A tumor contains cells, non-malignant blood vessels, cells of immune system, stromal extracellular matrix (ECM). The small leucine-rich proteoglycans (SLRPs) are family nineteen proteoglycans, which ubiquitously expressed among mammalian tissues especially abundant ECM. SLRPs divided into five canonical classes (classes I–III, containing fourteen members) non-canonical IV–V, including based on their amino-acid structural sequence, chromosomal organization, functional properties. Variations both protein core structure glycosylation status lead to SLRP-specific interactions with membrane receptors, cytokines, growth factors, ECM molecules. have been implicated regulation cancer growth, motility, invasion, as well cancer-associated inflammation autophagy, highlighting crucial role processes carcinogenesis. Except for class I SLRP decorin, an anti-tumorigenic has attributed, other SLPRs’ roles not fully clarified. This review will focus functions II members biglycan lumican, correlated various aspects development.

Language: Английский

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MicroRNA‐Modified DNA Hexahedron‐Induced Hepatocyte‐Like Cells Integrating 3D Printed Scaffold for Acute Liver Failure Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 18, 2024

Abstract Acute liver failure (ALF) involves extensive necrosis of cells and severe impairment function. Hepatocyte transplantation holds promise for treating ALF by swiftly supporting functions promoting regeneration. However, the scarcity suitable cell sources requires strategies to obtain enough functional hepatocyte‐like (HLCs) optimize their in vivo efficiency. A DNA hexahedral nanostructure (DHN) is developed loaded with microRNA‐122 efficiently induce hepatic differentiation human adipose‐derived mesenchymal stem into HLCs. These HLCs can serve as alternative hepatocyte sources, confirmed expression liver‐specific genes proteins, restoration functions. To enhance survival efficiency HLCs, a versatile scaffold also created 3D printing calcium‐cross‐linked mixture bioink composed sodium alginate, gelatin, silk fibroin excellent ROS scavenging capabilities. The infused chitosan‐DHN hydrogel containing tissue engineering orthotopic CCl 4 ‐induced mice. transplanted composite scaffold‐HLCs successfully repair injury area mice regulate expressions proteins associated inflammation, oxidative stress, Collectively, this study offers novel approach strategy identifying ALF.

Language: Английский

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Identification of cancer-associated fibroblast subtypes and prognostic model development in breast cancer: role of the RUNX1/SDC1 axis in promoting invasion and metastasis

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: Jan. 3, 2025

In this study, we identified cancer-associated fibroblast (CAF) molecular subtypes and developed a CAF-based prognostic model for breast cancer (BRCA). The heterogeneity of fibroblasts (CAFs) their significant involvement in the advancement BRCA were discovered employing single-cell RNA sequencing. Notably, that RUNX1/SDC1 axis enhances cell invasion metastasis. RUNX1 transcriptionally upregulates SDC1, which facilitates extracellular matrix remodeling promotes tumor migration. This finding highlights vital contribution CAFs to microenvironment provides new potential targets therapeutic intervention. predictive showcased remarkable precision anticipating patient outcomes could guide personalized treatment strategies.

Language: Английский

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Ribosome biogenesis: A central player in liver diseases

Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101512 - 101512

Published: Jan. 1, 2025

Language: Английский

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A Syndecan‐Mediated Journey

Proteoglycan Research, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 1, 2025

ABSTRACT A brief, personal, retrospective on my career is presented, focusing the path that led from studies fibroblast focal adhesions to signaling roles of syndecan‐4. This summary framed against backdrop major discoveries in cell adhesion field influenced our research direction, ultimately leading discovery events involve kinases, microfilament dynamics, and ion channels. Syndecan regulation stretch‐activated transient receptor potential channels appears be a property extends back invertebrates probably intrinsic their origins.

Language: Английский

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Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 21, 2025

Acute‐on‐chronic liver failure (ACLF) is a syndrome characterized by systemic inflammation with high short-term mortality rate. Syndecan-1 (SDC-1) can independently predict the 90-day of patients septic shock. However, role SDC-1 in ACLF remains unknown. In this study, serum levels were examined 2 cohorts, which included 174 patients. And mouse model induced tetrachloride, lipopolysaccharide, and D-galactosamine was established, to evaluate effects sulodexide heparan sulfate (side chains SDC-1) on vivo. Baseline 101 (847.72, 499.79–1511.37 ng/ml) significantly higher than healthy controls (33.58, 27.08–43.34 (P < 0.0001). The baseline who died or accepted transplantation within 90 days markedly those survived 0.05). A novel prognostic (UIAS) based upper gastrointestinal bleeding, INR, age, developed. AUROC UIAS score for 28-day deterioration 0.884, indicating an obviously greater predictive performance outcomes Child‐Pugh (AUROC = 0.646), MELD 0.713), COSSH‐ACLF II scores 0.713). Moreover, we found that could increase expression attenuate injury, promoting regeneration inhibiting cell apoptosis through activation JAK1/STAT3 signalling. Collectively, our findings suggest represents potential therapeutic target should be further investigated.

Language: Английский

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CHPF2 as a novel biomarker and ponicidin as a potential therapeutic agent in hepatocellular carcinoma

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107698 - 107698

Published: March 1, 2025

Language: Английский

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