Gestational Diabetes Mellitus: Unveiling Maternal Health Dynamics from Pregnancy Through Postpartum Perspectives DOI Creative Commons
Marina Mora-Ortiz, Lorenzo Rivas-García

Open Research Europe, Journal Year: 2024, Volume and Issue: 4, P. 164 - 164

Published: Nov. 12, 2024

Gestational Diabetes Mellitus (GDM) is the most frequent pregnancy-related medical issue and presents significant risks to both maternal foetal health, requiring monitoring management during pregnancy. The prevalence of GDM has surged globally in recent years, mirroring rise diabetes obesity rates. Estimated affect from 5% 25% pregnancies, impacts approximately 21 million live births annually, according International Federation (IDF). However, consensus on diagnostic approaches remains elusive, with varying recommendations international organizations, which makes comparison between research complicated. Compounding concerns are short-term long-term complications stemming for mothers offspring. Maternal outcomes include heightened cardiovascular a notable 70% risk developing Type 2 (T2DM) within decade postpartum. Despite this, into metabolic profiles associated previous predisposing women T2D limited. While genetic biomarkers have been identified, indicating multifaceted nature involving hormonal changes, insulin resistance, impaired secretion, there dearth exploration enduring health implications their children. Furthermore, offspring born shown face an increased syndrome childhood adolescence, studies ranging 20% 50%. This comprehensive review aims critically assess current landscape Gestational research, focusing its prevalence, challenges, By examining state-of-the-art knowledge identifying key gaps scientific literature, this highlight factors that hindered deeper understanding consequences. Ultimately, scholarly seeks promote further investigation critical area, improving children.

Language: Английский

Preeclampsia: A comprehensive review DOI

Majida Ali,

Madiha Ahmed,

Mehwish Memon

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 563, P. 119922 - 119922

Published: Aug. 13, 2024

Language: Английский

Citations

8
Gestational Diabetes Mellitus: Unveiling Maternal Health Dynamics from Pregnancy Through Postpartum Perspectives DOI Creative Commons
Marina Mora-Ortiz, Lorenzo Rivas-García

Open Research Europe, Journal Year: 2024, Volume and Issue: 4, P. 164 - 164

Published: Aug. 5, 2024

Gestational Diabetes Mellitus (GDM) is the most frequent pregnancy-related medical issue and presents significant risks to both maternal foetal health, requiring monitoring management during pregnancy. The prevalence of GDM has surged globally in recent years, mirroring rise diabetes obesity rates. Estimated affect from 5% 25% pregnancies, impacts approximately 21 million live births annually, according International Federation (IDF). However, consensus on diagnostic approaches remains elusive, with varying recommendations international organizations, which makes comparison between research complicated. Compounding concerns are short-term long-term complications stemming for mothers offspring. Maternal outcomes include heightened cardiovascular a notable 70% risk developing Type 2 (T2DM) within decade postpartum. Despite this, into metabolic profiles associated previous predisposing women T2D limited. While genetic biomarkers have been identified, indicating multifaceted nature involving hormonal changes, insulin resistance, impaired secretion, there dearth exploration enduring health implications their children. Furthermore, offspring born shown face an increased syndrome childhood adolescence, studies ranging 20% 50%. This comprehensive review aims critically assess current landscape Gestational research, focusing its prevalence, challenges, By examining state-of-the-art knowledge identifying key gaps scientific literature, this highlight factors that hindered deeper understanding consequences. Ultimately, scholarly seeks promote further investigation critical area, improving children.

Language: Английский

Citations

4
Endothelial METAP1: Tipping the Angiogenic Scales in Postpartum Preeclampsia DOI
Jessica Faulkner, Matthew R. Alexander

Circulation Research, Journal Year: 2025, Volume and Issue: 136(2), P. 191 - 193

Published: Jan. 16, 2025

Language: Английский

Citations

0
Exploring the soluble (pro)renin receptor (sPRR) as a biomarker in pathophysiological disorders: Integrating machine learning and meta-analysis for insights into gestational diabetes DOI
Amir Hossein Aalami, Mohammad Rahimi, Amirhossein Sahebkar

et al.

Expert Systems with Applications, Journal Year: 2025, Volume and Issue: unknown, P. 126998 - 126998

Published: Feb. 1, 2025

Language: Английский

Citations

0
Effect of Combined Gestational Diabetes Mellitus and Preeclampsia on Pregnancy Outcomes DOI Creative Commons

Huangxiaoyu Li,

Binbin Yin,

Nan Jiang

et al.

Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2025, Volume and Issue: 52(2)

Published: Feb. 24, 2025

Background: Gestational diabetes mellitus (GDM) and preeclampsia (PE) significantly increase the risk of adverse pregnancy outcomes. However, effect on outcomes GDM in combination with PE remains undetermined. Therefore, this study aimed to investigate pregnant women PE. Methods: This retrospective cohort was conducted at a single center. To explore correlations between occurrence outcomes, enrolled population divided into two groups: non-GDM. Risk factors associated were analyzed using binary logistic regression model. Results: comprised 27,181 (5412 cases 21,769 non-GDM cases). The prevalence higher group than (p < 0.05). presence GDM, pre-pregnancy body mass index (pp-BMI) >24 kg/m2, excessive gestational weight gain (GWG) demonstrated contribute an increased developing Pregnant exhibited preterm birth. Additionally, birth, cesarean section, fetal growth restriction further when occurred alongside GDM. Conclusions: Overall, pp-BMI kg/m2 GWG for have PE, co-occurrence increases attention management are needed during pregnancy.

Language: Английский

Citations

0
Associations of >1-hour versus ≤1-hour meal timing variability (eating jetlag) with plasma glycemic parameters and continuous glucose monitoring measures among pregnant females: A prospective cohort study DOI
Yu-En Chen, Chee Wai Ku,

Mary F-F Chong

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Molecular Insights to Adiponectin in Pregnancy Pathologies: A Systematic Review on Physiological and Clinical Pathological Perspective DOI Creative Commons

Saima Naz Shaikh,

Noor Un Nisa Memon,

Rabia Zuhaib

et al.

Pakistan Journal of Medicine and Dentistry, Journal Year: 2025, Volume and Issue: 14(2), P. 515 - 523

Published: April 13, 2025

Background: Adiponectin was seen to work as an important adipokine that originated from adipocytes regulate metabolic and inflammatory processes. The concentration of adiponectin altered throughout pregnancy, linking it different pregnancy-related medical complications. This review aimed investigate how affects pregnancy pathologies at the molecular level, while examining both normal physiological events associated outcomes. Methods: A thorough analysis research conducted through examination peer-reviewed studies in PubMed, Scopus, Google Scholar databases 2010 2024. included functions during about gestational diabetes mellitus (GDM), preeclampsia, insulin resistance, hypertension. experimental studies, prospective cohort case-control studies. excluded papers failed mention definitive outcomes regarding those dealing exclusively with non-pregnancy conditions. systematic 12 which received quality evaluation application Evidence Project Risk Bias Tool. Results were synthesized qualitatively. Results: Among 118 screened 34 met eligibility criteria after full-text review. finally sample size ranged 2503 participants. Pregnant women typically exhibited elevated levels early but this level decreased cases GDM preeclampsia. Studies have shown regulates three key elements for complications, include sensitivity, endothelial function connection between impaired glucose metabolism patients reduced vasodilatory anti-inflammatory effects influences preeclampsia these Research also indicated influenced fetal development by affecting placenta’s ability support nutritional needs. Discussion: potential existence represented a biomarker therapeutic target

Language: Английский

Citations

0
Emerging Role of Leptin in Vascular and Placental Dysfunction in Preeclampsia DOI
Mona Elgazzaz, Amalia Brawley, Desmond Moronge

et al.

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Leptin is a well-known metabolic hormone that plays diverse roles in various body functions, including growth, reproduction, and blood pressure regulation. In pregnancy, leptin produced from the placenta crucial for ensuring proper fetal development angiogenesis; however, pathological increases maternal circulation are strongly associated with vascular endothelial dysfunction preeclampsia. has strong role fertility healthy pregnancy; numerous clinical reports over last 2 decades show levels pathologically increase patients preeclampsia independent of status (ie, obesity). Despite this correlation, largely unexplored compared other biomarkers likely due to differences placental production among mammals. Emerging literature recently begun shed light on pathogenesis uncovered some key mechanisms whereby elevated leads cardiovascular complications pregnant women.

Language: Английский

Citations

0
Mid-late Gestation Leptin Infusion Induces Placental Mitochondrial and Endoplasmic Reticulum Unfolded Protein Responses in a Mouse Model of Preeclampsia DOI Creative Commons
Jessica Faulkner, Mayumi Takano,

Safia Ogbi

et al.

Placenta, Journal Year: 2024, Volume and Issue: 158, P. 253 - 262

Published: Nov. 2, 2024

Language: Английский

Citations

2
Exploration the Effects of Mesenchymal Stem Cells and Olive Leaf Extract on Physiological and Histopathological Changes on the Kidney of Diabetes Rats DOI Creative Commons

Mervat Ahmed AbdRabou,

Ahmed Atwa, Zahrah R Alrayes

et al.

Cellular Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 58(6), P. 807 - 822

Published: Dec. 28, 2024

Background/Aims: Gestational Diabetes Mellitus (GDM) is a common complication during pregnancy, defined as diabetes diagnosed in the second or third trimester, often asymptomatic. This study investigates therapeutic potential of olive leaf extracts and stem cells mitigating GDM-induced complications, particularly focusing on renal function, oxidative stress, pancreatic cell regeneration. Methods: Measurements were made gravid female rats with without intraperitoneal administration Streptozotocin (35 mg/kg body weight). Biochemical analyses conducted to evaluate function markers (urea, uric acid, creatinine) stress parameters (malondialdehyde, glutathione, superoxide dismutase levels). Histopathological immunohistopathological evaluations kidney tissues performed using hematoxylin eosin staining specific (p53, Insulin, PCNA) assess cellular changes. Results: The diabetic group exhibited significantly elevated levels urea, creatinine (p<0.01) compared control group. Treatment reduced these levels. Malondialdehyde but showed marked improvement treatment groups. Additionally, glutathione activities diminished (p<0.05) increased following treatment. revealed regeneration improved tissue morphology groups Conclusion: Stem exhibit significant ameliorating dysfunction, damage associated GDM, highlighting their role enhancing

Language: Английский

Citations

1