Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids

Pediatric Research, Journal Year: 2024, Volume and Issue: 96(2), P. 510 - 518

Published: March 13, 2024

Language: Английский

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Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(35)

Published: Aug. 22, 2024

Dynamic brain immune function in individuals with posttraumatic stress disorder is rarely studied, despite evidence of peripheral dysfunction. Positron emission tomography imaging using the radiotracer [ 11 C]PBR28 was used to measure 18-kDa translocator protein (TSPO), a microglial marker, at baseline and 3 h after administration lipopolysaccharide (LPS), potent activator. Data were acquired 15 PTSD age-matched controls. The group exhibited significantly lower magnitude LPS-induced increase TSPO availability an priori prefrontal-limbic circuit compared Greater anhedonic symptoms associated more suppressed neuroimmune response. In addition, while reduced granulocyte–macrophage colony-stimulating factor response LPS observed group, other measured cytokine responses self-reported sickness did not differ between groups; these findings highlight differences central–peripheral system relationships. results this study provide microglia-mediated direct insult that severity symptoms. They also further support emerging literature challenging traditional concepts psychiatric disease.

Language: Английский

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Modeling the Influence of Chronic Sleep Restriction on Cortisol Circadian Rhythms, with Implications for Metabolic Disorders

Metabolites, Journal Year: 2021, Volume and Issue: 11(8), P. 483 - 483

Published: July 27, 2021

Chronic sleep deficiency is prevalent in modern society and associated with increased risk of metabolic other diseases. While the mechanisms by which chronic induces pathophysiological changes are yet to be elucidated, hypothalamic–pituitary–adrenal (HPA) axis may an important mediator these effects. Cortisol, primary hormone HPA axis, exhibits robust circadian rhythmicity moderately influenced wake states physiology. Several studies have explored effects acute or (i.e., usually from self-selected restriction, CSR) on axis. Quantifying long-term rhythm cortisol under CSR controlled conditions inadequately studied due practical limitations. We use a semi-mechanistic mathematical model sleep/wake cycle explore influence rhythmicity. In qualitative agreement experimental findings, simulations predict that results physiologically relevant disruptions phase amplitude rhythm. The presented this work provides mechanistic framework further how might lead disruption subsequent development complications.

Language: Английский

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Interactions of Noradrenergic, Glucocorticoid and Endocannabinoid Systems Intensify and Generalize Fear Memory Traces

Neuroscience, Journal Year: 2021, Volume and Issue: 497, P. 118 - 133

Published: Sept. 22, 2021

Language: Английский

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Interleukin-6 secretion upon acute psychosocial stress as a potential predictor of psychotherapy outcome in posttraumatic stress disorder

Journal of Neural Transmission, Journal Year: 2021, Volume and Issue: 128(9), P. 1301 - 1310

Published: May 14, 2021

Language: Английский

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