T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota. DOI Open Access
Patricia Souza,

Catherine M. Keenan,

Laurie E. Wallace

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 24, 2024

Abstract The gut microbiota and immune system maintain intestinal homeostasis regulate physiology in concert with the enteric nervous (ENS). However, underlying mechanisms remain incompletely understood. Using wildtype T-cell deficient germ-free mice colonized segmented filamentous bacteria (SFB) or specific pathogen-free (SPF) microbiota, we studied regulation of ENS motility. Colonization markedly increased Th17 cells Treg expressing RORγ + T both ileum colon mice. were necessary for normalization motility after colonization by SPF SFB to restore neuronal density also required neurogenic responses myenteric neurons ileum, but not colon, regulating levels nestin expression. cytokines IL-1β IL-17A mediate response an involved Together, our findings provide new insights into microbiota-neuroimmune dialogue that regulates physiology.

Language: Английский

The Neuroimmune Axis in Gastrointestinal Disorders – An Underrecognized Problem DOI
Laura Pace,

Niwen Kong,

Mohamed I Itani

et al.

Current Gastroenterology Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 15, 2025

Language: Английский

Citations

0
Navigating through 65 years of insights: lessons learned on functional abdominal pain in children DOI
Shaman Rajindrajith, Christopher Chiong-Meng Boey, Niranga Manjuri Devanarayana

et al.

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(9), P. 3689 - 3703

Published: July 8, 2024

Language: Английский

Citations

2
T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota DOI Creative Commons
Patricia Souza,

Catherine M. Keenan,

Laurie E. Wallace

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 20, 2024

How the gut microbiota and immune system maintain intestinal homeostasis in concert with enteric nervous (ENS) remains incompletely understood. To address this gap, we assessed small transit, neuronal density, neurogenesis, microbiota, cell populations cytokines wildtype T-cell deficient germ-free mice colonized specific pathogen-free (SPF) conventionally raised SPF segmented filamentous bacteria (SFB)-monocolonized mice. increased transit a T cell-dependent manner. density myenteric submucosal plexuses of ileum colon, similar to mice, independently cells. SFB manner, but cells colon. stimulated neurogenesis (Sox2 expression neurons) colon effect was cell-independent. regulated nestin ENS. colonization Th17 cells, RORγT+ Treg IL-1β IL-17A levels By neutralizing IL-17A, observed that they control microbiota-mediated were not involved regulation motility. Together, these findings provide new insights into microbiota-neuroimmune dialog regulates physiology.

Language: Английский

Citations

1
T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota. DOI Open Access
Patricia Souza,

Catherine M. Keenan,

Laurie E. Wallace

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 24, 2024

Abstract The gut microbiota and immune system maintain intestinal homeostasis regulate physiology in concert with the enteric nervous (ENS). However, underlying mechanisms remain incompletely understood. Using wildtype T-cell deficient germ-free mice colonized segmented filamentous bacteria (SFB) or specific pathogen-free (SPF) microbiota, we studied regulation of ENS motility. Colonization markedly increased Th17 cells Treg expressing RORγ + T both ileum colon mice. were necessary for normalization motility after colonization by SPF SFB to restore neuronal density also required neurogenic responses myenteric neurons ileum, but not colon, regulating levels nestin expression. cytokines IL-1β IL-17A mediate response an involved Together, our findings provide new insights into microbiota-neuroimmune dialogue that regulates physiology.

Language: Английский

Citations

0