Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 23, 2025

Language: Английский

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Gut-brain pathogenesis of post-acute COVID-19 neurocognitive symptoms

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 28, 2023

Approximately one third of non-hospitalized coronavirus disease 2019 (COVID-19) patients report chronic symptoms after recovering from the acute stage severe respiratory syndrome 2 (SARS-CoV-2) infection. Some most persistent and common complaints this post-acute COVID-19 (PACS) are cognitive in nature, described subjectively as “brain fog” also objectively measured deficits executive function, working memory, attention, processing speed. The mechanisms these sequelae currently not understood. SARS-CoV-2 inflicts damage to cerebral blood vessels intestinal wall by binding angiotensin-converting enzyme (ACE2) receptors evoking production high levels systemic cytokines, compromising brain’s neurovascular unit, degrading barrier, potentially increasing permeability both harmful substances. Such substances hypothesized be produced gut pathogenic microbiota that, given profound effects has on gastrointestinal system, may fourish a result post-COVID-19 dysbiosis. therefore create scenario which neurotoxic neuroinflammatory readily proliferate lumen encounter weakened gaining access brain subsequently producing deficits. Here, we review proposed PACS pathogenesis along gut-brain axis, while identifying specific methodologies that available experimentally measure each individual component model.

Language: Английский

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Robust cross-cohort gut microbiome associations with COVID-19 severity

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: Aug. 7, 2023

Although many recent studies have examined associations between the gut microbiome and COVID-19 disease severity in individual patient cohorts, questions remain on robustness across international cohorts of biomarkers they reported. Here, we performed a meta-analysis eight shotgun metagenomic patients (comprising 1,023 stool samples) 23 > 16S rRNA gene amplicon sequencing (16S) (2,415 total samples). We found that (as defined by WHO clinical progression scale) was associated with taxonomic functional differences. This alteration configuration peaks at days 7–30 post diagnosis, after which returns to becomes more similar healthy controls over time. Furthermore, identified core set species were consistently whose abundance can accurately predict category SARS-CoV-2 infected subjects, Actinomyces oris predicting population-level mortality rate COVID-19. Additionally, used relational diet-microbiome databases constructed from cohort microbiota-targeted diet patterns would modulate microbiota composition toward controls. Finally, demonstrated association intestinal archaeal, fungal, viral, parasitic communities. Collectively, this study has robust biomarkers, established accurate predictive models as basis for prognostic tests severity, proposed biomarker-targeted diets managing infection.

Language: Английский

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A blood supply pathophysiological microcirculatory mechanism for the Long COVID

Published: July 30, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID‑19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case-control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused vessels (PPVR). Both ML hemodynamic decrease (HD), incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Language: Английский

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Inflammation and the oral and gut microbiota with COVID-19

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 207 - 218

Published: Jan. 1, 2025

Language: Английский

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Clinical Characteristics During and After COVID‐19 Infection Among Healthcare Workers During the First Wave of Omicron in Chongqing, China

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Revealing the clinical manifestations and associations of COVID-19 before after negative transition remains an area significant uncertainty. The aim this study is to investigate characteristics observed during Omicron infection among a specific population, namely healthcare workers (HCWs). From November 4, 2022, January 15, 2023, HCWs in our hospital were enrolled document symptoms, prevention, treatment for using structured questionnaire. A total 1101 included, with SARS-CoV-2 detected 78.20% (861/1101) observation period. median duration nucleic acid conversion was 8 days. Forty-three symptoms identified (11 per individual). common fever, cough, headache, phlegm production, fatigue (60.67%-83.29%). These can be further categorized into five groups: fever type, upper respiratory tract influenza digestive system systemic type-all showing complex diverse patterns. Following infection, 19 recorded including four newly emerged ones: reduced lung capacity, memory loss, lethargy, inattention. Importantly, we association between gastrointestinal positive phase subsequent neuropsychiatric conversion. Interestingly, females experiencing menstruation or pregnancy exhibited higher risk while inhaled vaccines thymosin demonstrated protective effect against infection. displayed intricate patterns, shedding new light on interplay humans.

Language: Английский

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The Role of Nutraceuticals in the Prevention and/or Treatment of COVID-19: An Umbrella Review

CAND Journal, Journal Year: 2023, Volume and Issue: 30(4), P. 66 - 80

Published: Dec. 28, 2023

Background: To identify the results of published review literature regarding nutraceuticals, including probiotics, melatonin, poly-unsaturated fatty acids (PUFAs), quercetin, N-acetyl cysteine (NAC), and propolis as they relate to prevention and/ or treatment COVID-19 (CV) and/or long COVID (long CV) outline key areas consider for clinical application further research. Methods: This paper is part a six-part umbrella which progresses from living review. incorporates systematic reviews narrative nutraceuticals. A live search occurred monthly in PubMed Google Scholar May 2022 2023. Assessing Methodological Quality Systematic Reviews Version 2 (AMSTAR-2) scoring assessed quality, while Scale Assessment Narrative Review Articles (SANRA) guidelines evaluated reviews. Only those studies that were relevant nutraceuticals outlined above addressed CV extracted each Results: Fifteen 16 included this Studies indicate may be beneficial improving rate recovery various symptoms, conversion parameters such duration hospital stay risk intensive care unit (ICU) admission, an improvement laboratory tests. Conclusion/Summary: The broad antioxidant, anti-inflammatory, antiviral, immune modulatory characteristics make reasonable choices Of discussed above, NAC, quercetin greatest potential benefit CV.

Language: Английский

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A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1076 - 1076

Published: Aug. 28, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID-19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case–control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused (PPVR). Both ML hemodynamic decrease (HD) incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Language: Английский

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Gut microbe–host interactions in post-COVID syndrome: a debilitating or restorative partnership?

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 17, 2024

Post-COVID syndrome (PCS) patients have reported a wide range of symptoms, including fatigue, shortness breath, and diarrhea. Particularly, the presence gastrointestinal symptoms has led to hypothesis that gut microbiome is involved in development severity PCS. The objective this review provide an overview role PCS by describing microbial composition metabolites COVID-19 Moreover, host-microbe interactions via microbiota-gut-brain (MGB) microbiota-gut-lung (MGL) axes are described. Furthermore, we explore potential therapeutically targeting support recovery reviewing preclinical model systems clinical studies. Overall, current studies evidence microbiota affected PCS; however, diversity highly individual compositions suggest need for personalized medicine. Gut-targeted therapies, treatments with pre- probiotics, improve quality life individuals.

Language: Английский

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Gastrointestinal pathophysiology in long COVID: Exploring roles of microbiota dysbiosis and serotonin dysregulation in post-infectious bowel symptoms

Life Sciences, Journal Year: 2024, Volume and Issue: 358, P. 123153 - 123153

Published: Oct. 23, 2024

Language: Английский

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