Functions and application of circRNAs in vascular aging and aging-related vascular diseases DOI Creative Commons

Sen He,

Bei Huang, Feng Xu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 17, 2025

Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding generated through the reverse splicing mRNA precursors, possess capacity to regulate gene transcription and translation. Recently, pivotal role circRNAs in controlling vascular aging, as well pathogenesis progression aging-related diseases, has garnered substantial attention. Vascular aging plays crucial increased morbidity mortality elderly. Endothelial cells (ECs) smooth muscle (VSMCs) are components intima media layers wall, respectively, closely involved mechanisms underlying diseases. The review aims provide comprehensive exploration connection between Besides, circRNAs, potential diagnostic markers or therapeutic targets for will be discussed thoroughly, along with challenges limitations their clinical application. Investigating molecular diseases insight into early diagnosis therapy, even effective prognosis assessment these conditions.

Language: Английский

Functions and application of circRNAs in vascular aging and aging-related vascular diseases DOI Creative Commons

Sen He,

Bei Huang, Feng Xu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 17, 2025

Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding generated through the reverse splicing mRNA precursors, possess capacity to regulate gene transcription and translation. Recently, pivotal role circRNAs in controlling vascular aging, as well pathogenesis progression aging-related diseases, has garnered substantial attention. Vascular aging plays crucial increased morbidity mortality elderly. Endothelial cells (ECs) smooth muscle (VSMCs) are components intima media layers wall, respectively, closely involved mechanisms underlying diseases. The review aims provide comprehensive exploration connection between Besides, circRNAs, potential diagnostic markers or therapeutic targets for will be discussed thoroughly, along with challenges limitations their clinical application. Investigating molecular diseases insight into early diagnosis therapy, even effective prognosis assessment these conditions.

Language: Английский

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