Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 211 - 211
Published: March 20, 2025
Background: Diet is a key modifiable factor that can either support renal health or accelerate the onset and progression of chronic kidney disease (CKD). Recent advances in multiomics, particularly proteomics metabolomics, significantly enhanced our understanding molecular mechanisms linking diet to CKD risk. Proteomics offers comprehensive analysis protein expression, structure, interactions, revealing how dietary components regulate cellular processes signaling pathways. Meanwhile, metabolomics provides detailed profile low-molecular-weight compounds, including endogenous metabolites diet-derived molecules, offering insights into metabolic states influence function. Methods: We have conducted narrative review papers from databases such as PubMed, Scopus, Web Science explore potential proteomic metabolomic identifying signatures associated with human animal biological samples, blood plasma, urine, tissues. These help elucidate specific foods, food groups, overall patterns may contribute mitigate Results: studies impact high-fat diets on expression involved energy metabolism, inflammation, fibrosis, early biomarkers injury. Metabolic, disruptions fatty acid glucose regulation, amino pathways, been recognized indicators Additionally, several found fluids tissue response protein-rich assessing their roles progressive loss Emerging evidence also suggests interventions targeting gut microbiota alleviate oxidative stress, toxin accumulation disease. Notably, recent findings highlight linked beneficial shifts microbial context prebiotic supplementation. Conclusions: By integrating future research refine precision nutrition strategies, helping progression. Expanding large-scale clinical trials will be essential translating these actionable guidelines.
Language: Английский