Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy DOI Creative Commons

Yajuan Wan,

Guoqing Li,

Gaoyuan Cui

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 11, 2025

Abstract Thyroid cancer as one of the most prevalent malignancies endocrine system, has raised public concern and more research on its mechanism treatment. And metabolism-based therapies have advanced rapidly, for exclusive metabolic profiling thyroid cancer. In cells, plenty pathways are reprogrammed to accommodate tumor microenvironment. this review, we initiatively summarize recent progress in full-scale rewiring interconnection various metabolites. We also discuss efficacy prospect targeted detection well therapy. Comprehending characteristics roundly will be highly beneficial managing individual patients.

Language: Английский

Effects of different types of ginseng on intercellular wireless communication networks and central carbon metabolism pathways DOI
Yujiao Liu,

Dingqiang Lu,

Jiayi Qiang

et al.

Journal of Future Foods, Journal Year: 2025, Volume and Issue: 5(6), P. 572 - 581

Published: Jan. 29, 2025

Language: Английский

Citations

0
Skeletal muscle growth to combat diabetes and obesity: the potential role of muscle‐secreted factors DOI Creative Commons
Mitchell J. Sammut,

Benjamin R. Thorne,

C.W. James Melling

et al.

Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract As the prevalence of obesity and metabolic disease continues to climb, need for effective therapeutic interventions remains high. The growth skeletal muscle (SkM) greatly influences systemic metabolism across whole body, making this tissue an important target combat rise dysfunction. Transgenic rodent models targeted SkM exhibit profound improvements in various remote tissues, including adipose liver. It is currently unclear how selective stimulation alters distant tissues; however, evidence suggests that muscle‐secreted factors may be involved. Here, we aim provide basic biomedical researchers with a summary current knowledge regarding regulated by anabolic pathways proteins SkM, as well their effects, implicate them whole‐body effects growth. In review, also identify several gaps field, future directions investigation, implications such resistance exercise pharmacology. image

Language: Английский

Citations

0
Exerkines: Potential regulators of ferroptosis DOI Creative Commons
Min Jia,

Fengxing Li,

Tong Wu

et al.

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101032 - 101032

Published: Feb. 1, 2025

Ferroptosis is a programmed cell death, and its mechanism involves multiple metabolic pathways, such as iron lipid metabolism, redox homeostasis. Exerkines are important mediators that optimize cellular homeostasis maintain physiological health during exercise stimulation. This article comprehensively examines the mechanisms regulatory networks for governing ferroptosis summarizes impact of exerkines on under varying load intensities disease contexts. Notably, despite significant efficacy minimal side effects, therapeutic prognostic potential in ferroptosis-related diseases remains largely unexplored. article, by summarizing recent progresses regulation exerkines-mediated ferroptosis, could further uncover preventive or alleviative some upon interventions, which will be beneficial to design interventional strategies alleviating progression through ferroptosis.

Language: Английский

Citations

0
The contemporary role of lactate in exercise physiology and exercise prescription – a review of the literature DOI Creative Commons
Nikolay Mandadzhiev

Folia Medica, Journal Year: 2025, Volume and Issue: 67(1)

Published: Feb. 24, 2025

Lactate is a key molecule in exercise metabolism. In the last two decades, there has been revolution understanding of its role – from byproduct hypoxic muscles to major energy resource and signaling ‘lactormone’. The aim this review compile all up-to-date information that available on general metabolism lactate, but also specific use physiologists, coaches, athletes can get out lactate measurements, lactate-based training zones, periodization sessions. Since lactate’s normal disease late 20th century, more evidence assembled regarding part it plays exercise. From vast body knowledge, researchers developed concept intensity distribution into zones according level blood lactate. end goal or ‘threshold’ increased adaptation stimuli ultimately better performance, which backed up by achievements numerous concept.

Language: Английский

Citations

0
Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy DOI Creative Commons

Yajuan Wan,

Guoqing Li,

Gaoyuan Cui

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 11, 2025

Abstract Thyroid cancer as one of the most prevalent malignancies endocrine system, has raised public concern and more research on its mechanism treatment. And metabolism-based therapies have advanced rapidly, for exclusive metabolic profiling thyroid cancer. In cells, plenty pathways are reprogrammed to accommodate tumor microenvironment. this review, we initiatively summarize recent progress in full-scale rewiring interconnection various metabolites. We also discuss efficacy prospect targeted detection well therapy. Comprehending characteristics roundly will be highly beneficial managing individual patients.

Language: Английский

Citations

0