Mixed representations of sound and action in the auditory midbrain
Journal of Neuroscience,
Journal Year:
2024,
Volume and Issue:
44(30), P. e1831232024 - e1831232024
Published: June 25, 2024
Linking
sensory
input
and
its
consequences
is
a
fundamental
brain
operation.
During
behavior,
the
neural
activity
of
neocortical
limbic
systems
often
reflects
dynamic
combinations
task-dependent
variables,
these
“mixed
representations”
are
suggested
to
be
important
for
perception,
learning,
plasticity.
However,
extent
which
such
integrative
computations
might
occur
outside
forebrain
less
clear.
Here,
we
conduct
cellular-resolution
two-photon
Ca
2+
imaging
in
superficial
“shell”
layers
inferior
colliculus
(IC),
as
head-fixed
mice
either
sex
perform
reward-based
psychometric
auditory
task.
We
find
that
individual
shell
IC
neurons
jointly
cues,
mice's
actions,
behavioral
trial
outcomes,
trajectories
population
diverge
depending
on
choice.
Consequently,
simple
classifier
models
trained
neuron
can
predict
trial-by-trial
even
when
training
data
restricted
occurring
prior
instrumental
actions.
Thus,
behaving
mice,
midbrain
transmit
code
joint
representation
sound,
variables.
Language: Английский
Mixed representations of sound and action in the auditory midbrain
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 19, 2023
Linking
sensory
input
and
its
consequences
is
a
fundamental
brain
operation.
Accordingly,
neural
activity
of
neo-cortical
limbic
systems
often
reflects
dynamic
combinations
behaviorally
relevant
variables,
these
"mixed
representations"
are
suggested
to
be
important
for
perception,
learning,
plasticity.
However,
the
extent
which
such
integrative
computations
might
occur
in
regions
upstream
forebrain
less
clear.
Here,
we
conduct
cellular-resolution
2-photon
Ca
Language: Английский
Neurons in the inferior colliculus use multiplexing to encode features of frequency-modulated sweeps
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Within
the
central
auditory
pathway,
inferior
colliculus
(IC)
is
a
critical
integration
center
for
ascending
sound
information.
Previous
studies
have
shown
that
many
IC
neurons
exhibit
receptive
fields
individual
features
of
stimuli,
such
as
frequency,
intensity,
and
location,
but
growing
evidence
suggests
some
may
multiplex
sound.
Here,
we
used
in
vivo
juxtacellular
recordings
awake,
head-fixed
mice
to
examine
how
responded
frequency-modulated
sweeps
varied
speed,
direction,
frequency
range.
We
then
applied
machine
learning
methods
determine
encode
FM
sweeps.
found
sweep
using
various
strategies
including
spike
timing,
distribution
inter-spike
intervals,
first
latency.
In
addition,
decoding
accuracy
direction
can
vary
with
speed
range,
suggesting
presence
mixed
selectivity
single
neurons.
Accordingly,
static
alone
yielded
poor
predictions
neuron
responses
vocalizations
contain
simple
changes.
Lastly,
showed
encoding
across
neurons,
resulting
highly
informative
population
response
features.
Together,
our
results
suggest
multiplexing
common
mechanism
by
represent
complex
sounds.
Language: Английский
Population coding of auditory space in the dorsal inferior colliculus persists with altered binaural cues
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
Sound
localization
is
critical
for
real-world
hearing,
such
as
segregating
overlapping
sound
streams.
For
optimal
flexibility,
central
representations
of
auditory
space
must
adapt
to
peripheral
changes
in
binaural
cue
availability,
following
asymmetric
hearing
loss
adulthood.
However,
whether
the
mature
system
can
reliably
encode
spatial
upon
abrupt
input
unclear.
Here
we
use
2-photon
Ca
Language: Английский