Frontiers in Neuroendocrinology, Journal Year: 2024, Volume and Issue: 75, P. 101154 - 101154

Published: Sept. 1, 2024

Astrocytes are now recognized as integral components of neural circuits, regulating their maturation, activity and plasticity. Neuroendocrinology has provided fertile ground for revealing the diverse strategies used by astrocytes to regulate physiological behavioural outcomes circuit in response internal environmental inputs. However, development hypothalamus received much less attention than other brain regions such cerebral cortex spinal cord. In this review, we synthesize our current knowledge astrogenesis across various life stages. A distinctive feature hypothalamic is that it persists life-long, involves multiple cellular sources corresponding radial glial cells during early development, followed tanycytes, parenchymal progenitors locally dividing astrocytes. Astrogenesis closely coordinated with maturation neurons. This coordination exemplified recent findings neurons producing gonadotropin-releasing hormone, which actively shape astroglial environment infancy integrate functionally into network facilitate sexual a process vulnerable endocrine disruption. While shares common principles regions, also exhibits specific features its dynamics regulation, both at inter- intra-regional levels. These unique properties emphasize importance further exploration. Additionally, discuss experimental assess potential bias limitations. Understanding mechanisms throughout will be crucial comprehending function under pathological conditions.

Language: Английский