Colloids and Surfaces B Biointerfaces,
Journal Year:
2020,
Volume and Issue:
190, P. 110949 - 110949
Published: March 9, 2020
Microbial
infections
lead
to
elevated
inflammatory
responses,
which
usually
result
in
prolonged
and
incomplete
wound
healing.
Therefore,
there
is
an
increasing
demand
for
biodegradable
fibres
that
are
effective
against
a
different
range
of
microorganisms,
especially
those
with
antibiotic
resistance.
Herein,
quercetin-(Q)-loaded
polylactide-based
were
developed
using
the
electrospinning
technique.
Since
Q
exhibits
low
chemical
stability,
we
used
star-shaped
polylactides
(PLAs)
β-CD
core
host
by
inclusion
complexation.
To
enhance
stability
additionally
entrap
between
polymeric
chains,
adapted
supramolecular
cross-linking
stereocomplexation
PLAs
opposite
configurations.
As
control,
prepared
additional
formulation
star-shaped/commercial
PLA/Q
preparation
nonwovens
moiety
was
not
present.
All
smooth
continuous,
average
diameter
37
μm.
Although
did
possess
diffusible
activity,
good
antibacterial
effects
Staphylococcus
aureus
(S.
aureus),
Escherichia
coli
(E.coli)
Klebsiella
pneumoniae
(K.
pneumoniae)
observed.
these
features
validate
proposed
approach,
interactions
modify
properties
PLA-based
and,
most
importantly,
show
their
great
potential
usefulness
microbial
infections.
EBioMedicine,
Journal Year:
2021,
Volume and Issue:
73, P. 103627 - 103627
Published: Oct. 15, 2021
Disordered
metabolic
states,
which
are
characterised
by
hypoxia
and
elevated
levels
of
metabolites,
particularly
lactate,
contribute
to
the
immunosuppression
in
tumour
microenvironment
(TME).
Excessive
lactate
secreted
metabolism-reprogrammed
cancer
cells
regulates
immune
responses
via
causing
extracellular
acidification,
acting
as
an
energy
source
shuttling
between
different
cell
populations,
inhibiting
mechanistic
(previously
'mammalian')
target
rapamycin
(mTOR)
pathway
cells.
This
review
focuses
on
recent
advances
regulation
well
therapeutic
strategies
targeting
anabolism
transport
TME,
such
those
involving
glycolytic
enzymes
monocarboxylate
transporter
inhibitors.
Considering
multifaceted
roles
metabolism,
a
comprehensive
understanding
how
lactate-targeting
therapies
regulate
TME
will
provide
insights
into
complex
relationships
metabolism
antitumour
immunity.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
39(12), P. 110986 - 110986
Published: June 1, 2022
Regulatory
T
(Treg)
cells
play
a
vital
role
in
maintaining
the
immunosuppressive
tumor
microenvironment.
Lactate
is
crucial
metabolite
cancer
and
related
to
prognosis,
metastasis,
overall
survival.
In
this
study,
we
focus
on
effects
of
lactate
Treg
cells.
vitro,
improves
cell
stability
function,
whereas
degradation
reduces
induction,
increases
antitumor
immunity,
decreases
growth
mice.
Mechanistically,
modulates
generation
through
lactylation
Lys72
MOESIN,
which
MOESIN
interaction
with
transforming
factor
β
(TGF-β)
receptor
I
downstream
SMAD3
signaling.
Cotreatment
anti-PD-1
dehydrogenase
inhibitor
has
stronger
effect
than
alone.
Individuals
hepatocellular
carcinoma
who
responded
treatment
have
lower
levels
nonresponding
individuals.
Thus,
identify
as
an
essential
small
molecule
that
reinforces
microenvironment
lactylation.
EBioMedicine,
Journal Year:
2019,
Volume and Issue:
44, P. 675 - 690
Published: April 24, 2019
BackgroundDysbiotic
vaginal
microbiota
have
been
implicated
as
contributors
to
persistent
HPV-mediated
cervical
carcinogenesis
and
genital
inflammation
with
mechanisms
unknown.
Given
that
cancer
is
a
metabolic
disease,
profiling
of
the
cervicovaginal
microenvironment
has
potential
reveal
functional
interplay
between
host
microbes
in
HPV
persistence
progression
cancer.MethodsOur
study
design
included
HPV-negative/positive
controls,
women
low-grade
high-grade
dysplasia,
or
(n
=
78).
Metabolic
fingerprints
were
profiled
using
liquid
chromatography-mass
spectrometry.
Vaginal
analysed
16S
rRNA
gene
sequencing
immunoassays,
respectively.
We
used
an
integrative
bioinformatic
pipeline
microbe
contributions
metabolome
comprehensively
assess
link
HPV,
microbiota,
disease.FindingsMetabolic
analysis
yielded
475
metabolites
known
identities.
Unique
discriminated
patient
groups
from
healthy
controls.
Three-hydroxybutyrate,
eicosenoate,
oleate/vaccenate
(with
excellent
capacity)
patients
versus
participants.
Sphingolipids,
plasmalogens,
linoleate
positively
correlated
inflammation.
Non-Lactobacillus
dominant
communities,
particularly
perturbed
amino
acid
nucleotide
metabolisms.
Adenosine
cytosine
Lactobacillus
abundance
negatively
Glycochenodeoxycholate
carnitine
metabolisms
connected
non-Lactobacillus
dominance
inflammation.InterpretationCervicovaginal
profiles
driven
by
followed
inflammation,
infection,
microbiota.
This
provides
evidence
for
metabolite-driven
complex
host-microbe
interactions
hallmarks
future
translational
potential.FundFlinn
Foundation
(#1974),
Banner
Obstetrics/Gynecology,
NIH
NCI
(P30-CA023074).Graphical
abstract
Cancers,
Journal Year:
2020,
Volume and Issue:
12(11), P. 3244 - 3244
Published: Nov. 3, 2020
Cancer
is
a
complex
disease
that
includes
the
reprogramming
of
metabolic
pathways
by
malignant
proliferating
cells,
including
those
affecting
tumor
microenvironment
(TME).
The
"TME
concept"
was
introduced
in
recognition
roles
played
factors
other
than
cells
cancer
progression.
In
response
to
hypoxic
or
semi-hypoxic
characteristic
TME,
generate
large
amount
lactate
via
metabolism
glucose
and
glutamine.
Export
this
newly
generated
together
with
H+
prevents
intracellular
acidification
but
acidifies
TME.
recent
years,
importance
acidosis
carcinogenesis
has
gained
increasing
attention,
role
as
tumor-promoting
metabolite.
Here
we
review
existing
literature
on
ability
extracellular
direct
cells.
Studies
demonstrating
biological
processes
drive
sustain
(tumor
promotion,
angiogenesis,
metastasis
resistance)
lactate's
an
immunosuppressor
contributes
evasion
are
also
considered.
Finally,
consider
therapeutic
efforts
using
available
drugs
directed
at
interfering
production
transport
treatment.
