Future Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 13(4), P. 335 - 339
Published: Jan. 5, 2021
Language: Английский
Life Sciences, Journal Year: 2020, Volume and Issue: 250, P. 117583 - 117583
Published: March 23, 2020
Language: Английский
Citations
615
Life Sciences, Journal Year: 2020, Volume and Issue: 255, P. 117842 - 117842
Published: May 23, 2020
Language: Английский
Citations
118
Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)
Published: June 2, 2021
Abstract Melatonin is an ancient molecule that evident in high concentrations various tissues throughout the body. It can be separated into two pools; one of which synthesized by pineal and found blood, second present these tissues. Pineal melatonin levels display a circadian rhythm while tissue does not. For decades now, has been implicated promoting maintaining sleep. More recently, evidence indicates it also plays important role neuroprotection. The beginning our review will summarize this literature. As amphiphilic, pleiotropic indoleamine, both direct actions receptor-mediated effects. example, established effects as antioxidant free radical scavenger vitro animal models. This melatonin’s prominent mitochondria, reviewed next section. in, taken up by, concentrated powerhouse cell. Mitochondria are major source reactive oxygen species byproduct mitochondrial oxidative metabolism. final section summarizes potential aging psychiatric disorders. decline with age. declines individuals suffering from Melatonin’s ability to act neuroprotectant opens new avenues exploration for may treatment cases neurodegenerative disease.
Language: Английский
Citations
71
Nutrients, Journal Year: 2021, Volume and Issue: 13(12), P. 4433 - 4433
Published: Dec. 10, 2021
The mechanisms of migraine pathogenesis are not completely clear, but 31P-nuclear magnetic resonance studies revealed brain energy deficit in migraineurs. As glycolysis is the main process production brain, mitochondria may play an important role pathogenesis. Nutrition aspect pathogenesis, as many migraineurs report food-related products triggers. Apart from approved anti-migraine drugs, vitamins and supplements considered prevention therapy, without strong supportive evidence. In this review, we summarize update information about nutrients that be for mitochondrial functions, production, oxidative stress, related to migraine. Additionally, present a brief overview caffeine alcohol, they often reported have ambiguous effects can supplement diet prevent and/or ameliorate riboflavin, thiamine, magnesium ions, niacin, carnitine, coenzyme Q10, melatonin, lipoic acid, pyridoxine, folate, cobalamin. They normal, healthy diet, which should adjusted individual needs determined mainly by physiological constitution organism. intake alcohol fine-tuned history their use, withdrawal these agents regular users become trigger.
Language: Английский
Citations
63
Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 224, P. 107825 - 107825
Published: March 1, 2021
Language: Английский
Citations
61
Life Sciences, Journal Year: 2022, Volume and Issue: 301, P. 120612 - 120612
Published: May 4, 2022
Language: Английский
Citations
53
Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14
Published: June 3, 2022
The concept of “aging” is defined as the set gradual and progressive changes in an organism that leads to increased risk weakness, disease, death. This process may occur at cellular organ level, well entire any living being. During aging, there a decrease biological functions ability adapt metabolic stress. General effects aging include mitochondrial, cellular, organic dysfunction, immune impairment or inflammaging, oxidative stress, cognitive cardiovascular alterations, among others. Therefore, one main harmful consequences development progression multiple diseases related these processes, especially central nervous system levels. Both neurodegenerative pathologies are highly disabling and, many cases, lethal. In this context, melatonin, endogenous compound naturally synthesized not only by pineal gland but also cell types, have key role modulation mechanisms associated with aging. Additionally, indoleamine therapeutic agent, which be administered exogenously high degree safety. For reason, melatonin could become attractive low-cost alternative for slowing processes its diseases, including disorders.
Language: Английский
Citations
42
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 16187 - 16187
Published: Dec. 19, 2022
Anxiety disorders are the most common mental diseases. and associated physical symptoms may disturb social occupational life increase risk of somatic The pathophysiology anxiety development is complex involves alterations in stress hormone production, neurosignaling pathways or free radical production. various manifestations anxiety, its pathophysiological background side effects available treatments underlie quest for constantly seeking therapies these conditions. Melatonin, an indolamine produced pineal gland released into blood on a nightly basis, has been demonstrated to exert anxiolytic action animal experiments different clinical This influences number physiological actions either via specific melatonin receptors by receptor-independent pleiotropic effects. underlying pathomechanism melatonin's benefit reside sympatholytic action, interaction with renin-angiotensin glucocorticoid systems, modulation interneuronal signaling extraordinary antioxidant scavenging nature. Of importance, concentration this significantly higher cerebrospinal fluid than blood. Thus, ensuring sufficient production reducing light pollution, which suppresses levels, represent endogenous neuroprotective treatment. Since freely available, economically undemanding limited effects, it be considered additional alternative treatment conditions anxiety.
Language: Английский
Citations
41
Biology, Journal Year: 2023, Volume and Issue: 12(1), P. 89 - 89
Published: Jan. 6, 2023
Throughout the history of melatonin research, almost exclusive focus has been on nocturnally-generated pineal production, which accounts for its circadian rhythm in blood and cerebrospinal fluid; these light/dark cycles drive daily seasonal photoperiodic alterations organismal physiology. Because is produced secreted primarily at night, it referred to as chemical expression darkness. The importance other sources ignored. Based current evidence, there are least four vertebrates that contribute whole-body pool. These include by (1) gland; (2) extrapineal cells, tissues, organs; (3) microbiota skin, mouth, nose, digestive tract, vagina well (4) present diet. multiple exhibit differentially regulated mechanisms synthesis. Visible light striking retina or an intense physical stimulus can suppress nocturnal levels; contrast, examples where levels increased during heavy exercise daylight, contains whole range NIR radiation. cumulative impact all cells producing augmented sufficient elevate sweat concentrations, potentially, if exposure sustained, also increasing circulating values. transient increases plasma support premise a production capacity exceeds far what be gland, used maintain intercellular homeostasis responds rapid changes ROS density. potential regulatory near infrared (NIR) synthesis discussed detail herein. Combined with discovery high melanopsin most fat their response further calls into question centric theories. While processes related microbiota-derived currently unknown, does seem crosstalk between derived from host originating microbiota.
Language: Английский
Citations
37
Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(4)
Published: March 14, 2023
Language: Английский
Citations
29