Kisspeptin and GnRH interactions in the reproductive brain of teleosts

General and Comparative Endocrinology, Journal Year: 2020, Volume and Issue: 298, P. 113568 - 113568

Published: July 22, 2020

Language: Английский

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Fish reproductive biology – Reflecting on five decades of fundamental and translational research

General and Comparative Endocrinology, Journal Year: 2020, Volume and Issue: 300, P. 113544 - 113544

Published: June 30, 2020

Language: Английский

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Recent advances in understanding gonadotropin signaling

Faculty Reviews, Journal Year: 2021, Volume and Issue: 10

Published: April 19, 2021

Gonadotropins are glycoprotein sex hormones regulating development and reproduction bind to specific G protein–coupled receptors expressed in the gonads. Their effects on multiple signaling cascades intracellular events have recently been characterized using novel technological scientific tools. The impact of allosteric modulators gonadotropin signaling, role sugars linked hormone backbone, detection endosomal compartments supporting modules, dissection different mediated by these molecules areas that advanced significantly last decade. classic view providing exclusive activation cAMP/protein kinase A (PKA) steroidogenic pathway has expanded with addition as determined high-resolution imaging techniques. These new findings provided potential therapeutic applications. Despite improvements, unanswered issues physiology, such intrinsic pro-apoptotic hormones, existence assembled heteromers, their expression extragonadal tissues, remain be studied. Elucidating is a challenge for future research.

Language: Английский

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Cell Communications among Microorganisms, Plants, and Animals: Origin, Evolution, and Interplays

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(21), P. 8052 - 8052

Published: Oct. 28, 2020

Cellular communications play pivotal roles in multi-cellular species, but they do so also uni-cellular species. Moreover, cells communicate with each other not only within the same individual, individuals belonging to or These occur between two unicellular multicellular and The molecular mechanisms involved exhibit diversity specificity, share common basic features, which allow pathways of communication different often phylogenetically very distant. interactions are possible by high degree conservation interaction many ligand–receptor pairs evolutionary remote inter-species cellular played crucial during Evolution must have been positively selected, particularly when collectively beneficial hostile environments. It is likely that did arise after their emergence, were part nature first cells. Synchronization populations non-living protocells through chemical may a mandatory step towards emergence as living explain large commonality cell among microorganisms, plants, animals.

Language: Английский

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Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(12), P. 6478 - 6478

Published: June 17, 2021

From mammals to fish, reproduction is driven by luteinizing hormone (LH) and follicle-stimulating (FSH) temporally secreted from the pituitary gland. Teleost fish are an excellent model for addressing unique regulation function of each gonadotropin cell since, unlike mammals, they synthesize secrete LH FSH distinct cells. Only very distant vertebrate classes (such as birds) demonstrate mono-hormonal strategy, suggesting a potential convergent evolution. Cell-specific transcriptome analysis double-labeled transgenic tilapia expressing GFP RFP in or cells, respectively, yielded genes specifically enriched type, revealing differences regulation, receptor expression, signaling, electrical properties. Each type expresses GPCR signature that reveals direct metabolic homeostatic hormones. Comparing these novel transcriptomes rat gonadotrophs revealed conserved might contribute activity mechanisms controlling differential gonadotropins vertebrates.

Language: Английский

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Neuroendocrine Control of Reproduction in Teleost Fish: Concepts and Controversies

Annual Review of Animal Biosciences, Journal Year: 2021, Volume and Issue: 10(1), P. 107 - 130

Published: Nov. 18, 2021

During the teleost radiation, extensive development of direct innervation mode hypothalamo-pituitary communication was accompanied by loss median eminence typical mammals. Cells secreting follicle-stimulating hormone and luteinizing cells are directly innervated, distinct populations in anterior pituitary. So far, ∼20 stimulatory ∼10 inhibitory neuropeptides, 3 amines, amino acid neurotransmitters implicated control reproduction. Positive negative sex steroid feedback loops operate both sexes. Gene mutation models zebrafish medaka now challenge our general understanding vertebrate neuropeptidergic control. New reproductive neuropeptides emerging. These include but not limited to nesfatin 1, neurokinin B, secretoneurins. A generalized model for neuroendocrine reproduction is proposed. Hopefully, this will serve as a research framework on diverse species help explain evolution lead discovery new hormones with novel applications.

Language: Английский

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Overview and New Insights Into the Diversity, Evolution, Role, and Regulation of Kisspeptins and Their Receptors in Teleost Fish

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: March 22, 2022

In the last two decades, kisspeptin (Kiss) has been identified as an important player in regulation of reproduction and other physiological functions vertebrates, including several fish species. To date, ligands (Kiss1, Kiss2) three receptors (Kissr1, Kissr2, Kissr3) have teleosts, likely due to whole-genome duplication loss genes that occurred early teleost evolution. Recent results zebrafish medaka mutants challenged notion system is essential for fish, marked contrast situation mammals. this context, review focuses on role kisspeptins at levels reproductive, brain-pituitary-gonadal (BPG) axis fish. addition, compiled information factors controlling Kiss/Kissr system, such photoperiod, temperature, nutritional status, sex steroids, neuropeptides, others. article, we summarize available molecular diversity evolution, tissue expression neuroanatomical distribution, functional significance, signaling pathways, gene Kiss Kissr fishes. Of particular note are recent advances understanding flatfish systems, which require further study reveal their structural diversity.

Language: Английский

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Anomalous Temperature Interdicts the Reproductive Activity in Fish: Neuroendocrine Mechanisms of Reproductive Function in Response to Water Temperature

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: May 24, 2022

Fish are poikilotherm and small changes in water temperature can greatly affect physiological processes including reproduction, which is regulated by complex neuroendocrine mechanisms that respond to climatic events. This review provides evidence anomalous high low may directly reproduction fish suppressing the expression of genes reproductive system. The grass puffer, Takifugu alboplumbeus , an excellent animal model for studying thermal regulation they exhibit periodic spawning activities, synchronized with seasonal, lunar daily cycles. In encoding gonadotropin-releasing hormone (GnRH) 1, kisspeptin, gonadotropin-inhibitory (GnIH) their receptors were markedly suppressed diencephalon exposed (28°C) when compared normal (21°C), followed decrease pituitary mRNA levels follicle-stimulating (FSH), luteinizing (LH) growth (GH). On other hand, exposure (14°C) also inhibited gnrh1, kiss2, gnih receptor brain fshb lhb gh prl pituitary. Taken together, it plausible be a proximate driver termination activity GnRH/kisspeptin/GnIH system, possibly through direct action signals at transcription level.

Language: Английский

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CRISPR-Cas9 gene-editing to assess the role of RF-amide related peptide 3 in ovine seasonal breeding

animal, Journal Year: 2025, Volume and Issue: 19(5), P. 101508 - 101508

Published: April 5, 2025

Seasonal breeding is an adaptive strategy that ensures the birth of offspring during best time year and allows energy saving in times food scarcity adverse environmental conditions. At temperate polar latitudes, photoperiod main synchroniser seasonal functions, which exerts its action through melatonin. Within pars tuberalis anterior pituitary, melatonin triggers a series events lead to enhanced local triiodothyronine (T3) production medio-basal hypothalamus specifically under long days ultimately drive appropriate GnRH output at median eminence. How T3 governs mostly unknown but neuronal populations respectively produce KISS1 RFRP3 appear be involved. However, while role as major secretagogue undisputed, function control (seasonal) remains enigmatic, with conflicting results hinting elusive mechanisms. Therefore, we launched extensive experiments sheep, aimed invalidating NPVF gene, encodes RFRP3, using CRISPR-Cas9 technology. Here, report on generation six sheep for gene has been successfully edited. Four these animals bear least one allele expected behave null constitute founders distinct ovine lines. These founder will now enter standard scheme order obtain male female homozygotes mutations. are provide clear delineation breeding.

Language: Английский

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Evolution of the GnRH Neuron

Masterclass in neuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 143 - 164

Published: Jan. 1, 2025

Language: Английский

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