Moving towards a connectomic view of neuro-oncology

The Lancet Neurology, Journal Year: 2024, Volume and Issue: 23(7), P. 655 - 656

Published: June 13, 2024

Language: Английский

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The inferior fronto-occipital fascicle: a century of controversies from anatomy theaters to operative neurosurgery

Journal of Neurosurgical Sciences, Journal Year: 2022, Volume and Issue: 65(6)

Published: Jan. 21, 2022

Since its first description in the early 19th century, inferior fronto-occipital fascicle (IFOF) and anatomo-functional features were neglected neuroscientific literature for last century. In decade, rapid development of in-vivo imaging reconstruction white matter (WM) connectivity (i.e., tractography) consequent interest more traditional ex vivo methods (post-mortem dissection) have allowed a renewed debate about course, termination territories, anatomical relationships, functional roles this fascicle. We reviewed main current knowledge concerning structural anatomy IFOF possible implications neurosurgical practice. The connects occipital cortex, temporo-basal areas, superior parietal lobule, precuneus to frontal lobe, passing through ventral third subinsular WM external capsule. This wide distribution cortical terminations provides multimodal integration between several networks, including language, non-verbal semantic processing, object identification, visuo-spatial processing planning, reading, facial expression recognition, memory conceptualization, emotional neuropsychological behavior. organization has important implication also practice, especially when approaching frontal, insular, temporo-parieto-occipital regions ventricular system. conclusion, is most extensive associative bundle human connectome. Its multi-layer reflects many aspects brain processing. Accurate awareness datasets coming from different sources crucial both quality treatments.

Language: Английский

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Constant Multi-Tasking With Time Constraint to Preserve Across-Network Dynamics Throughout Awake Surgery for Low-Grade Glioma: A Necessary Step to Enable Patients Resuming an Active Life

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: May 26, 2022

Awake surgery for brain gliomas improves resection while minimizing morbidity. Although intraoperative mapping was originally used to preserve motor and language functions, the considerable increase of life expectancy, especially in low-grade glioma, resulted need enhance patients' long-term quality life. If main goal awake is resume normal familial socio-professional activities, preventing hemiparesis aphasia not sufficient: cognitive emotional functions must be considered. To monitor higher-order e.g., executive control, semantics or mentalizing, further tasks were implemented into operating theater. Beyond this more accurate investigation function-specific neural networks, a better exploration inter-system communication required. Advances connectomics led meta-network perspective processing, which emphasizes pivotal role dynamic interplay between functional circuits allow complex flexible, goal-directed behaviors. Constant multi-tasking with time constraint patients may proposed during mapping, since it provides mirror (dys)synchronization within across networks sensitivity behavioral monitoring by increasing demand throughout resection. Electrical hamper patient perform several simultaneously whereas he/she still capable achieve each task isolation. Unveiling organization using ecological multi-demand testing, representative real-life conditions, constitutes reliable way tailor surgical onco-functional balance based upon expectations patient, enabling him/her an active long-lasting projects.

Language: Английский

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The Concept of «Peritumoral Zone» in Diffuse Low-Grade Gliomas: Oncological and Functional Implications for a Connectome-Guided Therapeutic Attitude

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(4), P. 504 - 504

Published: April 15, 2022

Diffuse low-grade gliomas (DLGGs) are heterogeneous and poorly circumscribed neoplasms with isolated tumor cells that extend beyond the margins of lesion depicted on MRI. Efforts to demarcate glioma core from surrounding healthy brain led us define an intermediate region, so-called peritumoral zone (PTZ). Although most studies about PTZ have been conducted high-grade gliomas, purpose here is review cellular, metabolic, radiological characteristics in specific context DLGG. A better delineation PTZ, which neural tissue strongly interact, may open new therapeutic avenues optimize both functional oncological results. First, a connectome-based “supratotal” surgical resection (i.e., removal addition core) resulted prolonged survival by limiting risk malignant transformation, while improving quality life, thanks control seizures. Second, timing order (neo)adjuvant medical treatments can be modulated according pattern infiltration. Third, development drugs specifically targeting could considered (such as immunotherapy) epileptological perspective. Further multimodal investigations needed maximize long-term outcomes DLGG patients.

Language: Английский

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Dynamic network reorganization underlying neuroplasticity: the deficits-severity-related language network dynamics in patients with left hemispheric gliomas involving language network

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(13), P. 8273 - 8285

Published: April 1, 2023

Brain network dynamics not only endow the brain with flexible coordination for various cognitive processes but also a huge potential of neuroplasticity development, skill learning, and after cerebral injury. Diffusive progressive glioma infiltration triggers functional compensation, which is an outstanding pathophysiological model investigation reorganization underlying neuroplasticity. In this study, we employed dynamic conditional correlation to construct framewise language networks investigated reorganizations in 83 patients left hemispheric gliomas involving (40 without aphasia 43 aphasia). We found that, healthy controls (HCs) patients, resting state clustered into 4 temporal-reoccurring states. Language deficits-severity-dependent topological abnormalities dFCs were observed. Compared HCs, suboptimal observed those aphasia, while more severe disruptions aphasia. Machine learning-based dFC-linguistics prediction analyses showed that states significantly predicted individual patients' scores. These findings shed light on our understanding metaplasticity glioma. Glioma-induced under "meta-networking" (network networks) framework. glioma, resting-state robustly The spatial temporal network.

Language: Английский

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