Immunity, Journal Year: 2020, Volume and Issue: 52(5), P. 767 - 781.e6
Published: April 10, 2020
Language: Английский
Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(41)
Published: Sept. 25, 2017
Significance Cell volume is thought to be a well-controlled cellular characteristic, increasing as cell grows, while macromolecular density maintained. We report that can also change in response external physical cues, leading water influx/efflux, which causes significant changes subcellular density. This observed when cells spread out on substrate: Cells reduce their and increase molecular crowding due an accompanying efflux. Exploring this phenomenon further, we removed from mesenchymal stem through osmotic pressure found was sufficient alter differentiation pathway. Based these results, suggest chart different behavioral pathways by sensing/altering cytoplasmic influx/efflux.
Language: Английский
Citations
471
Trends in Molecular Medicine, Journal Year: 2010, Volume and Issue: 16(3), P. 107 - 121
Published: Feb. 17, 2010
Language: Английский
Citations
404
Physiological Reviews, Journal Year: 2012, Volume and Issue: 92(4), P. 1865 - 1913
Published: Oct. 1, 2012
Cell motility is central to tissue homeostasis in health and disease, there hardly any cell the body that not motile at a given point its life cycle. Important physiological processes intimately related ability of respective cells migrate include embryogenesis, immune defense, angiogenesis, wound healing. On other side, migration associated with life-threatening pathologies such as tumor metastases atherosclerosis. Research from last ∼15 years revealed ion channels transporters are indispensable components cellular apparatus. After presenting general principles by which transport proteins affect migration, we will discuss systematically role involved migration.
Language: Английский
Citations
387
Immunity, Journal Year: 2012, Volume and Issue: 37(3), P. 487 - 500
Published: Sept. 1, 2012
Language: Английский
Citations
370
Physiological Reviews, Journal Year: 2018, Volume and Issue: 98(2), P. 559 - 621
Published: Feb. 7, 2018
Genomic instability is a primary cause and fundamental feature of human cancer. However, all cancer cell genotypes generally translate into several common pathophysiological features, often referred to as hallmarks. Although nowadays the catalog hallmarks quite broad, most obvious them are 1) uncontrolled proliferation, 2) resistance programmed death (apoptosis), 3) tissue invasion metastasis, 4) sustained angiogenesis. Among genes affected by cancer, those encoding ion channels present. Membrane proteins responsible for signaling within among cells, coupling extracellular events with intracellular responses, maintaining ionic homeostasis contribute various extents features each hallmark. Moreover, tight association these channel dysfunction gives good reason classify special type channelopathies, namely oncochannelopathies. relation differs from classical definition disease states causally linked inherited mutations that alter channel's biophysical properties, in broader context state, which pathogenesis essentially contribute, such classification seems absolutely appropriate. In this review authors provide arguments substantiate point view.
Language: Английский
Citations
366
Nature, Journal Year: 2013, Volume and Issue: 495(7441), P. 375 - 378
Published: March 1, 2013
Language: Английский
Citations
362
Physiological Reviews, Journal Year: 2012, Volume and Issue: 92(1), P. 39 - 74
Published: Jan. 1, 2012
Fluid and HCO 3 − secretion is a vital function of all epithelia required for the survival tissue. Aberrant fluid associated with many epithelial diseases, such as cystic fibrosis, pancreatitis, Sjögren's syndrome, other inflammatory autoimmune diseases. Significant progress has been made over last 20 years in our understanding secretion, particular by secretory glands. glands two-step process. Acinar cells secrete isotonic which major salt NaCl. Subsequently, duct modifies volume electrolyte composition to absorb Cl . The relative secreted acinar modification fluids varies among meet their physiological functions. In pancreas, small amount NaCl-rich fluid, while absorbs secretes bulk pancreatic juice. appears be driven active secretion. salivary glands, saliva that contains high concentrations Na + both K this review, we focus on molecular mechanism pancreas highlight similarities fundamental mechanisms cell functions, point out differences gland-specific secretions.
Language: Английский
Citations
340
PLoS Pathogens, Journal Year: 2011, Volume and Issue: 7(7), P. e1002124 - e1002124
Published: July 14, 2011
Viruses rely on the metabolic network of host cell to provide energy and macromolecular precursors fuel viral replication. Here we used mass spectrometry examine impact two related herpesviruses, human cytomegalovirus (HCMV) herpes simplex virus type-1 (HSV-1), metabolism fibroblast epithelial cells. Each triggered strong changes that were conserved across different types. The effects viruses were, however, largely distinct. HCMV but not HSV-1 increased glycolytic flux. profoundly TCA compound levels flow carbon units required for cycle turning fatty acid synthesis. anapleurotic influx through pyruvate carboxylase, feeding pyrimidine biosynthesis. Thus, these herpesviruses drive diverse cells execute distinct, virus-specific programs. Current drugs target nucleotide treatment both viruses. Although our results confirm this is a robust HSV-1, therapeutic interventions at other points in might prove more effective HCMV.
Language: Английский
Citations
331
Science Signaling, Journal Year: 2010, Volume and Issue: 3(104)
Published: Jan. 12, 2010
Responses to ATP play an important role in regulating the signaling and function of a diverse array cells tissues.
Language: Английский
Citations
326
Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(7), P. 495 - 516
Published: Feb. 27, 2023
Language: Английский
Citations
326