VRACs and other ion channels and transporters in the regulation of cell volume and beyond

Nature Reviews Molecular Cell Biology, Journal Year: 2016, Volume and Issue: 17(5), P. 293 - 307

Published: April 1, 2016

Language: Английский

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Physiological role of taurine – from organism to organelle

Acta Physiologica, Journal Year: 2014, Volume and Issue: 213(1), P. 191 - 212

Published: Aug. 20, 2014

Taurine is often referred to as a semi-essential amino acid newborn mammals have limited ability synthesize taurine and rely on dietary supply. not thought be incorporated into proteins no aminoacyl tRNA synthetase has yet been identified oxidized in mammalian cells. However, contributes significantly the cellular pool of organic osmolytes accordingly acknowledged for its role cell volume restoration following osmotic perturbation. This review describes homeostasis cells organelles with emphasis biophysics/membrane dynamics, regulation transport involved active uptake passive release well physiological processes, example, development, lung function, mitochondrial antioxidative defence apoptosis which seem affected by shift expression transporters and/or content.

Language: Английский

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Human aquaporins: Regulators of transcellular water flow

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2013, Volume and Issue: 1840(5), P. 1492 - 1506

Published: Sept. 30, 2013

Emerging evidence supports the view that (AQP) aquaporin water channels are regulators of transcellular flow. Consistent with their expression in most tissues, AQPs associated diverse physiological and pathophysiological processes.AQP knockout studies suggest regulatory role AQPs, rather than action as passive channels, is critical function. Transport through all occurs by a common mechanism, but regulation cellular distribution varies significantly depending on cell tissue type; volume (CVR) particularly notable. This review examines flow, especially CVR. We focus key systems human body, encompassing processes urine concentration kidney to clearance brain oedema.AQPs crucial for homeostasis, providing selective pores rapid movement across membranes playing roles Gating mechanisms have been proposed only reported plant microbial AQPs. Consequently, it likely abundance particular membrane determinant permeability regulator flow.Elucidating regulate flow will improve our understanding body health disease. The central specific regulating homeostasis provide routes range novel therapies. article part Special Issue entitled Aquaporins.

Language: Английский

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LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength

Cell, Journal Year: 2016, Volume and Issue: 164(3), P. 499 - 511

Published: Jan. 1, 2016

Language: Английский

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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

Immunity, Journal Year: 2020, Volume and Issue: 52(5), P. 767 - 781.e6

Published: April 10, 2020

Language: Английский

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