Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
12, P. 246 - 256
Published: Oct. 25, 2021
Pathogenic
bacteria
pose
a
devastating
threat
to
public
health.
However,
because
of
the
growing
bacterial
antibiotic
resistance,
there
is
an
urgent
need
develop
alternative
antibacterial
strategies
established
antibiotics.
Herein,
iron-doped
carbon
dots
(Fe-CDs,
∼3
nm)
nanozymes
with
excellent
photothermal
conversion
and
photoenhanced
enzyme-like
properties
are
developed
through
facile
one-pot
pyrolysis
approach
for
synergistic
efficient
therapy
wound
healing.
In
particular,
Fe
doping
endows
CDs
peroxidase
(POD)-like
activity,
which
lead
generation
heat
reactive
oxygen
species
(ROS)
Gram-positive
Gram-negative
killing.
This
study
demonstrates
Fe-CDs
have
significant
healing
efficiency
by
preventing
infection,
promoting
fibroblast
proliferation,
angiogenesis,
collagen
deposition.
Furthermore,
ultrasmall
size
possesses
good
biocompatibility
favoring
clinical
translation.
We
believe
that
nanozyme-mediated
therapeutic
platform
presented
here
expected
show
promising
applications
in
antibacterial.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(30), P. 34455 - 34469
Published: July 20, 2022
Engineered
wound
dressing
materials
with
excellent
injectability,
self-healing
ability,
tissue-adhesiveness,
especially
the
ones
possessing
potential
therapeutic
effects
have
great
practical
significance
in
healthcare.
Herein,
an
injectable
quaternary
ammonium
chitosan
(QCS)/tannic
acid
(TA)
hydrogel
based
on
QCS
and
TA
was
designed
fabricated
by
facile
mixing
of
two
ingredients
under
physiological
conditions.
In
this
system,
hydrogels
were
mainly
cross-linked
dynamic
ionic
bonds
hydrogen
between
TA,
which
endows
injectable,
self-healing,
adhesive
properties.
Benefitting
from
inherent
antioxidative,
antibacterial,
hemostatic
abilities
QCS,
showed
superior
reactive
oxygen
species
scavenging
activity,
broad-spectrum
antibacterial
as
well
rapid
capability.
Moreover,
QCS/TA2.5
(containing
2.5%
TA)
exhibited
biocompatibility.
The
vivo
experiments
also
that
not
only
rapidly
stopped
bleeding
arterial
deep
incompressible
wounds
mouse
tail
amputation,
femoral
artery
hemorrhage,
liver
incision
models
but
significantly
accelerated
healing
a
full-thickness
skin
model.
For
potentials
listed
above,
multifunctional
offers
promising
network
material
for
both
hemostasis
repair.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(16), P. 4917 - 4917
Published: Aug. 13, 2021
Macrophages
play
a
prominent
role
in
wound
healing.
In
the
early
stages,
they
promote
inflammation
and
remove
pathogens,
debris,
cells
that
have
apoptosed.
Later
repair
process,
dampen
secrete
factors
regulate
proliferation,
differentiation,
migration
of
keratinocytes,
fibroblasts,
endothelial
cells,
leading
to
neovascularisation
closure.
The
macrophages
coordinate
this
process
are
complex:
originate
from
different
sources
distinct
phenotypes
with
diverse
functions
act
at
various
times
process.
individuals
diabetes
altered,
displaying
hyperresponsiveness
inflammatory
stimulants
increased
secretion
pro-inflammatory
cytokines.
They
also
reduced
ability
phagocytose
pathogens
efferocytose
undergone
apoptosis.
This
leads
capacity
and,
as
efferocytosis
is
trigger
for
their
phenotypic
switch,
it
reduces
number
M2
reparative
wound.
can
lead
diabetic
foot
ulcers
(DFUs)
forming
contributes
risk
not
healing
becoming
infected,
potentially,
amputation.
Understanding
macrophage
dysregulation
DFUs
how
these
might
be
along
associated
inflammation,
will
ultimately
allow
better
therapies
complement
current
treatment
increase
DFU's
rates.
Frontiers in Oncology,
Journal Year:
2019,
Volume and Issue:
9
Published: Dec. 11, 2019
During
carcinogenesis,
advanced
tumors
are
surrounded
by
both
stromal
and
immune
cells,
which
support
tumor
development.
In
addition,
inflammation
angiogenesis
processes
that
play
important
roles
in
the
development
of
cancer,
from
initiation
situ
stages
cancer.
acute
inflammation,
vascular
hyperpermeability
allows
inflammatory
mediators
response
including
leukocytes
monocytes/macrophages,
to
infiltrate
site
damage.
As
a
factor
regulates
permeability,
endothelial
growth
(VEGF)
also
plays
vital
role
as
multifunctional
molecule
factor.
Furthermore,
cells
secrete
soluble
factors
activate
favor
their
transmigration
eliminate
aggressive
agent.
this
review,
we
present
comprehensive
view
relationship
between
chronic
during
carcinogenesis
participation
process.
regulatory
mechanisms
contribute
endothelium
returning
its
basal
permeability
state
after
discussed.
Moreover,
manner
participate
pathological
release
pro-angiogenic
early
vascularization,
even
before
angiogenic
switch
occurs,
is
examined.
Also,
discuss
hypoxia
mechanism
drives
acquisition
hallmarks
make
certain
cancers
more
aggressive.
Finally,
some
combinations
therapies
inhibit
process
may
be
successful
strategy
for
cancer
patients
indicated.
Cells,
Journal Year:
2022,
Volume and Issue:
11(15), P. 2439 - 2439
Published: Aug. 6, 2022
Wound
healing
is
highly
specialized
dynamic
multiple
phase
process
for
the
repair
of
damaged/injured
tissues
through
an
intricate
mechanism.
Any
failure
in
normal
wound
results
abnormal
scar
formation,
and
chronic
state
which
more
susceptible
to
infections.
Chronic
wounds
affect
patients'
quality
life
along
with
increased
morbidity
mortality
are
huge
financial
burden
healthcare
systems
worldwide,
thus
requires
biomedical
intensive
treatment
its
management.
The
clinical
assessment
management
remains
challenging
despite
development
various
therapeutic
regimens
owing
painstakingly
long-term
requirement
complex
Various
conventional
approaches
such
as
cell
therapy,
gene
growth
factor
delivery,
dressings,
skin
grafts
etc.,
being
utilized
promoting
different
types
wounds.
However,
all
these
abovementioned
therapies
not
satisfactory
types,
therefore,
there
urgent
demand
competitive
therapies.
Therefore,
a
pertinent
develop
newer
innovative
modalities
multipart
Recent
developments
advanced
care
technology
includes
nanotherapeutics,
stem
cells
bioengineered
grafts,
3D
bioprinting-based
strategies
improving
outcomes
focus
on
regeneration
minimal
side
effects.
main
objective
this
review
provide
updated
overview
progress
options
over
years
using
next
generation
approaches.
Herein,
we
have
discussed
function
anatomy,
processes,
followed
by
regeneration.
Furthermore,
emerging
bioprinted
skin,
extracellular
matrix-based
approaches,
platelet-rich
plasma-based
cold
plasma
therapy
been
their
benefits
shortcomings.
Finally,
challenges
reviewed
note
future
prospects.
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: Dec. 4, 2020
The
underlying
mechanisms
of
wound
healing
are
complex
but
inflammation
is
one
the
determining
factors.
Besides
its
traditional
role
in
combating
against
infection
upon
injury,
characteristics
and
magnitude
have
dramatic
impacts
on
pathogenesis
scar.
Keloids
hypertrophic
scars
pathological
that
result
from
aberrant
healing.
They
characterized
by
continuous
local
excessive
collagen
deposition.
In
this
review,
we
aim
at
discussing
how
dysregulated
contributes
to
scar
formation.
Immune
cells,
soluble
inflammatory
mediators,
related
intracellular
signal
transduction
pathways
our
three
subtopics
encompassing
events
occurring
associated
with
end,
enumerate
current
potential
medicines
therapeutics
for
suppressing
limiting
progression
Understanding
initiation,
progression,
resolution
will
provide
insights
into
formation
useful
developing
effective
treatments.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(10)
Published: Feb. 9, 2022
Skin
wound
repair
is
a
multistage
process
involving
multiple
cellular
and
molecular
interactions,
which
modulate
the
cell
behaviors
dynamic
remodeling
of
extracellular
matrices
to
maximize
regeneration
repair.
Consequently,
abnormalities
in
functions
or
pathways
inevitably
give
rise
side
effects,
such
as
dysregulated
inflammation,
hyperplasia
nonmigratory
epithelial
cells,
lack
response
growth
factors,
impedes
angiogenesis
fibrosis.
These
issues
may
cause
delayed
healing
even
non-healing
states.
Current
clinical
therapeutic
approaches
are
predominantly
dedicated
preventing
infections
alleviating
topical
symptoms
rather
than
addressing
modulation
microenvironments
achieve
targeted
outcomes.
Bioactive
materials,
relying
on
their
chemical,
physical,
biological
properties
carriers
bioactive
substances,
can
affect
promote
at
level.
By
mechanisms
from
perspective
behaviors,
this
review
discusses
how
materials
within
wounds
during
stages
hemostasis,
anti-inflammation,
tissue
deposition,
matrix
remodeling.
A
deeper
understanding
bound
development
more
efficient
for
applications.
