Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system DOI Creative Commons
Pizga Kumwenda, Fabien Cottier, Alex C. Hendry

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 38(1), P. 110183 - 110183

Published: Jan. 1, 2022

Candida albicans is a commensal of the urogenital tract and predominant cause vulvovaginal candidiasis (VVC). Factors that increase circulatory estrogen levels such as pregnancy, use oral contraceptives, hormone replacement therapy predispose women to VVC, but reasons for this are largely unknown. Here, we investigate how adaptation C. impacts fungal host-pathogen interaction. Estrogen promotes virulence by enabling avoid actions innate immune system. Estrogen-induced evasion mediated via inhibition opsonophagocytosis through enhanced acquisition human complement regulatory protein, Factor H, on cell surface. accumulation H dependent surface protein Gpd2. The discovery hormone-sensing pathway might pave way in explaining gender biases associated with infections may provide an alternative approach improving women's health.

Language: Английский

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection DOI Open Access
Rudragouda Channappanavar,

Craig Fett,

Matthias Mack

et al.

The Journal of Immunology, Journal Year: 2017, Volume and Issue: 198(10), P. 4046 - 4053

Published: April 4, 2017

Abstract Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and Middle East syndrome–CoV, cause illness. Epidemiological data from 2002–2003 SARS epidemic recent outbreak indicate that there may be sex-dependent differences in disease outcomes. To investigate these differences, we infected male female mice of different age groups with SARS-CoV analyzed their susceptibility to infection. Our results showed were more susceptible infection compared age-matched females. The degree sex bias increased advancing age, middle-aged much pronounced young mice. Enhanced was associated elevated virus titers, enhanced vascular leakage, alveolar edema. These changes accompanied by accumulation inflammatory monocyte macrophages neutrophils lungs mice, depletion partially protected lethal SARS. Moreover, sex-specific independent T B cell responses. Furthermore, ovariectomy or treating an estrogen receptor antagonist mortality, indicating a protective effect for signaling SARS-CoV. Together, suggest parallel those observed patients also identify critical protection

Language: Английский

Citations

896
Sex-based differences in immune function and responses to vaccination DOI Open Access
Sabra L. Klein, Ian Marriott, Eleanor N. Fish

et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, Journal Year: 2015, Volume and Issue: 109(1), P. 9 - 15

Published: Jan. 1, 2015

Females typically develop higher antibody responses and experience more adverse reactions following vaccination than males. These differences are observed in response to diverse vaccines, including the bacillus Calmette-Guerin vaccine, measles, mumps rubella yellow fever virus vaccine influenza vaccines. Sex vaccines across age groups, ranging from infants aged individuals. Biological as well behavioral between sexes likely contribute outcome of sexes. Immunological, hormonal, genetic microbiota males females may also affect vaccination. Identifying ways reduce increase immune will be necessary adequately protect both against infectious diseases.

Language: Английский

Citations

493
Sex Hormones Determine Immune Response DOI Creative Commons
Veena Taneja

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: Aug. 27, 2018

OPINION article Front. Immunol., 27 August 2018Sec. Cytokines and Soluble Mediators in Immunity Volume 9 - 2018 | https://doi.org/10.3389/fimmu.2018.01931

Language: Английский

Citations

493
Sex differences in vaccine-induced humoral immunity DOI Creative Commons
Stephanie Fischinger, Carolyn M. Boudreau,

Audrey L. Butler

et al.

Seminars in Immunopathology, Journal Year: 2018, Volume and Issue: 41(2), P. 239 - 249

Published: Dec. 13, 2018

Vaccines are among the most impactful public health interventions, preventing millions of new infections and deaths annually worldwide. However, emerging data suggest that vaccines may not protect all populations equally. Specifically, studies analyzing variation in vaccine-induced immunity have pointed to critical impact genetics, environment, nutrition, microbiome, sex influencing vaccine responsiveness. The significant contribution modulating has gained attention over last years. females typically develop higher antibody responses experience more adverse events following vaccination than males. This enhanced immune reactogenicity is thought render resistant infectious diseases, but conversely also contribute incidence autoimmunity women. Dissection mechanisms which underlie differences implicated hormonal, genetic, microbiota across males females. review will highlight importance sex-dependent specifically address role as a modulator humoral immunity, key long-term pathogen-specific protection.

Language: Английский

Citations

362
SeXX matters in immunity DOI
Janet Markle, Eleanor N. Fish

Trends in Immunology, Journal Year: 2013, Volume and Issue: 35(3), P. 97 - 104

Published: Nov. 13, 2013

Language: Английский

Citations

326
The impact of the gut microbiota on the reproductive and metabolic endocrine system DOI Creative Commons
Xinyu Qi, Chuyu Yun, Yanli Pang

et al.

Gut Microbes, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 1, 2021

As the gut microbiota exerts various effects on intestinal milieu which influences distant organs and pathways, it is considered to be a full-fledged endocrine organ. The plays major role in reproductive system throughout woman's lifetime by interacting with estrogen, androgens, insulin, other hormones. Imbalance of composition can lead several diseases conditions, such as pregnancy complications, adverse outcomes, polycystic ovary syndrome (PCOS), endometriosis, cancer; however, research mechanisms limited. More effort should concentrated exploring potential causes underlying microbiota-hormone-mediated disease, providing novel therapeutic preventive strategies.As strategies.

Language: Английский

Citations

324
Infant antibiotic exposure and the development of childhood overweight and central adiposity DOI Open Access
Meghan B. Azad, Sarah L. Bridgman, Allan B. Becker

et al.

International Journal of Obesity, Journal Year: 2014, Volume and Issue: 38(10), P. 1290 - 1298

Published: July 11, 2014

Language: Английский

Citations

310
The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms DOI Open Access
Robyn Meech, Dong Hu, Ross A. McKinnon

et al.

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(2), P. 1153 - 1222

Published: Feb. 6, 2019

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range lipophilic molecules. This biotransformation plays critical role in elimination exogenous chemicals and by-products endogenous metabolism, also controls levels distribution many signaling In mammals, superfamily comprises four families: UGT1, UGT2, UGT3, UGT8. UGT1 UGT2 enzymes have important roles pharmacology toxicology including contributing interindividual differences drug disposition as well cancer risk. These UGTs are highly expressed organs detoxification (e.g., liver, kidney, intestine) can be induced by pathways that sense demand for modulation endobiotic The functions UGT3 UGT8 family only been characterized relatively recently; these show different UDP-sugar preferences enzymes, date, their contributions metabolism appear minor. review summarizes provides analysis current state research into all families UGT enzymes. Key areas discussed include risk, regulation signaling, transcriptional posttranscriptional control expression function. latter part this an in-depth known predicted focused on likely pathways.

Language: Английский

Citations

274
Gut microbial molecules in behavioural and neurodegenerative conditions DOI
Brittany D. Needham, Rima Kaddurah‐Daouk, Sarkis K. Mazmanian

et al.

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(12), P. 717 - 731

Published: Oct. 16, 2020

Language: Английский

Citations

274
Sex hormones in the modulation of irritable bowel syndrome DOI Creative Commons
Agata Mulak, Yvette Taché, Muriel Larauche

et al.

World Journal of Gastroenterology, Journal Year: 2014, Volume and Issue: 20(10), P. 2433 - 2433

Published: Jan. 1, 2014

Compelling evidence indicates sex and gender differences in epidemiology, symptomatology, pathophysiology, treatment outcome irritable bowel syndrome (IBS).Based on the female predominance as well correlation between IBS symptoms hormonal status, several models have been proposed to examine role of hormones gastrointestinal (GI) function including GI expression distinct phases menstrual cycle, pre-and post-menopausal women, during pregnancy, or after oophorectomy.Sex may influence peripheral central regulatory mechanisms brain-gut axis involved pathophysiology contributing alterations visceral sensitivity, motility, intestinal barrier function, immune activation mucosa.Sex stress response hypothalamic-pituitary-adrenal autonomic nervous system, neuroimmune interac-tions triggered by stress, estrogen interactions with serotonin corticotropin-releasing factor signaling systems are being increasingly recognized.A concept "microgenderome" related potential hormone modulation gut microbiota is also emerging.Significant male patients regarding symptomatology comorbidity other chronic pain syndromes psychiatric disorders, together efficacy serotonergic medications confirm necessity for more sex-tailored therapeutic approach this disorder.

Language: Английский

Citations

230