Cell Reports,
Journal Year:
2022,
Volume and Issue:
38(1), P. 110183 - 110183
Published: Jan. 1, 2022
Candida
albicans
is
a
commensal
of
the
urogenital
tract
and
predominant
cause
vulvovaginal
candidiasis
(VVC).
Factors
that
increase
circulatory
estrogen
levels
such
as
pregnancy,
use
oral
contraceptives,
hormone
replacement
therapy
predispose
women
to
VVC,
but
reasons
for
this
are
largely
unknown.
Here,
we
investigate
how
adaptation
C.
impacts
fungal
host-pathogen
interaction.
Estrogen
promotes
virulence
by
enabling
avoid
actions
innate
immune
system.
Estrogen-induced
evasion
mediated
via
inhibition
opsonophagocytosis
through
enhanced
acquisition
human
complement
regulatory
protein,
Factor
H,
on
cell
surface.
accumulation
H
dependent
surface
protein
Gpd2.
The
discovery
hormone-sensing
pathway
might
pave
way
in
explaining
gender
biases
associated
with
infections
may
provide
an
alternative
approach
improving
women's
health.
Biology of Sex Differences,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: June 20, 2018
Sex
differences
are
important
epidemiological
factors
that
impact
in
the
frequency
and
severity
of
infectious
diseases.
A
clear
sexual
dimorphism
bacterial
infections
has
been
reported
both
humans
animal
models.
Nevertheless,
molecular
mechanisms
involved
this
gender
bias
just
starting
to
be
elucidated.
In
present
article,
we
aim
review
available
data
literature
report
presenting
a
dimorphism,
without
considering
behavioral
social
factors.The
mainly
attributed
differential
levels
sex
hormones
between
males
females,
as
well
genetic
factors.
general,
more
susceptible
gastrointestinal
respiratory
diseases
sepsis,
while
females
genitourinary
tract
infections.
However,
these
incidences
depend
on
population
evaluated,
model
species.
Female
protection
against
associated
complications
is
assumed
due
pro-inflammatory
effect
estradiol,
male
susceptibility
those
with
testosterone-mediated
immune
suppression,
probably
via
their
specific
receptors.
Recent
studies
indicate
protective
estradiol
depends
estrogen
receptor
subtype
tissue
compartment
insult,
suggesting
tissue-specific
expression
particular
steroid
receptors
contributes
Furthermore,
also
effects
Finally,
since
large
number
genes
related
functions
located
X
chromosome,
X-linked
mosaicism
confers
highly
polymorphic
gene
program
allows
women
respond
expanded
repertoire
compared
men.Notwithstanding
there
increasing
evidence
confirms
certain
associated,
further
required
clarify
conflicting
determine
role
hormone
infections,
potential
therapeutic
targets.
Microbiome,
Journal Year:
2018,
Volume and Issue:
6(1)
Published: Feb. 6, 2018
Gut
microbiota
provide
functions
of
importance
to
influence
hosts'
food
digestion,
metabolism,
and
protection
against
pathogens.
Factors
that
affect
the
composition
gut
microbial
communities
are
well
studied
in
humans
other
animals;
however,
we
have
limited
knowledge
how
natural
web
factors
such
as
stress
from
predators
resource
rations
could
it
interacts
with
host
sex.
In
this
study,
designed
a
two-factorial
experiment
exposing
perch
(Perca
fluviatilis)
predator
(pike,
Esox
lucius),
different
ratios,
examine
compositional
functional
changes
based
on
16S
rRNA
amplicon
sequencing.
We
also
investigated
if
those
sex
dependent.We
showed
overall
among
individual
significantly
responded
ration
presence.
found
species
richness
decreased
presence,
identified
23
taxa
diverse
set
phyla
were
over-represented
when
was
present.
For
example,
Fusobacteria
increased
both
at
lowest
predation
conditions,
suggesting
favored
by
stressful
situations
for
host.
concordance,
seemed
metabolic
repertoire
microbiota,
biosynthesis
secondary
metabolites,
metabolism
cofactors,
vitamins.
addition,
interaction
between
emphasizes
sex-specific
responses
diet
quantity
microbiota.Collectively,
our
findings
emphasize
an
alternative
state
webs
depending
The
obtained
study
provided
us
important
perspective
context.
Odontology,
Journal Year:
2019,
Volume and Issue:
107(4), P. 437 - 448
Published: Feb. 4, 2019
The
indivisible
relationship
between
the
human
host
and
its
oral
microbiome
has
been
shaped
throughout
millennia,
by
facing
various
changes
that
have
forced
adaptation
of
microorganisms
to
new
environmental
conditions.
In
this
constant
crosstalk
microbiome,
a
bidirectional
established.
provide
with
functions
it
cannot
perform
on
own
at
same
time
provides
microbes
suitable
environment
for
their
growth
development.
These
factors
can
positively
affect
promoting
diversity
balance
different
species,
resulting
in
state
symbiosis
absence
pathology.
contrast,
other
negatively
influence
composition
drive
interaction
towards
dysbiotic
state,
where
tilts
harmful
microbiome.
aim
review
is
describe
role
play
cultivating
maintaining
healthy
ecology
discuss
mechanisms
prevent
drift
dysbiosis.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
38(1), P. 110183 - 110183
Published: Jan. 1, 2022
Candida
albicans
is
a
commensal
of
the
urogenital
tract
and
predominant
cause
vulvovaginal
candidiasis
(VVC).
Factors
that
increase
circulatory
estrogen
levels
such
as
pregnancy,
use
oral
contraceptives,
hormone
replacement
therapy
predispose
women
to
VVC,
but
reasons
for
this
are
largely
unknown.
Here,
we
investigate
how
adaptation
C.
impacts
fungal
host-pathogen
interaction.
Estrogen
promotes
virulence
by
enabling
avoid
actions
innate
immune
system.
Estrogen-induced
evasion
mediated
via
inhibition
opsonophagocytosis
through
enhanced
acquisition
human
complement
regulatory
protein,
Factor
H,
on
cell
surface.
accumulation
H
dependent
surface
protein
Gpd2.
The
discovery
hormone-sensing
pathway
might
pave
way
in
explaining
gender
biases
associated
with
infections
may
provide
an
alternative
approach
improving
women's
health.
