Arthritis Research & Therapy,
Journal Year:
2022,
Volume and Issue:
24(1)
Published: July 22, 2022
Osteoarthritis
(OA)
is
an
age-related
cartilage
degenerative
disease,
and
chondrocyte
senescence
has
been
extensively
studied
in
recent
years.
Increased
numbers
of
senescent
chondrocytes
are
found
OA
cartilage.
Selective
clearance
a
post-traumatic
osteoarthritis
(PTOA)
mouse
model
ameliorated
development,
while
intraarticular
injection
cells
induced
OA.
However,
the
means
extent
to
which
affects
remain
unclear.
Here,
we
review
latent
mechanism
propose
potential
therapeutic
methods
target
OA-related
senescence,
with
emphasis
on
immunotherapies.
Natural
killer
(NK)
participate
elimination
multiple
organs.
A
relatively
comprehensive
discussion
presented
that
section.
Risk
factors
for
ageing,
obesity,
metabolic
disorders
mechanical
overload.
Determining
relationship
between
known
risk
will
help
elucidate
pathogenesis
identify
optimal
treatments.
Biochemia Medica,
Journal Year:
2019,
Volume and Issue:
29(3), P. 483 - 497
Published: July 17, 2019
The
complex
process
of
biological
aging,
as
an
intrinsic
feature
living
beings,
is
the
result
genetic
and,
to
a
greater
extent,
environmental
factors
and
time.
For
many
changes
taking
place
in
body
during
three
are
important:
inflammation,
immune
aging
senescence
(cellular
aging).
Senescence
irreversible
form
long-term
cell-cycle
arrest,
caused
by
excessive
intracellular
or
extracellular
stress
damage.
purpose
this
cell-cycles
arrest
limit
proliferation
damaged
cells,
eliminate
accumulated
harmful
disable
potential
malignant
cell
transformation.
As
age
does
not
have
be
accordance
with
chronological
age,
it
important
find
specific
hallmarks
biomarkers
that
could
objectively
determine
rate
person.
These
might
valuable
measure
physiological,
i.e.
age.
Biomarkers
should
meet
several
criteria.
example,
they
predict
monitor
basic
underlies
process,
able
tested
repeatedly
without
harming
In
addition,
indicators
processes,
pathogenic
processes
pharmacological
responses
therapeutic
intervention.
It
considered
telomere
length
weak
biomarker
(with
poor
predictive
accuracy),
there
currently
no
reliable
meets
all
necessary
Journal of Extracellular Vesicles,
Journal Year:
2019,
Volume and Issue:
8(1)
Published: June 17, 2019
ABSTRACT
This
review
analyzes
the
relationship
between
microvesicles
and
reactive
oxygen
species
(ROS).
is
bidirectional;
on
one
hand,
number
content
of
produced
by
cells
are
affected
oxidative
stress
conditions;
other
can
directly
and/or
indirectly
modify
ROS
in
extra‐
as
well
intracellular
compartments.
In
this
regard,
contain
a
pro‐oxidant
or
antioxidant
machinery
that
may
produce
scavenge
ROS:
direct
effect.
mechanism
especially
suitable
for
eliminating
extracellular
compartment.
Endothelial
microvesicles,
particular,
specific
well‐developed
machinery.
On
molecules
included
(activate
inhibit)
metabolism
their
target
cells:
indirect
be
achieved
incorporation
into
metabolic
enzymes
regulation
signaling
pathways
involved
metabolism.
Proteins,
miRNAs,
last
Journal of Cellular Physiology,
Journal Year:
2018,
Volume and Issue:
234(6), P. 8122 - 8133
Published: Nov. 11, 2018
Abstract
Mitochondria
play
an
important
role
in
maintaining
cardiac
homeostasis
by
supplying
the
major
energy
required
for
excitation–contraction
coupling
as
well
controlling
key
intracellular
survival
and
death
pathways.
Healthy
mitochondria
generate
ATP
molecules
through
aerobic
process
known
oxidative
phosphorylation
(OXPHOS).
Mitochondrial
injury
during
myocardial
infarction
(MI)
impairs
OXPHOS
results
excessive
production
of
reactive
oxygen
species
(ROS),
bioenergetic
insufficiency,
contributes
to
development
cardiovascular
diseases.
Therefore,
mitochondrial
biogenesis
along
with
proper
quality
control
machinery,
which
removes
unhealthy
is
pivotal
health.
Upon
damage
network,
components
are
recruited
segregate
target
aberrant
proteins
degradation
elimination.
Impairment
accumulation
abnormal
have
been
reported
pathogenesis
various
disorders
heart
failure.
Here,
we
provide
overview
recent
studies
describing
mechanistic
pathways
underlying
main
focus
on
cells.
In
addition,
this
review
demonstrates
potential
effects
dysregulation
disease.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2017,
Volume and Issue:
2017(1)
Published: Jan. 1, 2017
Oxidative
stress
plays
a
pivotal
role
in
developing
and
accelerating
retinal
diseases
including
age‐related
macular
degeneration
(AMD),
glaucoma,
diabetic
retinopathy
(DR),
vein
occlusion
(RVO).
An
excess
amount
of
reactive
oxygen
species
(ROS)
can
lead
to
functional
morphological
impairments
pigment
epithelium
(RPE),
endothelial
cells,
ganglion
cells
(RGCs).
Here
we
demonstrate
that
edaravone,
free
radical
scavenger,
decreased
apoptotic
cell
death,
oxidative
damage
DNA
lipids,
angiogenesis
through
inhibiting
JNK
p38
MAPK
pathways
AMD,
DR,
RVO
animal
models.
These
data
suggest
the
therapeutic
strategy
for
targeting
may
be
important
treatment
these
ocular
diseases,
edaravone
useful
treating
associated
with
stress.
Cell Proliferation,
Journal Year:
2021,
Volume and Issue:
54(7)
Published: May 24, 2021
Intervertebral
disc
degeneration
(IDD)
is
a
common
clinical
degenerative
disease
of
the
spine.
A
series
factors,
such
as
inflammation,
oxidative
stress
and
mechanical
stress,
promote
degradation
extracellular
matrix
(ECM)
intervertebral
discs
(IVD),
leading
to
dysfunction
structural
destruction
IVD.
Nuclear
factor-κB
(NF-κB)
transcription
factor
has
long
been
regarded
pathogenic
IDD.
Therefore,
NF-κB
may
be
an
ideal
therapeutic
target
for
As
multifunctional
functional
with
roles
in
variety
biological
processes,
comprehensive
understanding
function
regulatory
mechanism
IDD
pathology
will
useful
development
targeted
strategies
IDD,
which
can
prevent
progression
reduce
potential
risks.
This
review
discusses
role
signalling
pathway
nucleus
pulposus
(NP)
process
understand
pathological
NP
further
provide
targets
that
interfere
therapy.
Analytical Chemistry,
Journal Year:
2021,
Volume and Issue:
93(7), P. 3559 - 3566
Published: Feb. 11, 2021
Sensitivity,
selectivity,
visible
detection,
and
rapid
response
are
the
main
concerns
for
an
analytical
method.
Herein,
we
reported
a
metal-organic
framework
(MOF)-based
ratiometric
fluorescence
detection
strategy
hypochlorous
acid
(HClO).
The
MOF
was
prepared
with
dual
ligands,
2-aminoterephthalic
(BDC-NH2)
dipicolinic
(DPA)
Eu3+
ions
as
metal
node,
denoted
Eu-BDC-NH2/DPA.
dual-ligand
realized
emission
sensing
visual
adjusted
size
morphology
of
MOFs
to
obtain
good
dispersion
response,
provided
amino
group
special
recognition
HClO.
Thus,
exhibited
derived
from
BDC-NH2
at
433
621
nm,
respectively,
under
single
excitation
270
nm.
A
hydrogen
bond
forms
between
-NH2
HClO
weaken
blue
while
antenna
effect
kept
stable,
so
easy-to-differentiate
color
change
detection.
showed
self-calibration
reduced
background.
high
sensitivity,
low
limit
(37
nM),
short
time
(within
20
s)
were
probe.
analysis
real
samples
demonstrated
practical
application
introduction
mixed
ligands
is
effective
regulate
behaviors
improved
performance.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: May 21, 2020
Mitochondria
undergo
dynamic
fusion/fission,
biogenesis
and
mitophagy
in
response
to
stimuli
or
stresses.
Disruption
of
mitochondrial
homeostasis
could
lead
cell
senescence,
although
the
underlying
mechanism
remains
unclear.
We
show
that
deletion
phosphatase
PGAM5
leads
accelerated
retinal
pigment
epithelial
(RPE)
senescence
vitro
vivo.
Mechanistically,
is
required
for
fission
through
dephosphorylating
DRP1.
increased
fusion
decreased
turnover.
As
results,
cellular
ATP
reactive
oxygen
species
(ROS)
levels
are
elevated,
mTOR
IRF/IFN-β
signaling
pathways
enhanced,
leading
senescence.
Overexpression
Drp1
K38A
S637A
mutant
phenocopies
rescues
activation
PGAM5-/-
cells,
respectively.
Young
but
not
aging
Pgam5-/-
mice
resistant
sodium
iodate-induced
RPE
death.
Our
studies
establish
a
link
between
defective
fission,
age-dependent
oxidative
stress
response,
which
have
implications
age-related
diseases.
Heliyon,
Journal Year:
2020,
Volume and Issue:
6(5), P. e04107 - e04107
Published: May 1, 2020
Aging
is
a
degenerative,
biological,
time-dependent,
universally
conserved
process
thus
designed
as
one
of
the
highest
known
risk
factors
for
morbidity
and
mortality.
Every
individual
has
its
own
aging
mechanisms
both
environmental
conditions
(75%)
genetics
(25%)
account
aging.
Several
theories
have
been
proposed
until
now
but
not
even
single
theory
solves
this
mystery.
There
are
still
some
queries
un-answered
to
scientific
community
regarding
behind
However,
oxidative
stress
(OST)
considered
famous
that
sees
mitochondria
leading
organelles
which
largely
contribute
process.
Many
reactive
oxygen
species
(ROS)
produced
endogenously
exogenously
associated
with
But
mitochondrial
ROS
dysfunction
due
contributors
toward
Although
damage
cell
machinery,
new
evidence
suggests
their
role
in
signal
transduction
regulate
biological
physiological
processes.
Moreover,
besides
mitochondria,
other
important
such
peroxisome
endoplasmic
reticulum
also
produce
nature
provided
humans
free
radical
scavengers
called
antioxidants
protect
from
harmful
effects
ROS.
Future
predictions
aging,
biochemical
involved,
biomarkers
internal
external
can
be
easily
done
machine
learning
algorithms
computational
models.
This
review
explains
aspects
contribution
producing
importance
fighting
against
ROS,
different
models
developed
understand
complexities
