Recent Perspective of Lactobacillus in Reducing Oxidative Stress to Prevent Disease

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 769 - 769

Published: March 21, 2023

During oxidative stress, an important factor in the development of many diseases, cellular and antioxidant activities are imbalanced due to various internal external factors such as inflammation or diet. The administration probiotic Lactobacillus strains has been shown confer a range antibacterial, anti-inflammatory, antioxidant, immunomodulatory effects host. This review focuses on potential role stress inflammatory bowel diseases (IBD), cancer, liver-related context preventive therapeutic associated with Lactobacillus. article reviews studies cell lines animal models well some clinical population reports that suggest could alleviate basic symptoms related abnormal indicators IBD, cancers, liver damage, covers evidence supporting for Nrf2, NF-κB, MAPK signaling pathways alleviating inflammation, aberrant proliferation, apoptosis. also discusses unmet needs future directions research including more extensive mechanistic analyses trials Lactobacillus-based treatments.

Language: Английский

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Self‐Propelled Ultrasmall AuNPs‐Tannic Acid Hybrid Nanozyme with ROS‐Scavenging and Anti‐Inflammatory Activity for Drug‐Induced Liver Injury Alleviation

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 9, 2023

Abstract Developing nanomedicines with superior reactive oxygen species (ROS) scavenging capability has emerged as a promising strategy in treating ROS‐related diseases, for example, drug‐induced liver injury. However, designing nanoscavengers the self‐propelling ability to scavenge ROS actively remains challenging. Here, self‐propelled silica‐supported ultrasmall gold nanoparticles‐tannic acid hybrid nanozyme (SAuPTB) is designed that can effectively alleviate acetaminophen (APAP)‐induced injury by excessive and regulating inflammation. SAuPTB exhibits multienzyme activity displays significantly enhanced diffusion under hydrogen peroxide (H 2 O ). This vitro research shows eliminate ROS, increasing viability of H ‐stimulated cells reducing cytotoxicity APAP/H ‐treated AML12 cells. The vivo studies show accumulate at inflammatory sites mouse liver, resulting decrease alanine aminotransferase, aspartate reduction pro‐inflammatory cytokines chemokines, hence reduced hepatocyte necrosis, injury, mortality. Furthermore, activates nuclear erythroid 2‐related factor pathway upregulate antioxidative genes reduce oxidative stress. Finally, decreased high mobility group box 1 F4/80 + macrophages, suggesting an anti‐inflammatory response. work provides novel design nanozymes disease treatment.

Language: Английский

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Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8507 - 8507

Published: May 9, 2023

Oral cancer remains the leading cause of death worldwide. Rhein is a natural compound extracted from traditional Chinese herbal medicine rhubarb, which has demonstrated therapeutic effects in various cancers. However, specific rhein on oral are still unclear. This study aimed to investigate potential anticancer activity and underlying mechanisms cells. The antigrowth effect cells was estimated by cell proliferation, soft agar colony formation, migration, invasion assay. cycle apoptosis were detected flow cytometry. mechanism explored immunoblotting. vivo evaluated xenografts. significantly inhibited growth inducing S-phase arrest. migration through regulation epithelial-mesenchymal transition-related proteins. induced reactive oxygen species (ROS) accumulation inhibit AKT/mTOR signaling pathway. exerted vitro ROS via pathway cancer. drug for treatment.

Language: Английский

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Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 15, 2024

Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflammation, reducing oxidative stress promoting cell differentiation. The interaction between biomaterials cells significantly affects biomaterial-tissue integration regeneration. In recent years, it has been found affect various processes related to autophagy. utilization of in controlled environment become prominent approach for enhancing the capabilities. This involves regulation autophagy diverse types implicated regeneration, encompassing modulation inflammatory responses, stress, differentiation, proliferation, migration, apoptosis, extracellular matrix formation. addition, possess potential serve as carriers drug delivery, enabling either activating or inhibiting its processes. review summarizes relationship discusses role biomaterial-based advanced technologies used design autophagy-modulating are summarized, rational providing via modification chemistry surface incorporation molecules discussed. A better understanding well underlying molecular mechanisms, may lead new possibilities Video Abstract.

Language: Английский

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Attractive benzothiazole-based fluorescence probe for the highly efficient detection of hydrogen peroxide

Analytica Chimica Acta, Journal Year: 2022, Volume and Issue: 1214, P. 339939 - 339939

Published: May 14, 2022

Language: Английский

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Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 30, 2023

Background Environmental pollution and infertility are two modern global challenges that agonize personal public health. The causal relationship between these deserves scientific efforts to intervene. It is believed melatonin maintains antioxidant properties may be utilized protect the testicular tissue from oxidant effects caused by toxic materials. Methods A systematic literature search was conducted in PubMed, Scopus, Web of Science identify animal trial studies evaluated therapy’s on rodents’ against oxidative stress heavy metal non-heavy environmental pollutants. Data were pooled, standardized mean difference 95% confidence intervals estimated using random-effect model. Also, risk bias assessed Systematic Review Centre for Laboratory Experimentation (SYRCLE) tool. (PROSPERO: CRD42022369872) Results Out 10039 records, 38 eligible review, which 31 included meta-analysis. Most them showed beneficial therapy histopathology. [20 materials this including arsenic, lead, hexavalent chromium, cadmium, potassium dichromate, sodium fluoride, cigarette smoke, formaldehyde, carbon tetrachloride (CCl4), 2-Bromopropane, bisphenol A, thioacetamide, S, ochratoxin nicotine, diazinon, Bis(2-ethylhexyl) phthalate (DEHP), Chlorpyrifos (CPF), nonylphenol, acetamiprid.] pooled results increased sperm count, motility, viability body weights, germinal epithelial height, Johnsen's biopsy score, epididymis weight, seminiferous tubular diameter, serum testosterone, luteinizing hormone levels, Malondialdehyde, glutathione peroxidase, superoxide dismutase, levels. On other hand, abnormal morphology, apoptotic index, nitric oxide lower arms. presented a high most SYRCLE domains. Conclusion In conclusion, our study demonstrated amelioration histopathological characteristics, reproductive hormonal panel, markers stress. Melatonin attention as potential therapeutic agent male infertility. review registration https://www.crd.york.ac.uk/PROSPERO , identifier CRD42022369872.

Language: Английский

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Farnesoid X Receptor Plays a Key Role in Ochratoxin A-Induced Nephrotoxicity by Targeting Ferroptosis In Vivo and In Vitro

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(39), P. 14365 - 14378

Published: Sept. 26, 2023

The mycotoxin ochratoxin A (OTA) causes nephrotoxicity, hepatotoxicity, and immunotoxicity in animals humans. farnesoid X receptor (FXR) is a member of the NR family highly expressed kidney, which has an antilipid production function. Ferroptosis iron-dependent form regulated cell death involved several pathophysiological kidney injury. present study aims to evaluate role FXR ferroptosis OTA-induced nephrotoxicity mice HK-2 cells. Results showed that OTA induced as demonstrated by inducing histopathological lesions neutrophil infiltration increasing serum BUN, CRE, UA levels, Ntn-1, Kim-1, pro-inflammatory cytokine expression, decreasing IL-10 expression viability treatment also deficiency, ROS release, MDA level increase, GSH content decrease, 4-HNE labile iron pool lipid peroxidation levels well Acsl4, TFR1, HO-1 mRNA protein GPX4 FTH expressions, mitochondrial activator (GW4064) rescued accumulation peroxides, intracellular ROS, Fe2+, inhibited ferroptosis, alleviated nephrotoxicity. inhibitor (Fer-1) prevented attenuated Collectively, this elucidates played critical via regulation provides novel strategy against

Language: Английский

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Effects of carotenoids on mitochondrial dysfunction

Biochemical Society Transactions, Journal Year: 2024, Volume and Issue: 52(1), P. 65 - 74

Published: Feb. 22, 2024

Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the state is a result of increased production reactive oxygen species (ROS) or inadequate protection. ROS are produced through several mechanisms in cells including during mitochondrial oxidative phosphorylation. Increased mitochondrial-derived associated with dysfunction, early event age-related diseases such as Alzheimer's (ADs) metabolic disorders diabetes. AD post-mortem investigations affected brain regions have shown accumulation damage to macromolecules, stress has been considered important contributor disease pathology. An increase which leads levels superoxide, hydrogen peroxide other potentially vicious cycle both causative consequence dysfunction. Mitochondrial dysfunction may be ameliorated by molecules capacities that accumulate mitochondria carotenoids. However, role carotenoids mitigating not fully understood. A better understanding antioxidants function promising lead towards development novel effective treatment strategies for diseases. This review evaluates summarises some latest developments insights into effects on focus properties The mitochondria-protective key therapeutic targeting emerging drug

Language: Английский

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Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate

Cancers, Journal Year: 2021, Volume and Issue: 13(22), P. 5791 - 5791

Published: Nov. 18, 2021

Melanoma originates from the malignant transformation of melanocytes and is one most aggressive forms cancer. The recent approval several drugs has increased chance survival although a significant subset patients with metastatic melanoma do not show long-lasting response to these treatments. complex cross-talk between oxidative stress catabolic process autophagy seems play central role in all aspects pathophysiology, initiation progression metastasis, including drug resistance. However, determining fine cancer death redox disruption still fundamental challenge order advance both basic translational this field. In summarize interactions among reactive oxygen nitrogen species, machinery proliferation/growth/death/apoptosis/survival, we provide here narrative review preclinical evidence for drugs/treatments that modulate cells. significance potential pharmacological targeting (also through multiple combination approaches) two different events, which can contribute independently or simultaneously fate melanoma, may help define new processes their interconnections underlying skin biology unravel reliable approaches.

Language: Английский

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Novel Bile Salt Stabilized Vesicles-Mediated Effective Topical Delivery of Diclofenac Sodium: A New Therapeutic Approach for Pain and Inflammation

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(9), P. 1106 - 1106

Published: Sept. 5, 2022

The oral delivery of diclofenac sodium (DNa), a non-steroidal analgesic, anti-inflammatory drug, is associated with various gastrointestinal side effects. aim the research was to appraise potential transdermal DNa using bilosomes as vesicular carrier (BSVC) in inflamed paw edema. DNa-BSVCs were elaborated thin-film hydration technique and optimized 31.22 multilevel categoric design Design Expert® software 10 (Stat-Ease, Inc., Minneapolis, MI, USA). effect formulation variables on physicochemical properties BSVC, well optimal selection, investigated. BSVCs evaluated for parameters including entrapment efficiency (EE%), vesicle size (VS), zeta (ZP) permeation studies. BSVC characterized vitro release, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) incorporated into hydrogel base. DNa-BSVC gel effectiveness assessed vivo carrageenan-induced edema animal model via cyclooxygenase 2 (COX-2), interleukin 6 (IL-6), Hemooxygenase 1 (HO-1) nuclear factor-erythroid factor2-related factor (Nfr-2) that potentiate anti-oxidant activity coupled histopathological investigation. resulting vesicles presented VS from 120.4 ± 0.65 780.4 0.99 nm, EE% 61.7 3.44 93.2 2.21%, ZP -23.8 2.65 -82.1 12.63 mV 582.9 32.14 1350.2 45.41 µg/cm2. nano-scaled spherical non-overlapped bands their constituents FTIR. Optimized has superior skin permeability ex approximately 2.5 times greater than solution. Furthermore, histological investigation discovered formed had no irritating properties. It found suppressed changes oxidative inflammatory mediators IL-6 consequently enhanced Nrf2 HO-1 levels. Moreover, reduction percent by about three-folds confirmed alterations. results revealed could be promising drug system boost efficacy enhancing suppressing inflammation rat

Language: Английский

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