The nonspecific effects of COVID-19 vaccination upon non-COVID-19 all-cause mortality (NCACM) in the population of England: Effects of age, sex, COVID-19 variant, vaccination history, and time in a real-world study from Jan-21 to May-23

Published: Jan. 4, 2024

All vaccines exhibit specific and nonspecific effects. Specific effects are shown by the efficacy against target pathogen, while can be detected change in all-cause mortality. The real-world non-COVID-19 mortality (NCACM) data for population of England between January 2021 May 2023 was assessed. administered were based on original Wuhan antigen. Each gender age group, along with COVID-19 variant shows its own unique NCACM vaccination benefit/disbenefit time profile. disease/death per se is undisputed, however, outcomes COVID–19 far more nuanced than have been widely appreciated. This confirms an earlier study unanticipated influenza winter Interestingly, a high proportion beneficial occurred during first 21 days following vaccination, worst example increased fourth dose 19–40-year-olds interval >21 post which led to 3- 10-times higher unvaccinated. By Omicron variant, those aged 90+ mostly adverse. increase reach their maximum effect second week groups below 50 years, rising third 70+. Finally, we discuss mechanisms could induce wider Most these seem depend gene regulation noncoding RNAs also interact mRNAs. We suggest that further international studies required discern different variants other three prevalent UK, types/manufacturer employed around world. only speculate regarding persons asymptomatic infection, vaccine waning. Vaccines not need effective as primarily determined antibody production, but minimize any adverse

Language: Английский

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Alternations in miR-155 and miR-200 serum levels can serve as biomarkers for COVID-19 in the post-mass vaccination era

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: May 25, 2024

Language: Английский

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Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 7, 2024

The pandemic of coronavirus disease-19 (COVID-19), provoked by the appearance a novel named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), required worldwide healthcare emergency. This has elicited an immediate need for accelerated research into its mechanisms disease, criteria diagnosis, methods forecasting outcomes, and treatment approaches. microRNAs (miRNAs), are diminutive RNA molecules, that non-coding participate in gene expression regulation post-transcriptionally, having important participation regulating immune processes. miRNAs have granted substantial interest their impact on viral replication, cell proliferation, modulation how host’s system responds. narrative review delves host miRNAs’ multifaceted roles within COVID-19 context, highlighting involvement disease progression, diagnostics, prognostics aspects, given stability biological fluids varied profiles when responding to infection. Additionally, we discuss complicated interactions between SARS-CoV-2 cellular machinery facilitated revealing dysregulation miRNA advances evasion, inflammatory responses. Furthermore, it investigates potential as therapeutic agents, whether synthetic or naturally occurring, which could be harnessed either mitigate harmful inflammation enhance antiviral However, searching more deeply is needed clarify involved pathogenesis COVID-19, diagnosis processes, prognostic assessments, approaches patients.

Language: Английский

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Her Parasites: A poetic ecospiritual perspective of the COVID-19 pandemic and nature's intelligence

Journal of Ecohumanism, Journal Year: 2024, Volume and Issue: 3(2), P. 189 - 213

Published: March 1, 2024

In this transdisciplinary perspective, I present my initial ecospiritual thinking about the COVID-19 pandemic in a poem, titled Her Parasites. identify with other thinkers – both those science and not who articulated ecophilosophical musings various ways, some of whom were met mockery censure. hope that it will inspire openness sense curiosity, draw on metaphysical insights from Vedic treatises literature environmental decline, zoonotic epidemiology, health science, animal agriculture, ethics, sentience to explain poem’s philosophical ecological framework. focus scientific knowledge epidemics caused by viruses transcend species boundaries, why cross-species hopping occurs, nature (and incredible intelligence) such viruses. invite readers consider ancient principles articulate rationale for living harmoniously sentient beings entities. Considering unseen association between cruelty explained through laws Karmā, possibility one lessons Mother Earth might have wanted Homo sapiens learn is its need alter diet. end discussion value change. The downplaying or denial (strategies overcome psychological discomfort incongruence loving animals eating them, as described social psychology), barrier However, observed lens, cognitive dissonance suggests innately humane, realisation which hold key dietary

Language: Английский

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Herbal-based tea bag reduces SARS-CoV-2 variant symptoms and infection duration via microRNA regulation: Clinical and mechanistic insights

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106530 - 106530

Published: Oct. 31, 2024

Language: Английский

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Exploring plasma expression levels of miR-200c-3p, miR-150, and miR-155 in SARS-CoV-2 positive and negative subjects

Future Virology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 6

Published: Nov. 16, 2024

Aim The global pandemic caused by SARS-CoV-2 has driven significant research into diagnostic methods, particularly the use of circulating microRNAs (miRNAs) as potential prognostic biomarkers. This study investigated plasma expression levels miR-200c-3p, miR-150, and miR-155 in both positive negative subjects.

Language: Английский

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Changes in miRNA Pattern Expression Associated With COVID-19 Severity

In Vivo, Journal Year: 2024, Volume and Issue: 39(1), P. 482 - 490

Published: Dec. 31, 2024

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection, manifests a wide range of clinical symptoms ranging from mild to moderate and severe. Host-related factors influence the course infection; for instance, expression host microRNAs (miRNAs) could progression complications COVID-19. This study aimed determine pattern endogenous miRNAs in 80 severe COVID-19 patients compared group healthy individuals.

Language: Английский

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Circulating microRNA profile in response to remdesivir treatment in coronavirus disease 2019 (COVID-19) patients

Archives of Virology, Journal Year: 2023, Volume and Issue: 168(7)

Published: June 28, 2023

Language: Английский

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Host Genetics and COVID-19: Genes Underlying the Patterns of Susceptibility and Prognosis

Gene Expression, Journal Year: 2023, Volume and Issue: 22(3), P. 222 - 231

Published: Sept. 21, 2023

Host-specific genetics, such as epigenetic profiles and genetic variants, can contribute to the pathogenesis of infectious diseases. Strong associations have been previously identified in infections by human immunodeficiency virus (HIV), Plasmodium falciparum, norovirus, influenza A virus. Despite efforts characterize role host genetics severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, this comprehension remains incipient. Coronavirus disease 2019 (COVID-19) evolve with a wide spectrum manifestations, ranging from asymptomatic mild cases forms distress syndrome, multi-organ complications, even death. Classic clinical risk factors only partially explain interindividual variability, suggesting that may heterogeneity courses. Robust evidence has revealed multiple genes (ABO, PPP1R15A, SLC6A20, IFNAR2, OAS, TYK2, CCR2, CCR5, TLR7, ApoE, TMPRSS2, HLA, ACE2, etc.) susceptibility and/or severity SARS-CoV-2 infection. In addition, behind established considered: at least four loci associated COVID-19 (DPP9, FOXP4, SFTPD MUC5B) linked lung fibrosis, interstitial disease, carcinomas, decreased function. summary, identifying host-specific improve our knowledge groups for infection outcomes, well biological mechanisms therapeutic relevance. Therefore, present literature review aims understand underlying patterns prognosis COVID-19.

Language: Английский

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Evaluation of the Relationship Between Serum miR-200b-3p and miR-214-3p Expression Levels with Soluble ACE2 and TMPRSS2 in COVID-19 Patients

Deleted Journal, Journal Year: 2023, Volume and Issue: In Press(In Press)

Published: Oct. 11, 2023

Background: The emergence and rapid global spread of the coronavirus disease 2019 (COVID-19) has presented a significant health challenge. Severe acute respiratory syndrome 2 (SARS-CoV-2) infects human host cells through interaction angiotensin-converting enzyme (ACE2) transmembrane serine protease (TMPRSS2), which serve as main regulators for viral entry. Specifically, ACE2 TMPRSS2 genes are influenced by two microRNAs: miR-200b-3p miR-214-3p, respectively. objective this study was to explore association between serum levels miR-214-3p presence circulating in severe non-severe cases COVID-19. Objectives: This sought examine potential utility microRNAs biomarkers assessing severity progression. Additionally, aimed elucidate interplay proteins, play crucial roles facilitating SARS-CoV-2 entry infection. Methods: practical-foundational involved collection samples from 61 hospitalized patients with confirmed COVID-19 31 healthy individuals. Subsequently, enzyme-linked immunosorbent assay (ELISA) technique utilized measure concentrations blood samples. expression were analyzed using real-time polymerase chain reaction (PCR). statistical analysis data conducted GraphPad Prism software (version 8.02) SPSS 19.0), ensuring accurate interpretation results. Results: findings revealed increases peripheral COVID-19, compared individuals (P < 0.001 P 0.01, respectively). Similarly, exhibited higher than subjects 0.0001). decreased both patients, 0.01 0.0001, Moreover, decrease observed those 0.001). Furthermore, identified negative correlation levels. Conclusions: above-mentioned suggest that might be prognosis patients.

Language: Английский

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