Adipose cell induction under the impacted tooth and extraction facilities (Clinical therapy)

International Journal of Applied Dental Sciences, Journal Year: 2024, Volume and Issue: 10(2), P. 253 - 261

Published: Jan. 1, 2024

Background: Third molar extraction is one of the most common oral and maxillofacial surgeries. Impaction happens when teeth don't erupt in time. This produces dental arch space too much soft tissue, a hereditary disease that affects eruption, length arch, amount available for emerging teeth, placement size neighboring may all cause tooth impaction. The aim this study to facilitating difficulties bleedings. Martial Methods: Case control impacted used an adipose cell injection sites case group. groups injected with cells while didn't inject any cells. Tomography, difficulty bleeding tests evaluation before after intervention. Results: Bleeding degrees group were highest than significant differences (p. value 0.05). Difficulty both evaluated resulted high levels at it was low group.Conclusion: novel concluded under around led make more facilitated decreasing bleeding. formation tissue 2 weeks transplantation reduces pressure on moth gingiva.

Language: Английский

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Dose-Dependent Toxicological and Histological Effects of Chloramphenicol in Nude Mice

International Journal of Design & Nature and Ecodynamics, Journal Year: 2024, Volume and Issue: 19(3), P. 1061 - 1067

Published: June 25, 2024

Chloramphenicol is a widely used broad-spectrum antibiotic in both human and veterinary medicine.Although it successful treating number of bacterial diseases, concerns have been raised about its negative effects.To examine the toxicological histological consequences chloramphenicol vivo, this study naked mouse model.After injection, health cells was assessed using examinations liver, kidney, heart tissues.The cell viability tissues decreased by 39.02%, 43.04%, 36.25%,respectively, at highest dose (100mg/kg body weight).The kidneys, heart, respectively, each had an average damage score 3.5, 4.0, 3.6 maximum dosage, according to findings, which indicated serious organ damage.Because kidney's role excreting drugs, toxic effects seen were notably more pronounced organ.These findings highlight potential risks chloramphenicol, particularly high dosages, need for research understand mechanisms underlying chloramphenicol-induced toxicity.

Language: Английский

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Apremilast Treatment of Cancer in Mice Tumorised with Breast Cancer: In Vivo Study

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 30(7)

Published: Jan. 1, 2023

It is widely accepted that vascular endothelial growth factor, often abbreviated as VEGF, an important mediator in the process of tumor angiogenesis, which includes neovascularization human breast cancer.Patients with either node-positive or node-negative cancer have a worse prognosis overall if there are high levels VEGF tissue.It would seem logical to expect poor given these circumstances.There evidence partial estrogen receptor agonist apremilast may increase quantity mRNA generated cells, suggesting hormones regulate amount expressed.However, findings clinical studies show increases average survival rates while reducing incidence metastases.These results raise questions about apremilast's efficacy adjuvant treatment for estrogen-dependent cancer.In this study, we demonstrate first time can lower extracellular vivo using solid MCF-7 tumors naked mice.Nothing like has ever been done.Following injection apremilast, seen cell culture conditions were dramatically decreased.The outcomes found supported by findings.

Language: Английский

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Correlation between the Extraction of Permanent Teeth in Children and Future Growth of Third Molar

E3S Web of Conferences, Journal Year: 2023, Volume and Issue: 391, P. 01131 - 01131

Published: Jan. 1, 2023

Background: permanent molar (M3) formation, morphology, and agenesis vary greatly between individuals. This study examines how removing the lower first affects position angle of developing third in 7- to 10-year-olds. Method: Radiographs Two groups from southern Iraq were identified: those who had one or more molars extracted ages 7 10 did not. Both panoramic radiographs taken at 8.5 years before extraction. 80 extracted, 50 retained molars. Comparing used independent sample tests. Results: The moved significantly mesially group extraction (P <0.05), righted itself than it non-extraction <0.05). these results different what was seen non-extraction. These two findings presented a striking contrast obtained control that not undergo When came movement downward, there's statistical significant difference terms vertical 3rd molar. Conclusion: An encouraged mesial up righting while dentition still process developing. Because this, probability erupting future may increase.

Language: Английский

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Evaluating the Efficacy of Nikant Doxycycline Sutures in Reducing Surgical Site Infections Following Appendectomies

INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS, Journal Year: 2023, Volume and Issue: 06(07)

Published: July 12, 2023

Background: In appendectomies, surgical site infections (SSIs) provide a serious post-operative issue. The purpose of this study was to compare the antimicrobial alternative Nikant doxycycline sutures regular polyamide in terms how well they reduced risk SSIs. Materials and Methods: 79 appendectomy patients were split into two groups for study: main group 30 who used control 49 received conventional sutures. A comprehensive questionnaire employed collect data, SPSS version 17 analysis. p-value 0.05 or lower deemed statistically significant. Results: Patients' rates 7.6%. Traditional utilised by with 1.3 percent infection rate, but had 6.3 rate. This distinction lacked statistical significance. Infected individuals hospital longer than those not infected, more likely have peritonitis necrotic appendicitis. Conclusion: According our research, SSI significantly However, their use did result any further issues, suggesting that might be secure replacement suturing appendectomies.

Language: Английский

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Establishment of amygdalin antitumor efficacy against human acute monocytic leukemia cell line (THP‐1) with antimicrobial investigations, in vitro Study

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 13, 2023

Abstract Leukemia is an incurable disease; it exhibits strong resistance to chemotherapy and other therapies, its seriousness not only in this fact but also, represents the most common childhood cancer, mortality. In study, cytotoxic of amygdalin (AMG) against cell line human monocytic leukemia (THP-1) was recoded attempting for providing a cure such monster cancerous type, be siding determining pharmacological effects as anti-microbial activity. The cells were exposed Vit b17 24 hr at 37°C different concentrations, effect determined via MTT assay. supernatant collected analyzing oxidant/antioxidant status, apoptotic markers, results showed marked anti-proliferative which concentration time-dependent, lipid peroxidation content significantly decreased while total thiol increased treated line, significant up-regulation transcript level Caspase-3 (Cas-3) Bcl-2-associated X protein (Bax) down-regulation B-cell lymphoma 2 (BCL-2). Furthermore, bacterial activity detected Minimum Inhibitory Concentration (MIC), Bactericidal (MBC), Disc Diffusion assays, antifungal evaluation done by Fungicidal (MFC). Antimicrobial experiments revealed that AMG exerted potent, broad-spectrum antimicrobial towards diversity dangerously infected pathogens. conclusion, prevailing research suggests effective antibacterial substance wide range microbial pathogens cause disease, addition anticancer leukemia.

Language: Английский

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Retracted: In Vivo Growth Inhibition of Human Caucasian Prostate Adenocarcinoma in Nude Mice Induced by Amygdalin with Metabolic Enzyme Combinations

BioMed Research International, Journal Year: 2023, Volume and Issue: 2023(1)

Published: Jan. 1, 2023

[This retracts the article DOI: 10.1155/2022/4767621.].

Language: Английский

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Correlation of Angiotensin-converting Enzyme 2 Gene (rs1514283) Polymorphism with the Incidence of COVID-19

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2022, Volume and Issue: 29(1)

Published: Jan. 1, 2022

It has been a busy year for coronaviruses, with the most recent one causing severe coronavirus illness in 2019 (COVID-19). is broadly distributed many human tissues and organs as potential SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2). ACE2 provides homeostatic modulation of circulation angiotensin II levels by acting physiological counterbalance to ACE. They have linked COVID-19 disease acquisition, progression, severity. As result, we investigated how variations epigenetic variables affect infection susceptibility outcomes terms age, gender, ethnicity. Debates raged over etiology this occurrence. important note that further research required demonstrate efficacy recombinant ACE2-derived peptides fighting SARSCoV-2 variants. Better recognition host genetic, well function properties variations, would assist explaining clinical disparities between individuals contribute development remedies managing future epidemics, an essential hypertension (EH). We wanted see gene polymorphisms activity correlated incidence Iraqi province Al-Diwaniya. A total 63 patients 70 (NT) controls were genotyped using Sequenom Mass-ARRAY RS1000 ACE2. Participants' rs1514283 SNP was COVID-19.

Language: Английский

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Bleeding Control of Dental Extraction in Patients Treated with Heparin Therapy

Journal of Pharmaceutical Negative Results, Journal Year: 2022, Volume and Issue: unknown, P. 3457 - 3463

Published: Oct. 21, 2022

Background: The administration of antiplatelet drugs to patients as part heparin therapy is one method that can be used prevent thrombosis. This done either prophylactically or in who are undergoing percutaneous coronary intervention. purpose this study was investigate whether not removing teeth prior treatment with dual medication effective. Materials and methods: There were a total 200 people investigated for having dental extractions on them. epinephrine fraction the adenosine collagen operative surface, well post-surgical measures adverse consequences, both evaluated. Following completion surgical procedure, all given tranexamic acid-impregnated gauzes alveolar sutures their post-operative care. For making comparisons between quantitative variables, student's t-test Pearson correlation coefficient utilized. As consequence these comparisons, descriptive statistics computed examined. We considered value P less than 0.05 statistically significant. Results: Both fraction, which measured at 441 ±22.3 seconds range 13050 350 seconds, 201± 12.23 130-350 longer typical range. results show fractions Because we took necessary precautions after surgery, single patient experienced any complications like bleeding, hematoma, infection. Conclusion: It possible safely perform receiving antiaggregant by use non-resorbable gauze had been impregnated acid. instructed hold place twenty minutes.

Language: Английский

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Role of SNPs of IL6 gene in the incidence and progression of COVID19 patients in Wasit province

Journal of Pharmaceutical Negative Results, Journal Year: 2022, Volume and Issue: 13(S01)

Published: Jan. 1, 2022

Background: SARS-coronavirus 2 is the causative of COVID-19 pandemic.(SARS-COV-2).There a correlation between illness severity and cytokines proinflammation such as interleukin-6 (IL-6).The amount cytokine produced might be affected by polymorphisms in regulatory areas genes cytokine.In this study, an Iraqi population was used to investigate possible connection three IL-6 promoter SNPs susceptibility.Methods: The goal cohort study required participation total 97 individuals, 52 whom had been diagnosed with severe 45 intermediate COVID-19.In order determine genotypes selected region gene, genomic DNA extracted from peripheral blood leukocytes patients utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.This done establish baseline for future research.These single nucleotide were denoted SNP names rs13306435 (T > A), rs2069860 (A T), rs2069830 T).Results: There no significant changes seen genotype or allele distribution chosen gene levels moderate COVID-19.These included (-395 T (-632A (-612A T). Conclusion:According results our investigation, these do not seem linked Arabian community Iraq.

Language: Английский

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