Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(9), P. 1515 - 1515

Published: Sept. 15, 2022

Alzheimer's disease (AD) is a neurodegenerative characterized by tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence Aβ-amyloid peptide, protein, oxidative stress, an exacerbated neuro-inflammatory response. This review aims to offer updated compendium most recent promising advances AD treatment through administration phytochemicals. literature survey was carried out electronic search following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, Web Science regarding published works that included molecular mechanisms signaling pathways targeted phytochemicals various experimental models vitro vivo. results studies showed use against has gained relevance due their antioxidant, anti-neuroinflammatory, anti-amyloid, anti-hyperphosphorylation properties protein. Some bioactive compounds from plants have been shown ability prevent stop progression Alzheimer's.

Language: Английский

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Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Dec. 31, 2022

Abstract Since ancient times, plants have been an extensive reservoir of bioactive compounds with therapeutic interest for new drug development and clinical application. Cucurbitacins are a compelling example these leads, primarily present in the plant kingdom, especially Cucurbitaceae family. However, natural also known several genera within other families. Beyond family, they families, as well some fungi one shell-less marine mollusc. Despite abundance cucurbitacins different species, their obtaining isolation is limited, result, increase chemical synthesis has developed by researchers. Data on anticancer activities were collected from databases such PubMed/MedLine, TRIP database, Web Science, Google Scholar, ScienceDirect information was arranged sequentially better understanding antitumor potential. The results studies showed that significant biological activities, anti-inflammatory, antioxidant, antimalarial, antimicrobial, hepatoprotective In conclusion, there studies, both vitro vivo reporting this important anticancer/chemopreventive potential; hence comprehensive review topic recommended future research.

Language: Английский

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Effects of medical plants on alleviating the effects of heat stress on chickens

Poultry Science, Journal Year: 2024, Volume and Issue: 103(3), P. 103391 - 103391

Published: Jan. 11, 2024

Over the past decades, global climate change has led to a significant increase in average ambient temperature causing heat stress (HS) waves. This resulted more frequent waves during summer periods. HS can have detrimental effects on poultry, including growth retardation, imbalance immune/antioxidant pathways, inflammation, intestinal dysfunction, and economic losses poultry industry. Therefore, it is crucial find an effective, safe, applicable, economically efficient method for reducing these negative influences. Medicinal plants (MPs) contain various bioactive compounds with antioxidant, antimicrobial, anti-inflammatory, immunomodulatory effects. Due biological activities of MPs, could be used as promising thermotolerance agents diets conditions. Nutritional supplementation MPs been shown improve performance, antioxidant status, immunity, health heat-exposed chickens. As result, several types herbs supplemented mitigate harmful review aims discuss consequences explore use different traditional enhance status

Language: Английский

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Multipurpose packaging system based on intelligent carboxymethyl cellulose film and activated cellulose acetate electrospun nanofibers for seafoods

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140115 - 140115

Published: Jan. 19, 2025

Language: Английский

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Isolation and spectroscopic characterization of anticancer phytochemicals from Artemisia laciniata : a combined experimental and theoretical investigation using ADMET analysis and in silico molecular docking simulation against key cancer targets

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 28, 2025

Artemisia laciniata, a high-altitude medicinal herb, possesses diverse therapeutic properties. This study conducted comprehensive phytochemical analysis of the whole plant, leading to isolation 15 secondary metabolites (1–15) across various classes: flavonoids (1-6), triterpenoids (7, 8), sesquiterpenoid lactones (9, 10) and furanocoumarins (11, 12) along with three steroids (13-15). These compounds were characterized using NMR (1HNMR,13C NMR, 2D NMR), IR, HRMS UV-VIS. All reported for first time from this compound 10 being novel natural product. In-vitro antitumor activity was evaluated against lung (A549), colon (HCT116), prostate (PC3) breast (T47D) cancer cell lines. Compounds 3, 4, 6, 7, 8 demonstrated significant activity, 7 exhibiting IC50 values 28 µM. In silico molecular docking ADMET assess pharmacokinetics pharmacodynamics, revealing strong binding affinities particularly PD-L1, highlighting their potential target multiple cancer-related pathways. concludes that A. laciniata contains potent anticancer phytochemicals key proteins involved in development, as by MTT assay results.

Language: Английский

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Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation and Gastrointestinal Disorders

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 454 - 454

Published: Feb. 12, 2025

Conditions like diabetes mellitus (DM), cancer, infections, inflammation, cardiovascular diseases (CVDs), and gastrointestinal (GI) disorders continue to have a major global impact on mortality morbidity. Medicinal plants been used since ancient times in ethnomedicine (e.g., Ayurveda, Unani, Traditional Chinese Medicine, European Medicine) for the treatment of wide range disorders. Plants are rich source diverse phytoconstituents with antidiabetic, anticancer, antimicrobial, antihypertensive, antioxidant, antihyperlipidemic, cardioprotective, immunomodulatory, and/or anti-inflammatory activities. This review focuses 35 most commonly reported these disorders, particular emphasis their traditional uses, phytoconstituent contents, pharmacological properties, modes action. Active phytomolecules therapeutic potential include cucurbitane triterpenoids, diosgenin, limonoids (azadiradione gedunin), which exhibit antidiabetic triterpenoids specifically activating Glucose Transporter Type 4 (GLUT4) translocation. Capsaicin curcumin demonstrate anticancer activity by deactivating NF-κB arresting cell cycle G2 phase. Antimicrobial activities observed piperine, reserpine, berberine, dictamnine, chelerythrine, allitridin, latter two triggering bacterial lysis. Quercetin, catechin, genistein suppressing CD8+ cytotoxic T function. Ginsenoside Rg1 ginsenoside Rg3 treating diseases, PPARα promoter, PI3K/Akt pathway. In contrast, ternatin, tannins, quercitrin regulating arachidonic acid metabolism cyclooxygenase (COX) lipoxygenase activity. Further studies warranted fully investigate clinical benefits phytoconstituents, as well elucidate underlying molecular mechanisms

Language: Английский

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Novel ether derivatives of 11-azaartemisinins with high order antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 103, P. 129700 - 129700

Published: March 12, 2024

Language: Английский

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Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 1016 - 1016

Published: Aug. 20, 2024

This study aimed to investigate the antioxidant and anti-inflammatory activities mechanism of Artemisia dracunculus (A. dracunculus) abrotanum abrotanum) ethanol extracts in acute rat inflammation induced Wistar male rats with turpentine oil. The characterization polyphenolic compounds was conducted using UV–Vis Fourier-transform infrared spectroscopy high-performance liquid chromatography coupled mass spectrometry techniques. activity evaluated vitro by DPPH, FRAP, H2O2, NO scavenging tests vivo measuring total oxidative status (TOS), capacity (TAC), stress index (OSI), 8-hydroxy-deoxyguanosine (8-Oxo-dG), advanced oxidation protein products (AOPP), malondialdehyde (MDA), nitric oxide (NO), 3-nitrotyrosine (3NT), thiols (SH). Inflammation nuclear factor-kB-p65 (NfkB-p65) NLRP3 inflammasome activation IL-1β, IL-18, gasdermin D. Liver renal toxicity determined following transaminases (ALT AST), creatinine, urea. experimental results indicated that A. have moderate had an effect NfkB-p65, IL-1b, D serum level reduction. correlated chemical composition extracts. These bring evidence-based use abrotanum’s traditional contemporary medicine.

Language: Английский

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Artemisieverolides A—G, Sesquiterpenoid Trimers from Artemisia sieversiana and Their Antihepatic Fibrosis Activity

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Comprehensive Summary Artemisieverolides A—G ( 1 — 7 ), seven unreported sesquiterpenoid trimers, were isolated from Artemisia sieversiana (Asteraceae), and elucidated by comprehensive spectral data electronic circular dichroism (ECD) calculations. Compounds , 2 4 6 unambiguously determined the single‐crystal X‐ray diffraction. Artemisieverolide A ) was an unprecedented guaianolide trimer featuring a rare 5/7/4/7/5 carbon skeleton biogenetically derived [2+2] cycloaddition 2‐methylbicyclo[2.2.1]‐2‐heptene ring through Diels‐Alder (D‐A) reaction. B—G trimers generated two D‐A reactions. 3 5 exhibited inhibitory activities on proliferation of HSC‐LX‐2 with IC 50 values 52.6, 58.4, 54.8 μmol/L, about folds more active than silybin (IC = 149.4 μmol/L). Furthermore, compounds suppressed expression collagen I in TGF‐β1‐stimulated HSC‐LX‐2.

Language: Английский

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Spectroscopic investigation and insecticidal effects of two natural alkynes from Artemisia campestris, 2,4-pentadiynylbenzene and capillene, against Spodoptera littoralis larvae and non-target organisms

Crop Protection, Journal Year: 2025, Volume and Issue: unknown, P. 107163 - 107163

Published: Feb. 1, 2025

Language: Английский

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