Advances in Traditional Medicine, Journal Year: 2023, Volume and Issue: 24(2), P. 449 - 458
Published: Sept. 14, 2023
Language: Английский
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 692 - 692
Published: May 27, 2024
There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.
Language: Английский
Citations
21
Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3638 - 3638
Published: Sept. 2, 2022
Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and strawberries. The beneficial effects phloretin are mainly associated with its potent antioxidant properties. modulates several signaling pathways molecular mechanisms to exhibit therapeutic benefits against various diseases including cancers, diabetes, liver injury, kidney encephalomyelitis, ulcerative colitis, asthma, arthritis, cognitive impairment. It ameliorates complications diabetes such as cardiomyopathy, hypertension, depression, memory impairment, delayed wound healing, peripheral neuropathy. effective microbial infections Salmonella typhimurium, Listeria monocytogenes, Mycobacterium tuberculosis, Escherichia coli, Candida albicans methicillin-resistant Staphylococcus aureus. Considering benefits, it generated interest for pharmaceutical development. However, poor oral bioavailability major drawback. Therefore, efforts have been undertaken enhance by modifying physicochemical properties structure, developing nanoformulations. In review, we discussed pharmacological actions, underlying targets phloretin. Moreover, review provides insights into pharmacokinetic characteristics, approaches promote development applications future. Although convincing experimental data reported, human studies not available. order ascertain safety, further preclinical needed encourage clinical
Language: Английский
Citations
43
Published: Jan. 11, 2024
Polyphenols, long-used components of medicinal plants, have drawn great interest in recent years as potential therapeutic agents because their safety, efficacy, and wide range biological effects. Approximately 74% the world's population still uses plant-based medicines, indicating ongoing significance phytochemicals for human health. The study emphasizes growing body research examining role polyphenols uncovering anti-adipogenic anti-obesity properties. Functions including phenylpropanoids, flavonoids, terpenoids, alkaloids, glycosides, phenolic acids are distinct due to changes chemical diversity, structural characteristics. This review methodically investigates mechanism how naturally occurring mediate obesity metabolic function. To this end, hormonal control hunger has inhibit pro-obesity enzymes such pancreatic lipase, promotion energy expenditure, modulation adipocytokine production. Specifically, affect insulin, a hormone that is essential regulating blood sugar, they also play part complex web factors progression obesity. explores immunomodulatory properties polyphenols, providing insight into ability improve immune effects on gut health, improving number commensal bacteria, cytokine production suppression, cell mediation, natural killer cells macrophages. Taken together, continuous studies required prudent precise mechanisms underlying polyphenols' immunomodulation. In interim, holistic approach health promotes consumption foods drinks high polyphenols. lays groundwork future developments, derivatives may provide answer urgent worldwide issues. compilation knowledge paves way discoveries global treatment pressing concerns diseases.
Language: Английский
Citations
15
Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 221 - 221
Published: Feb. 14, 2024
Polyphenols, long-used components of medicinal plants, have drawn great interest in recent years as potential therapeutic agents because their safety, efficacy, and wide range biological effects. Approximately 75% the world’s population still use plant-based compounds, indicating ongoing significance phytochemicals for human health. This study emphasizes growing body research investigating anti-adipogenic anti-obesity functions polyphenols. The polyphenols, including phenylpropanoids, flavonoids, terpenoids, alkaloids, glycosides, phenolic acids, are distinct due to changes chemical diversity structural characteristics. review methodically investigates mechanisms by which naturally occurring polyphenols mediate obesity metabolic function immunomodulation. To this end, hormonal control hunger has inhibit pro-obesity enzymes such pancreatic lipase, promotion energy expenditure, modulation adipocytokine production. Specifically, affect insulin, a hormone that is essential regulating blood sugar, they also play role, part, complex web factors progression obesity. explores immunomodulatory properties providing insight into ability improve immune effects on gut health, improving number commensal bacteria, cytokine production suppression, cell mediation, natural killer cells macrophages. Taken together, continuous studies required understand prudent precise underlying polyphenols’ In interim, holistic approach health promotes consumption foods drinks high lays groundwork future developments, derivatives may provide answer urgent worldwide issues. compilation knowledge paves way discoveries global treatment pressing concerns diseases.
Language: Английский
Citations
15
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Delving into the intricate role of phytonutrients is paramount to effectively preventing and treating chronic diseases. Phytonutrients are "plant-based nutrients" that positively affect human health. perform primary therapeutic functions in management treatment various It reported different types pathogenesis occur due excessive production oxidants (reactive nitrogen species reactive oxygen species). The literature shows a higher intake fruits, vegetables, other plant-based food inversely related Due many (antioxidants) medicinal plants, they considered major agents for main purpose this review summarize involved Fourteen discussed review, such as polyphenols, anthocyanin, resveratrol, phytosterol (stigmasterol), flavonoids, isoflavonoids, limonoids, terpenoids, carotenoids, lycopene, quercetin, phytoestrogens, glucosinolates, probiotics, which well-known their beneficial effects on body pathological conditions. concluded play prevention diabetes mellitus, obesity, hypertension, cardiovascular disorders, cancers, neurological age-related diseases, inflammatory disorders also biological activities.
Language: Английский
Citations
1
Foods, Journal Year: 2023, Volume and Issue: 12(19), P. 3610 - 3610
Published: Sept. 28, 2023
Obesity is a complex medical condition mainly caused by eating habits, genetics, lifestyle, and medicine. The present study deals with traditional diets like the Mediterranean diet, Nordic African Heritage Asian DASH, as these are considered to be sustainable for curing obesity. However, bioavailability of phytonutrients consumed in diet may vary, depending on several factors such digestion absorption phytonutrients, interaction other substances, cooking processes, individual differences. Hence, phytochemicals, polyphenols, alkaloids, saponins, terpenoids, etc., have been investigated assess their efficiencies safety prevention treatment These phytochemicals anti-obesity effects, mediated via modulation many pathways, decreased lipogenesis, lipid absorption, accelerated lipolysis, energy intake, expenditure, preadipocyte differentiation proliferation. Owing new food formulations incorporating were introduced that can beneficial reducing prevalence obesity promoting public health.
Language: Английский
Citations
21
Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(33), P. 11880 - 11924
Published: July 15, 2022
Breast cancer (BC) is the most prevalent neoplasm among women. Genetic and environmental factors lead to BC development on this basis, several preventive - screening therapeutic interventions have been developed. Hormones, both in form of endogenous hormonal signaling or contraceptives, play an important role pathogenesis progression. On top these, breast microbiota includes species with immunomodulatory activity enhancing host's response against cells producing proinflammatory cytokines associated development. Identification novel multitargeted agents poly-pharmacological potential a dire need combat advanced metastatic BC. A growing body research has emphasized natural compounds derived from medicinal plants microbial as complementary treatment regimens, including dietary supplements probiotics. In particular, extracts such Artemisia monosperma Delile, Origanum dayi Post, Urtica membranacea Poir. ex Savigny, Krameria lappacea (Dombey) Burdet & B.B. Simpson metabolites extracted microbes Deinococcus radiodurans Streptomycetes strains well probiotics like Bacillus coagulans Lactobacillus brevis MK05 exhibited antitumor effects antiproliferative cytotoxic activity, increase tumors' chemosensitivity, antioxidant modulation molecular pathways. Further, bioactive 3,3'-diindolylmethane, epigallocatechin gallate, genistein, rutin, resveratrol, lycopene, sulforaphane, silibinin, rosmarinic acid, shikonin are special interest for researchers clinicians because these multimodal action act via multiple ways managing regularly available our food fruit diets. Evidence clinical trials suggests that products had major effectiveness conventional decreasing their side effects. We here provide comprehensive review mechanistic underpinnings management. The future perspectives translation findings personalized provided discussed.
Language: Английский
Citations
20
International Journal of Obesity, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Abstract The worldwide health emergency of obesity is closely connected to how dietary fats are metabolized, whereas the process significantly influenced by pancreatic lipase (PL), an enzyme critical for lipid hydrolysis into fatty acids. This narrative review employs a methodological approach utilizing literature searches PubMed data up March 2024. search term criteria encompasses keywords related role, mechanism, challenges, and current future treatments in with overall references 106. paper offers comprehensive explanation role PL, underlining its significance digestive imbalances that contribute extension, impact on development progression. Additionally, it delves dual functionality pancreas, emphasizing metabolism energy utilization which, when dysregulated, promotes obesity. A focal point this investigation efficacy, adverse effects inhibitors, orlistat being highlighted as primary drug delivery. By discussing advanced treatments, including exploration novel anti-obesity medications target specific biological pathways, underscores complexity treatment necessity multifaceted approach. In conclusion, importance understanding enzymes like mechanistic adopting multidisciplinary side drugs explore new emerging therapeutic strategies more effective management.
Language: Английский
Citations
0
Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: March 5, 2025
Language: Английский
Citations
0
Current Topics in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 24(4), P. 343 - 363
Published: Nov. 30, 2023
Background: Cinchonine is one of the Cinchona alkaloids that commercially extracted from Peruvian bark officinalis L. (Family: Rubiaceae). It also obtained in much lower quantities other species Cinchona, such as calisaya, succirubra, and pubescens, some plants, Remijia peruviana. has been historically used an anti-malarial agent. a wide range biological properties, including anti-cancer, anti-obesity, anti-inflammatory, anti-parasitic, antimicrobial, anti-platelet aggregation, anti-osteoclast differentiation. Aim Objective: This review discusses pharmacological activity cinchonine under different experimental conditions, silico, vitro, vivo. covers compound's physicochemical toxicological aspects, pharmacokinetics. Methodology: A comprehensive literature search was conducted on multiple online databases, PubMed, Scopus, Google Scholar. The aim to retrieve review/research papers bibliographic sources. process involved applying exclusion inclusion criteria ensure selection relevant high-quality papers. Results: numerous making it promising compound for various therapeutic applications. induces anticancer by activating caspase-3 PARP-1, triggers endoplasmic reticulum stress response. up-regulates GRP78 promotes phosphorylation PERK ETIF-2α. inhibits osteoclastogenesis, inhibiting TAK1 activation suppressing NFATc1 expression regulating AP-1 NF-κB. Its potential anti-inflammatory effects reduce impact high-fat diets, suitable targeting obesity-related diseases. However, research limited, further studies are needed fully understand its potential. Further investigation safety efficacy clinical Conclusion: Overall, this article explains cinchonine, synthesis,
Language: Английский
Citations
9